AutismKB 2.0

Annotation Details for DAG1


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Basic Information Top
Gene Symbol:DAG1 ( 156DAG,A3a,AGRNR,DAG )
Gene Full Name: dystroglycan 1 (dystrophin-associated glycoprotein 1)
Band: 3p21.31
Quick LinksEntrez ID:1605; OMIM: 128239; Uniprot ID:DAG1_HUMAN; ENSEMBL ID: ENSG00000173402; HGNC ID: 2666
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005604IDA-basement membrane19348877
GO:0005615IDA-extracellular space16502470
GO:0005654IDA-nucleoplasm18764929
GO:0005737IDA-cytoplasm18764929
GO:0005788TAS-endoplasmic reticulum lumen-
GO:0005796TAS-Golgi lumen-
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0005886IDA-plasma membrane8017170
GO:0005886TAS-plasma membrane-
GO:0005913IEA-cell-cell adherens junction-
GO:0005925IDA-focal adhesion21423176
GO:0005925IDAcolocalizes_withfocal adhesion18341635
GO:0009897IEA-external side of plasma membrane-
GO:0016010IDA-dystrophin-associated glycoprotein complex17993586
GO:0016011IEA-dystroglycan complex-
GO:0016021IDA-integral component of membrane17628813
GO:0016323IEA-basolateral plasma membrane-
GO:0030027IDA-lamellipodium18341635
GO:0030175IDA-filopodium18341635
GO:0033268IEA-node of Ranvier-
GO:0042383IEA-sarcolemma-
GO:0043034IEA-costamere-
GO:0044853IEA-plasma membrane raft-
GO:0045211IEA-postsynaptic membrane-
GO:0070062IDA-extracellular exosome19199708
GO:0070938IDA-contractile ring18341635
GO ID Evidence Qualifier GO_term References
GO:0001618IEA-virus receptor activity-
GO:0002162IEA-dystroglycan binding-
GO:0003779IDA-actin binding18341635
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding9417121
GO:0008307IMP-structural constituent of muscle18691338
GO:0015631IDA-tubulin binding18341635
GO:0017166IPI-vinculin binding18341635
GO:0042169IDA-SH2 domain binding11724572
GO:0043237ISS-laminin-1 binding-
GO:0051393IDA-alpha-actinin binding18341635
GO ID Evidence Qualifier GO_term References
GO:0001954IEA-positive regulation of cell-matrix adhesion-
GO:0002011IEA-morphogenesis of an epithelial sheet-
GO:0006493TAS-protein O-linked glycosylation-
GO:0006509IDA-membrane protein ectodomain proteolysis19946898
GO:0006607IDA-NLS-bearing protein import into nucleus20512930
GO:0007016IMP-cytoskeletal anchoring at plasma membrane18341635
GO:0007568IEA-aging-
GO:0010470IMP-regulation of gastrulation23940118
GO:0010717IMP-regulation of epithelial to mesenchymal transition23940118
GO:0014894IEA-response to denervation involved in regulation of muscle adaptation-
GO:0016340IEA-calcium-dependent cell-matrix adhesion-
GO:0016476ISS-regulation of embryonic cell shape-
GO:0019048IDA-modulation by virus of host morphology or physiology16254364
GO:0021682IEA-nerve maturation-
GO:0022011IEA-myelination in peripheral nervous system-
GO:0030198TAS-extracellular matrix organization-
GO:0030336IMP-negative regulation of cell migration19587235
GO:0031103IEA-axon regeneration-
GO:0031643IEA-positive regulation of myelination-
GO:0034453IMP-microtubule anchoring18341635
GO:0043403IEA-skeletal muscle tissue regeneration-
GO:0043409IMP-negative regulation of MAPK cascade19587235
GO:0043434IEA-response to peptide hormone-
GO:0045860IEA-positive regulation of protein kinase activity-
GO:0046718IEA-viral entry into host cell-
GO:0048714IEA-positive regulation of oligodendrocyte differentiation-
GO:0051898IMP-negative regulation of protein kinase B signaling19587235
GO:0060441IEA-epithelial tube branching involved in lung morphogenesis-
GO:0060445IEA-branching involved in salivary gland morphogenesis-
GO:0071260IEA-cellular response to mechanical stimulus-
GO:0071397IEA-cellular response to cholesterol-
GO:0071679IEA-commissural neuron axon guidance-
GO:0071711IEA-basement membrane organization-
GO:1904261IMP-positive regulation of basement membrane assembly involved in embryonic body morphogenesis23940118
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DAG1CAV110730511724572 Reconstituted Complex
DAG1CAV110797511724572 Reconstituted Complex
DAG1CAV310797510988290 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
DAG1CAV310730710988290 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
DAG1CSK10783211724572 Affinity Capture-Western; Reconstituted Complex
DAG1CSK10797511724572 Affinity Capture-Western; Reconstituted Complex
RAPSNDAG11118487619516 Co-localization
RAPSNDAG11079757619516 Co-localization
SGCADAG11123407744812 Affinity Capture-Western
SGCADAG11079757744812 Affinity Capture-Western
GRB2DAG11079757744812 Affinity Capture-Western; Reconstituted Complex
GRB2DAG11091427744812 Affinity Capture-Western; Reconstituted Complex
LAMA2DAG11101027925941 Reconstituted Complex
LAMA2DAG11079757925941 Reconstituted Complex
AGRNDAG11320008205617 Far Western
AGRNDAG11079758205617 Far Western
LAMA5DAG111010510207021 Reconstituted Complex
LAMA5DAG110797510207021 Reconstituted Complex
UTRNDAG110797510769203 Reconstituted Complex
UTRNDAG111324510769203 Reconstituted Complex
DMDDAG110809610932245 Co-crystal Structure
DMDDAG110797510932245 Co-crystal Structure
PRXDAG112173911430802 Affinity Capture-Western
PRXDAG110797511430802 Affinity Capture-Western
DRP2DAG110797511430802 Two-hybrid
DRP2DAG110815511430802 Two-hybrid
SRCDAG111259211724572 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SRCDAG110797511724572 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
FYNDAG110797511724572 Affinity Capture-Western; Reconstituted Complex
FYNDAG110881011724572 Affinity Capture-Western; Reconstituted Complex
NCK1DAG111077011724572 Affinity Capture-Western; Reconstituted Complex
NCK1DAG110797511724572 Affinity Capture-Western; Reconstituted Complex
SHC1DAG110797511724572 Affinity Capture-Western; Reconstituted Complex
SHC1DAG111236111724572 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:101864
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-021223-1'