AutismKB 2.0

Annotation Details for DAB2IP


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Basic Information Top
Gene Symbol:DAB2IP ( AF9Q34,AIP1,DIP1/2,FLJ39072,KIAA1743 )
Gene Full Name: DAB2 interacting protein
Band: 9q33.2
Quick LinksEntrez ID:153090; OMIM: 609205; Uniprot ID:DAB2P_HUMAN; ENSEMBL ID: ENSG00000136848; HGNC ID: 17294
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm15310755
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane15310755
GO:0030139IDA-endocytic vesicle19948740
GO:0030424ISS-axon-
GO:0030425IEA-dendrite-
GO:0031235IBA-intrinsic component of the cytoplasmic side of the plasma membrane-
GO:0032809ISS-neuronal cell body membrane-
GO:0043025ISS-neuronal cell body-
GO:0044300ISS-cerebellar mossy fiber-
GO:0044301ISS-climbing fiber-
GO:0070062IDA-extracellular exosome23376485
GO:1990032ISS-parallel fiber-
GO:1990597IDA-AIP1-IRE1 complex18281285
GO ID Evidence Qualifier GO_term References
GO:0005096IBA-GTPase activator activity-
GO:0005123IPI-death receptor binding15310755
GO:0005515IPI-protein binding12813029
GO:0017124IDA-SH3 domain binding19033661
GO:0019900IPI-kinase binding17389591
GO:0019901IDA-protein kinase binding18281285
GO:0019901IPI-protein kinase binding20080667
GO:0031434IPI-mitogen-activated protein kinase kinase binding17389591
GO:0031435IPI-mitogen-activated protein kinase kinase kinase binding12813029
GO:0032266IDA-phosphatidylinositol-3-phosphate binding19948740
GO:0032403IDA-protein complex binding19903888
GO:0035591IDA-signaling adaptor activity20080667
GO:0035662IDANOTToll-like receptor 4 binding19948740
GO:0036312IDA-phosphatidylinositol 3-kinase regulatory subunit binding19903888
GO:0042802IPI-identical protein binding12813029
GO:0042803IPI-protein homodimerization activity12813029
GO:0043184IPI-vascular endothelial growth factor receptor 2 binding19033661
GO:0043548IDA-phosphatidylinositol 3-kinase binding19033661
GO:0045296IDA-cadherin binding25468996
GO:0051721IDA-protein phosphatase 2A binding20080667
GO:0070273IDA-phosphatidylinositol-4-phosphate binding19948740
GO:0071889IDA-14-3-3 protein binding17389591
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter15310755
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter20154697
GO:0000165TAS-MAPK cascade-
GO:0000185IDA-activation of MAPKKK activity19903888
GO:0001525IEA-angiogenesis-
GO:0001933IMP-negative regulation of protein phosphorylation20080667
GO:0001933ISS-negative regulation of protein phosphorylation-
GO:0006954IEA-inflammatory response-
GO:0006987TAS-activation of signaling protein activity involved in unfolded protein response22013210
GO:0007049IEA-cell cycle-
GO:0007252ISS-I-kappaB phosphorylation-
GO:0007257IDA-activation of JUN kinase activity12813029
GO:0008285IDA-negative regulation of cell proliferation19903888
GO:0008625IMP-extrinsic apoptotic signaling pathway via death domain receptors19903888
GO:0010596IMP-negative regulation of endothelial cell migration19033661
GO:0010633IMP-negative regulation of epithelial cell migration20080667
GO:0010633TAS-negative regulation of epithelial cell migration20080667
GO:0010719IDA-negative regulation of epithelial to mesenchymal transition20154697
GO:0010719IMP-negative regulation of epithelial to mesenchymal transition20080667
GO:0010976ISS-positive regulation of neuron projection development-
GO:0014067IDA-negative regulation of phosphatidylinositol 3-kinase signaling19903888
GO:0016525IDA-negative regulation of angiogenesis19033661
GO:0021814ISS-cell motility involved in cerebral cortex radial glia guided migration-
GO:0021819ISS-layer formation in cerebral cortex-
GO:0030948IMP-negative regulation of vascular endothelial growth factor receptor signaling pathway19033661
GO:0032088IMP-negative regulation of NF-kappaB transcription factor activity20154697
GO:0034144IDA-negative regulation of toll-like receptor 4 signaling pathway19948740
GO:0034260IMP-negative regulation of GTPase activity20154697
GO:0034260ISS-negative regulation of GTPase activity-
GO:0035148IMP-tube formation19033661
GO:0035414ISS-negative regulation of catenin import into nucleus-
