AutismKB 2.0

Annotation Details for CYP1A2


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Basic Information Top
Gene Symbol:CYP1A2 ( CP12,P3-450,P450(PA) )
Gene Full Name: cytochrome P450, family 1, subfamily A, polypeptide 2
Band: 15q24.1
Quick LinksEntrez ID:1544; OMIM: 124060; Uniprot ID:CP1A2_HUMAN; ENSEMBL ID: ENSG00000140505; HGNC ID: 2596
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0031090IEA-organelle membrane-
GO:0043231IDA-intracellular membrane-bounded organelle2813353
GO ID Evidence Qualifier GO_term References
GO:0004497IDA-monooxygenase activity15327587
GO:0004497TAS-monooxygenase activity-
GO:0005506IEA-iron ion binding-
GO:0009055TAS-electron carrier activity2813353
GO:0016491IDA-oxidoreductase activity16401082
GO:0016712IMP-oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen2813353
GO:0019825TAS-oxygen binding-
GO:0019899IPI-enzyme binding15680923
GO:0020037IDA-heme binding17311915
GO:0032451IDA-demethylase activity2813353
GO:0034875IDA-caffeine oxidase activity18619574
GO:0070330IEA-aromatase activity-
GO ID Evidence Qualifier GO_term References
GO:0006706IMP-steroid catabolic process18356043
GO:0006778IEA-porphyrin-containing compound metabolic process-
GO:0006805TAS-xenobiotic metabolic process-
GO:0009403IDA-toxin biosynthetic process11511187
GO:0009791IEA-post-embryonic development-
GO:0009820IDA-alkaloid metabolic process11511187
GO:0010468IEA-regulation of gene expression-
GO:0016098IDA-monoterpenoid metabolic process16401082
GO:0017144IDA-drug metabolic process15327587
GO:0018894IEA-dibenzo-p-dioxin metabolic process-
GO:0019373TAS-epoxygenase P450 pathway-
GO:0030324IEA-lung development-
GO:0032259TAS-methylation-
GO:0032355IEA-response to estradiol-
GO:0032496IEA-response to lipopolysaccharide-
GO:0032787IDA-monocarboxylic acid metabolic process19651758
GO:0035902IEA-response to immobilization stress-
GO:0042737IMP-drug catabolic process18356043
GO:0042738IDA-exogenous drug catabolic process18619574
GO:0045333IEA-cellular respiration-
GO:0046483IDA-heterocycle metabolic process15327587
GO:0050665IEA-hydrogen peroxide biosynthetic process-
GO:0055114IDA-oxidation-reduction process16401082
GO:0070989IDA-oxidative demethylation18619574
GO:0071276IEA-cellular response to cadmium ion-
GO:0071280IEA-cellular response to copper ion-
GO:0071615IDA-oxidative deethylation19029318
GO:0097267TAS-omega-hydroxylase P450 pathway-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PORCYP1A21079249398194 Reconstituted Complex
PORCYP1A21114439398194 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
CYP1A2rs35694136, rs762551 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
CYP1A2CYP1A2*1C, CYP1A2*1F, rs762551 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:88589
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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