AutismKB 2.0

Annotation Details for DAPK1


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Basic Information Top
Gene Symbol:DAPK1 ( DAPK,DKFZp781I035 )
Gene Full Name: death-associated protein kinase 1
Band: 9q21.33
Quick LinksEntrez ID:1612; OMIM: 600831; Uniprot ID:DAPK1_HUMAN; ENSEMBL ID: ENSG00000196730; HGNC ID: 2674
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm12730201
GO:0005886IDA-plasma membrane12730201
GO:0015629IDA-actin cytoskeleton10629061
GO ID Evidence Qualifier GO_term References
GO:0004672IDA-protein kinase activity7828849
GO:0004674TAS-protein serine/threonine kinase activity16756490
GO:0004683IDA-calmodulin-dependent protein kinase activity10629061
GO:0005515IPI-protein binding15616583
GO:0005516IDA-calmodulin binding10629061
GO:0005524IDA-ATP binding10629061
GO:0005525IEA-GTP binding-
GO:0017075IPI-syntaxin-1 binding12730201
GO:0042802IPI-identical protein binding19180116
GO ID Evidence Qualifier GO_term References
GO:0006468IDA-protein phosphorylation10629061
GO:0006468TAS-protein phosphorylation16756490
GO:0006915IGI-apoptotic process7828849
GO:0006915IMP-apoptotic process10629061
GO:0008625IEA-extrinsic apoptotic signaling pathway via death domain receptors-
GO:0010506TAS-regulation of autophagy16756490
GO:0010508IMP-positive regulation of autophagy22095288
GO:0017148IDA-negative regulation of translation18995835
GO:0035556IDA-intracellular signal transduction10629061
GO:0042981TAS-regulation of apoptotic process16756490
GO:0043280IDA-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process16132846
GO:0046777IDA-protein autophosphorylation10629061
GO:0046777TAS-protein autophosphorylation16756490
GO:0071346IDA-cellular response to interferon-gamma18995835
GO:0071447IMP-cellular response to hydroperoxide22095288
GO:0097190IMP-apoptotic signaling pathway7828849
GO:1902042IEA-negative regulation of extrinsic apoptotic signaling pathway via death domain receptors-
GO:2000310ISS-regulation of NMDA receptor activity-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DAPK1KRIT110798212911633 Affinity Capture-Western
DAPK1KRIT110733012911633 Affinity Capture-Western
MIB1DAPK112159312351649 Affinity Capture-Western
MIB1DAPK110798212351649 Affinity Capture-Western
UBCDAPK111316412351649 Affinity Capture-Western
UBCDAPK110798212351649 Affinity Capture-Western
YWHAQDAPK111616812911633 Affinity Capture-Western
YWHAQDAPK110798212911633 Affinity Capture-Western
TNFRSF1ADAPK111298612911633 Affinity Capture-Western
TNFRSF1ADAPK110798212911633 Affinity Capture-Western
FADDDAPK111430212911633 Affinity Capture-Western
FADDDAPK110798212911633 Affinity Capture-Western
CCNDBP1DAPK110798217324930 Affinity Capture-Western
CCNDBP1DAPK111711717324930 Affinity Capture-Western
HSP90AA1DAPK110955217324930 Affinity Capture-Western
HSP90AA1DAPK110798217324930 Affinity Capture-Western
ST13DAPK110798217324930 Affinity Capture-Western
ST13DAPK111264417324930 Affinity Capture-Western
TP53DAPK111301017339337 Affinity Capture-Western
TP53DAPK110798217339337 Affinity Capture-Western
IKBKGDAPK111408920098747 Reconstituted Complex
IKBKGDAPK110798220098747 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
DAPK1rs12378187, rs4877365, rs4878104 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1916885
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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