AutismKB 2.0

Annotation Details for CYBA


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Basic Information Top
Gene Symbol:CYBA ( p22-PHOX )
Gene Full Name: cytochrome b-245, alpha polypeptide
Band: 16q24.2
Quick LinksEntrez ID:1535; OMIM: 608508; Uniprot ID:CY24A_HUMAN; ENSEMBL ID: ENSG00000051523; HGNC ID: 2577
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001725IEA-stress fiber-
GO:0005634IEA-nucleus-
GO:0005739IEA-mitochondrion-
GO:0005768IEA-endosome-
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005794IEA-Golgi apparatus-
GO:0005886TAS-plasma membrane-
GO:0005925IEA-focal adhesion-
GO:0016020IDA-membrane19946888
GO:0016324IEA-apical plasma membrane-
GO:0030141TAS-secretory granule12005167
GO:0030425IEA-dendrite-
GO:0030670TAS-phagocytic vesicle membrane-
GO:0035579TAS-specific granule membrane-
GO:0043020IDA-NADPH oxidase complex3305576
GO:0043020IDAcolocalizes_withNADPH oxidase complex22423966
GO:0043020IMP-NADPH oxidase complex1763037
GO:0043025IEA-neuronal cell body-
GO:0070821TAS-tertiary granule membrane-
GO:0097038IEA-perinuclear endoplasmic reticulum-
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding3305576
GO:0009055IDA-electron carrier activity12042318
GO:0009055TAS-electron carrier activity2243141
GO:0016175IMPcontributes_tosuperoxide-generating NADPH oxidase activity1763037
GO:0016175TAS-superoxide-generating NADPH oxidase activity-
GO:0017124IPI-SH3 domain binding7938008
GO:0020037IEA-heme binding-
GO:0046872IEA-metal ion binding-
GO:0046982IPI-protein heterodimerization activity12042318
GO ID Evidence Qualifier GO_term References
GO:0001666IEA-response to hypoxia-
GO:0001938IEA-positive regulation of endothelial cell proliferation-
GO:0002479TAS-antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-
GO:0003106IEA-negative regulation of glomerular filtration by angiotensin-
GO:0006801IMP-superoxide metabolic process1763037
GO:0006954IMP-inflammatory response2243141
GO:0014823IEA-response to activity-
GO:0014895ISS-smooth muscle hypertrophy-
GO:0017004IDA-cytochrome complex assembly7938008
GO:0030307IEA-positive regulation of cell growth-
GO:0031667IEA-response to nutrient levels-
GO:0032755IDA-positive regulation of interleukin-6 production22423966
GO:0032760IDA-positive regulation of tumor necrosis factor production22423966
GO:0032930IEA-positive regulation of superoxide anion generation-
GO:0033864IEA-positive regulation of NAD(P)H oxidase activity-
GO:0034137IDA-positive regulation of toll-like receptor 2 signaling pathway22423966
GO:0034599TAS-cellular response to oxidative stress-
GO:0042493IEA-response to drug-
GO:0042554IMP-superoxide anion generation2243141
GO:0043312TAS-neutrophil degranulation-
GO:0045087IMP-innate immune response2243141
GO:0045454TAS-cell redox homeostasis-
GO:0045730IMP-respiratory burst2243141
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0050665ISS-hydrogen peroxide biosynthetic process-
GO:0050766IDA-positive regulation of phagocytosis22423966
GO:0051279IEA-regulation of release of sequestered calcium ion into cytosol-
GO:0055114IMP-oxidation-reduction process1763037
GO:0070257IEA-positive regulation of mucus secretion-
GO:0070555IEA-response to interleukin-1-
GO:0071260IEA-cellular response to mechanical stimulus-
GO:0071333IEA-cellular response to glucose stimulus-
GO:0071356IEA-cellular response to tumor necrosis factor-
GO:0071407IEA-cellular response to organic cyclic compound-
GO:0071480IEA-cellular response to gamma radiation-
GO:1900426IDA-positive regulation of defense response to bacterium22423966
GO:1903428IDA-positive regulation of reactive oxygen species biosynthetic process22423966
GO:1904044IEA-response to aldosterone-
GO:1904385IEA-cellular response to angiotensin-
GO:1904845IEA-cellular response to L-glutamine-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
NCF1CYBA5757247938008 Reconstituted Complex
NCF1CYBA1079157938008 Reconstituted Complex
NCF2CYBA11076811733522 11917128 Protein-peptide; Reconstituted Complex
NCF2CYBA10791511733522 11917128 Protein-peptide; Reconstituted Complex
UBCCYBA11316417200123 Affinity Capture-Western
UBCCYBA10791517200123 Affinity Capture-Western
VHLCYBA11326917200123 Affinity Capture-Western
VHLCYBA10791517200123 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1316658
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040426-1526'