AutismKB 2.0

Annotation Details for DACH1


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Basic Information Top
Gene Symbol:DACH1 ( DACH,FLJ10138 )
Gene Full Name: dachshund homolog 1 (Drosophila)
Band: 13q21.33
Quick LinksEntrez ID:1602; OMIM: 603803; Uniprot ID:DACH1_HUMAN; ENSEMBL ID: ENSG00000165659; HGNC ID: 2663
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IBA-nucleus-
GO:0005667IBA-transcription factor complex-
GO:0005737IEA-cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0001075IBA-transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly-
GO:0001078IDA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding20956529
GO:0003677IEA-DNA binding-
GO:0005515IPI-protein binding14525983
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001967IEA-suckling behavior-
GO:0007275IBA-multicellular organism development-
GO:0007585IEA-respiratory gaseous exchange-
GO:0008283IEA-cell proliferation-
GO:0010944IMP-negative regulation of transcription by competitive promoter binding20956529
GO:0030336IDA-negative regulation of cell migration20956529
GO:0033262IEA-regulation of nuclear cell cycle DNA replication-
GO:0045892IMP-negative regulation of transcription, DNA-templated21750150
GO:0046545IEA-development of primary female sexual characteristics-
GO:0048147IEA-negative regulation of fibroblast proliferation-
GO:0051123IEA-RNA polymerase II transcriptional preinitiation complex assembly-
GO:0060244IEA-negative regulation of cell proliferation involved in contact inhibition-
GO:2000279IDA-negative regulation of DNA biosynthetic process16980615
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DACH1CREB110777516980615 Affinity Capture-Western
DACH1CREB110797216980615 Affinity Capture-Western
UBE2IDACH111317711025202 16189514 Reconstituted Complex; Two-hybrid
UBE2IDACH110797211025202 16189514 Reconstituted Complex; Two-hybrid
NAGKDACH112072816189514 Two-hybrid
NAGKDACH110797216189514 Two-hybrid
JUNDACH110992816980615 17182846 Affinity Capture-Western; Two-hybrid
JUNDACH110797216980615 17182846 Affinity Capture-Western; Two-hybrid
HDAC1DACH110797217182846 Affinity Capture-Western
HDAC1DACH110931517182846 Affinity Capture-Western
HDAC3DACH110797217182846 Affinity Capture-Western
HDAC3DACH111436817182846 Affinity Capture-Western
NCOR1DACH111497317182846 Affinity Capture-Western
NCOR1DACH110797217182846 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1277991
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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