AutismKB 2.0

Annotation Details for DAB2


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Basic Information Top
Gene Symbol:DAB2 ( DOC-2,DOC2,FLJ26626 )
Gene Full Name: disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
Band: 5p13.1
Quick LinksEntrez ID:1601; OMIM: 601236; Uniprot ID:DAB2_HUMAN; ENSEMBL ID: ENSG00000153071; HGNC ID: 2662
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001650IDA-fibrillar center-
GO:0005730IDA-nucleolus-
GO:0005765TAS-lysosomal membrane-
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane-
GO:0005886TAS-plasma membrane-
GO:0005905IDA-clathrin-coated pit12857860
GO:0005925IDA-focal adhesion21423176
GO:0030136IDA-clathrin-coated vesicle19581412
GO:0030665IEA-clathrin-coated vesicle membrane-
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0070022IDAcolocalizes_withtransforming growth factor beta receptor complex11387212
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0005515IPI-protein binding11387212
GO:0008022IPI-protein C-terminus binding15837803
GO:0035615IMP-clathrin adaptor activity16984970
GO:0038024IMP-cargo receptor activity16984970
GO:0046332IDA-SMAD binding11387212
GO ID Evidence Qualifier GO_term References
GO:0001934IMP-positive regulation of protein phosphorylation12805222
GO:0006898IEA-receptor-mediated endocytosis-
GO:0006915IEA-apoptotic process-
GO:0007229IMPNOTintegrin-mediated signaling pathway19581412
GO:0007275IEA-multicellular organism development-
GO:0008283TAS-cell proliferation9620555
GO:0010718IDA-positive regulation of epithelial to mesenchymal transition15734730
GO:0010862IDA-positive regulation of pathway-restricted SMAD protein phosphorylation11387212
GO:0015031IEA-protein transport-
GO:0016055IEA-Wnt signaling pathway-
GO:0030335IMP-positive regulation of cell migration19581412
GO:0030511IDA-positive regulation of transforming growth factor beta receptor signaling pathway11387212
GO:0032091IMP-negative regulation of protein binding12805222
GO:0032436IMP-positive regulation of proteasomal ubiquitin-dependent protein catabolic process12805222
GO:0035026IMP-leading edge cell differentiation19581412
GO:0043066IDA-negative regulation of apoptotic process15734730
GO:0045807IMP-positive regulation of endocytosis19581412
GO:0045892IMP-negative regulation of transcription, DNA-templated12805222
GO:0045893IMP-positive regulation of transcription, DNA-templated12805222
GO:0060391IDA-positive regulation of SMAD protein import into nucleus11387212
GO:0060766IMP-negative regulation of androgen receptor signaling pathway16267015
GO:0061024TAS-membrane organization-
GO:0090090IMP-negative regulation of canonical Wnt signaling pathway12805222
GO:0090090ISS-negative regulation of canonical Wnt signaling pathway-
GO:1903077IMP-negative regulation of protein localization to plasma membrane19581412
GO:2000096IMP-positive regulation of Wnt signaling pathway, planar cell polarity pathway12805222
GO:2000370IMP-positive regulation of clathrin-dependent endocytosis16984970
GO:2000643IMP-positive regulation of early endosome to late endosome transport21995445
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DAB2AP2A210667011247302 Affinity Capture-Western
DAB2AP2A210797111247302 Affinity Capture-Western
DAB2APLP110797111247302 Reconstituted Complex
DAB2APLP110683011247302 Reconstituted Complex
DAB2APLP210797111247302 Reconstituted Complex
DAB2APLP210683111247302 Reconstituted Complex
DAB2APP10684811247302 Reconstituted Complex
DAB2APP10797111247302 Reconstituted Complex
DAB2CDK110797112881709 Affinity Capture-Western; Biochemical Activity
DAB2CDK110742012881709 Affinity Capture-Western; Biochemical Activity
DAB2CSK10783212473651 Affinity Capture-Western; Reconstituted Complex
DAB2CSK10797112473651 Affinity Capture-Western; Reconstituted Complex
LRP2DAB211021610769163 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LRP2DAB210797110769163 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
INPP5DDAB210984711247302 Reconstituted Complex
INPP5DDAB210797111247302 Reconstituted Complex
LDLRDAB211014111247302 Reconstituted Complex
LDLRDAB210797111247302 Reconstituted Complex
LRP1DAB211021511247302 Reconstituted Complex
LRP1DAB210797111247302 Reconstituted Complex
TGFBR1DAB210797111387212 Affinity Capture-Western
TGFBR1DAB211290411387212 Affinity Capture-Western
TGFBR2DAB211290611387212 Affinity Capture-Western
TGFBR2DAB210797111387212 Affinity Capture-Western
SMAD2DAB210797111387212 Affinity Capture-Western; Reconstituted Complex
SMAD2DAB211026211387212 Affinity Capture-Western; Reconstituted Complex
SMAD3DAB211026311387212 Affinity Capture-Western; Reconstituted Complex
SMAD3DAB210797111387212 Affinity Capture-Western; Reconstituted Complex
DAB2IPDAB212747811812785 Affinity Capture-Western; Reconstituted Complex
DAB2IPDAB210797111812785 Affinity Capture-Western; Reconstituted Complex
MYO6DAB211073011906161 11967127 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
MYO6DAB210797111906161 11967127 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
SRCDAB211259212473651 Affinity Capture-Western; Reconstituted Complex
SRCDAB210797112473651 Affinity Capture-Western; Reconstituted Complex
FGRDAB210855912473651 Reconstituted Complex
FGRDAB210797112473651 Reconstituted Complex
DVL2DAB210797112805222 Affinity Capture-Western; Reconstituted Complex
DVL2DAB210818912805222 Affinity Capture-Western; Reconstituted Complex
DVL3DAB210797112805222 Affinity Capture-Western; Reconstituted Complex
DVL3DAB210819012805222 Affinity Capture-Western; Reconstituted Complex
DVL1DAB210818812805222 Reconstituted Complex
DVL1DAB210797112805222 Reconstituted Complex
AXIN1DAB211390912805222 Reconstituted Complex
AXIN1DAB210797112805222 Reconstituted Complex
PIN1DAB211131712881709 Affinity Capture-Western; Reconstituted Complex
PIN1DAB210797112881709 Affinity Capture-Western; Reconstituted Complex
GRB2DAB210797120936779 Two-hybrid
GRB2DAB210914220936779 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109175
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040303-1'