GO:0035924IDA-cellular response to vascular endothelial growth factor stimulus19033661
GO:0035924ISS-cellular response to vascular endothelial growth factor stimulus-
GO:0036324ISS-vascular endothelial growth factor receptor-2 signaling pathway-
GO:0038026IEA-reelin-mediated signaling pathway-
GO:0040008IEA-regulation of growth-
GO:0042059ISS-negative regulation of epidermal growth factor receptor signaling pathway11812785
GO:0043065IDA-positive regulation of apoptotic process17389591
GO:0043087ISS-regulation of GTPase activity-
GO:0043122ISS-regulation of I-kappaB kinase/NF-kappaB signaling-
GO:0043124IDA-negative regulation of I-kappaB kinase/NF-kappaB signaling15310755
GO:0043254IDA-regulation of protein complex assembly19948740
GO:0043407IDA-negative regulation of MAP kinase activity12813029
GO:0043407IMP-negative regulation of MAP kinase activity20154697
GO:0043410IDA-positive regulation of MAPK cascade19903888
GO:0043497IDA-regulation of protein heterodimerization activity18281285
GO:0043507IDA-positive regulation of JUN kinase activity15310755
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043553IDA-negative regulation of phosphatidylinositol 3-kinase activity19903888
GO:0044257IDA-cellular protein catabolic process17389591
GO:0045087IEA-innate immune response-
GO:0045732ISS-positive regulation of protein catabolic process-
GO:0045892IMP-negative regulation of transcription, DNA-templated20080667
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter15310755
GO:0046330IDA-positive regulation of JNK cascade17389591
GO:0046580IBA-negative regulation of Ras protein signal transduction-
GO:0046580IC-negative regulation of Ras protein signal transduction20154697
GO:0048147ISS-negative regulation of fibroblast proliferation-
GO:0048812ISS-neuron projection morphogenesis-
GO:0050680IMP-negative regulation of epithelial cell proliferation20154697
GO:0070059ISS-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress18281285
GO:0070317IDA-negative regulation of G0 to G1 transition19903888
GO:0070373IDA-negative regulation of ERK1 and ERK2 cascade19903888
GO:0071158IDA-positive regulation of cell cycle arrest19903888
GO:0071222IDA-cellular response to lipopolysaccharide19948740
GO:0071347IDA-cellular response to interleukin-119948740
GO:0071356IDA-cellular response to tumor necrosis factor12813029
GO:0071364ISS-cellular response to epidermal growth factor stimulus11812785
GO:0071901IDA-negative regulation of protein serine/threonine kinase activity19903888
GO:0071901IMP-negative regulation of protein serine/threonine kinase activity20154697
GO:0071902IDA-positive regulation of protein serine/threonine kinase activity19903888
GO:0071902IMP-positive regulation of protein serine/threonine kinase activity20080667
GO:0072577TAS-endothelial cell apoptotic process19903888
GO:0090090IMP-negative regulation of canonical Wnt signaling pathway20080667
GO:0090129ISS-positive regulation of synapse maturation-
GO:1900006ISS-positive regulation of dendrite development-
GO:1900744ISS-regulation of p38MAPK cascade-
GO:1900747ISS-negative regulation of vascular endothelial growth factor signaling pathway-
GO:1901800IMP-positive regulation of proteasomal protein catabolic process20080667
GO:1903363IDA-negative regulation of cellular protein catabolic process19903888
GO:1903896TAS-positive regulation of IRE1-mediated unfolded protein response22013210
GO:2001224ISS-positive regulation of neuron migration-
GO:2001235IDA-positive regulation of apoptotic signaling pathway19903888
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DAB2IPDAB212747811812785 Affinity Capture-Western; Reconstituted Complex
DAB2IPDAB210797111812785 Affinity Capture-Western; Reconstituted Complex
DAB2IPTP5312747820308539 Affinity Capture-Western
DAB2IPTP5311301020308539 Affinity Capture-Western
DAB2IPTP7312747820308539 Affinity Capture-Western
DAB2IPTP7311301420308539 Affinity Capture-Western
DAB2IPTP6312747820308539 Affinity Capture-Western
DAB2IPTP6311418120308539 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1916851
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-2449'