AutismKB 2.0

Annotation Details for ADRB2


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Basic Information Top
Gene Symbol:ADRB2 ( ADRB2R,ADRBR,B2AR,BAR,BETA2AR )
Gene Full Name: adrenergic, beta-2-, receptor, surface
Band: 5q32
Quick LinksEntrez ID:154; OMIM: 109690; Uniprot ID:ADRB2_HUMAN; ENSEMBL ID: ENSG00000169252; HGNC ID: 286
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005764TAS-lysosome9507004
GO:0005768TAS-endosome10734107
GO:0005769IEA-early endosome-
GO:0005886IDA-plasma membrane9235896
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane12297500
GO:0010008TAS-endosome membrane-
GO:0016324IEA-apical plasma membrane-
GO:0030665TAS-clathrin-coated vesicle membrane-
GO:0043235IDA-receptor complex15123695
GO ID Evidence Qualifier GO_term References
GO:0004941IDA-beta2-adrenergic receptor activity15123695
GO:0005515IPI-protein binding9560162
GO:0008179IEA-adenylate cyclase binding-
GO:0015459IDA-potassium channel regulator activity12297500
GO:0042803IDA-protein homodimerization activity15123695
GO:0051379IBA-epinephrine binding-
GO:0051380IDA-norepinephrine binding15123695
GO ID Evidence Qualifier GO_term References
GO:0002024IEA-diet induced thermogenesis-
GO:0002025IBA-norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure-
GO:0002028IEA-regulation of sodium ion transport-
GO:0002032IDA-desensitization of G-protein coupled receptor protein signaling pathway by arrestin15123695
GO:0006898IDA-receptor-mediated endocytosis15123695
GO:0007166TAS-cell surface receptor signaling pathway1371121
GO:0007171TAS-activation of transmembrane receptor protein tyrosine kinase activity10734107
GO:0007188TAS-adenylate cyclase-modulating G-protein coupled receptor signaling pathway2823249
GO:0007190IDA-activation of adenylate cyclase activity15123695
GO:0007267IBA-cell-cell signaling-
GO:0008333TAS-endosome to lysosome transport9507004
GO:0009409IEA-response to cold-
GO:0016579TAS-protein deubiquitination-
GO:0030501IEA-positive regulation of bone mineralization-
GO:0031398IMP-positive regulation of protein ubiquitination19372219
GO:0031649IEA-heat generation-
GO:0040015IEA-negative regulation of multicellular organism growth-
GO:0043410IDA-positive regulation of MAPK cascade15123695
GO:0045453IEA-bone resorption-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0045986IBA-negative regulation of smooth muscle contraction-
GO:0050873IEA-brown fat cell differentiation-
GO:0061024TAS-membrane organization-
GO:0071875IDA-adrenergic receptor signaling pathway19710023
GO:0071880IBA-adenylate cyclase-activating adrenergic receptor signaling pathway-
GO:1901098IDA-positive regulation of autophagosome maturation23708524
GO:1904504IDA-positive regulation of lipophagy23708524
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF2B1ADRB21082869235896 Reconstituted Complex
EIF2B1ADRB21066639235896 Reconstituted Complex
SLC9A3R1ADRB21147699560162 9671706 11882663 Co-crystal Structure; Reconstituted Complex
SLC9A3R1ADRB21066639560162 9671706 11882663 Co-crystal Structure; Reconstituted Complex
SLC9A3R2ADRB21147549671706 Reconstituted Complex
SLC9A3R2ADRB21066639671706 Reconstituted Complex
GRK6ADRB21091289819198 Biochemical Activity
GRK6ADRB21066639819198 Biochemical Activity
GRB2ADRB21091429830057 Affinity Capture-Western; Reconstituted Complex
GRB2ADRB21066639830057 Affinity Capture-Western; Reconstituted Complex
AKAP12ADRB21149589880537 11309381 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
AKAP12ADRB21066639880537 11309381 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
PPP3CAADRB21115229880537 Co-fractionation
PPP3CAADRB21066639880537 Co-fractionation
SRCADRB211259211013230 Affinity Capture-Western
SRCADRB210666311013230 Affinity Capture-Western
OPRD1ADRB211103011278447 Affinity Capture-Western; FRET
OPRD1ADRB210666311278447 Affinity Capture-Western; FRET
ADRB2ADRB210666311278447 FRET
ADRBK1ADRB210666311309381 Affinity Capture-Western
ADRBK1ADRB210666511309381 Affinity Capture-Western
KCNJ3ADRB210666312297500 Affinity Capture-Western
KCNJ3ADRB210996212297500 Affinity Capture-Western
KCNJ5ADRB210996412297500 Affinity Capture-Western
KCNJ5ADRB210666312297500 Affinity Capture-Western
UBCADRB211316415331590 18544533 Affinity Capture-Western
UBCADRB210666315331590 18544533 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ADRB2ADRB2_G16R, ADRB2_Q27G Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:87938
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070410-32'