AutismKB 2.0

Annotation Details for ADRBK1


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Basic Information Top
Gene Symbol:ADRBK1 ( BARK1,BETA-ARK1,FLJ16718,GRK2 )
Gene Full Name: adrenergic, beta, receptor kinase 1
Band: 11q13.1
Quick LinksEntrez ID:156; OMIM: 109635; Uniprot ID:ARBK1_HUMAN; ENSEMBL ID: ENSG00000173020; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm17986524
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0005929TAS-cilium-
GO:0016020IDA-membrane19946888
GO:0016020ISS-membrane-
GO ID Evidence Qualifier GO_term References
GO:0004672ISS-protein kinase activity-
GO:0004703ISS-G-protein coupled receptor kinase activity-
GO:0005515IPI-protein binding17006543
GO:0005524IEA-ATP binding-
GO:0031694ISS-alpha-2A adrenergic receptor binding-
GO:0031755IDA-Edg-2 lysophosphatidic acid receptor binding19306925
GO:0047696TAS-beta-adrenergic receptor kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0002029ISS-desensitization of G-protein coupled receptor protein signaling pathway-
GO:0003108IMP-negative regulation of the force of heart contraction by chemical signal15051637
GO:0007213ISS-G-protein coupled acetylcholine receptor signaling pathway-
GO:0007217IDA-tachykinin receptor signaling pathway17986524
GO:0007507IEA-heart development-
GO:0018105ISS-peptidyl-serine phosphorylation-
GO:0018107IEA-peptidyl-threonine phosphorylation-
GO:0019079IMP-viral genome replication23029581
GO:0031623IDA-receptor internalization20074556
GO:0033605ISS-positive regulation of catecholamine secretion-
GO:0045988IMP-negative regulation of striated muscle contraction15051637
GO:0046718IMP-viral entry into host cell23029581
GO:0060048IMP-cardiac muscle contraction15051637
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ADRBK1ADRB210666311309381 Affinity Capture-Western
ADRBK1ADRB210666511309381 Affinity Capture-Western
AGTR1ADRBK11066919211925 Affinity Capture-Western
AGTR1ADRBK11066659211925 Affinity Capture-Western
EDNRBADRBK11082329211925 Affinity Capture-Western
EDNRBADRBK11066659211925 Affinity Capture-Western
GIT1ADRBK11066659826657 10896954 Affinity Capture-Western
GIT1ADRBK11187899826657 10896954 Affinity Capture-Western
CAV1ADRBK110666510085129 Reconstituted Complex
CAV1ADRBK110730510085129 Reconstituted Complex
FSHRADRBK110877010379886 Biochemical Activity
FSHRADRBK110666510379886 Biochemical Activity
RHOADRBK110666510722682 Reconstituted Complex
RHOADRBK111194210722682 Reconstituted Complex
CCR4ADRBK110763810754297 Affinity Capture-Western
CCR4ADRBK110666510754297 Affinity Capture-Western
PDCLADRBK111111610884381 Biochemical Activity
PDCLADRBK110666510884381 Biochemical Activity
PDCADRBK111115910884381 Biochemical Activity
PDCADRBK110666510884381 Biochemical Activity
GIT2ADRBK110666510896954 Affinity Capture-Western
GIT2ADRBK111515410896954 Affinity Capture-Western
PDGFRBADRBK110666512381737 Affinity Capture-Western
PDGFRBADRBK111118512381737 Affinity Capture-Western
SRCADRBK110666512624098 Affinity Capture-Western
SRCADRBK111259212624098 Affinity Capture-Western
PDE6GADRBK110666512624098 Affinity Capture-Western; Reconstituted Complex
PDE6GADRBK111117412624098 Affinity Capture-Western; Reconstituted Complex
PRKCBADRBK110666512679936 Affinity Capture-Western; Reconstituted Complex
PRKCBADRBK111156512679936 Affinity Capture-Western; Reconstituted Complex
GNA15ADRBK110903112885252 Affinity Capture-Western; Reconstituted Complex
GNA15ADRBK110666512885252 Affinity Capture-Western; Reconstituted Complex
GNAQADRBK110666512885252 Affinity Capture-Western; Reconstituted Complex
GNAQADRBK110903812885252 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
ADRBK1rs4930418, rs5723861 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:87940
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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