Gene Symbol:	ACE ( ACE1,CD143,DCP,DCP1,MGC26566,MVCD3 )
Gene Full Name:	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Band:	17q23.3
Quick Links	Entrez ID:1636; OMIM: 106180; Uniprot ID:ACE_HUMAN; ENSEMBL ID: ENSG00000159640; HGNC ID: 2707
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005576	TAS	-	extracellular region	-
GO:0005615	IDA	-	extracellular space	1668266
GO:0005764	IDA	-	lysosome	11076943
GO:0005768	IDA	-	endosome	17077303
GO:0005886	IDA	-	plasma membrane	17077303
GO:0005886	TAS	-	plasma membrane	-
GO:0009897	IDA	-	external side of plasma membrane	9449382
GO:0016021	IEA	-	integral component of membrane	-
GO:0070062	IDA	-	extracellular exosome	15326289

GO ID	Evidence	Qualifier	GO_term	References
GO:0004175	IDA	-	endopeptidase activity	15283675
GO:0004180	IEA	-	carboxypeptidase activity	-
GO:0008144	IDA	-	drug binding	1320019
GO:0008237	IDA	-	metallopeptidase activity	1320019
GO:0008237	ISS	-	metallopeptidase activity	-
GO:0008237	TAS	-	metallopeptidase activity	2554286
GO:0008238	IDA	-	exopeptidase activity	2983326
GO:0008240	IDA	-	tripeptidyl-peptidase activity	2983326
GO:0008241	IDA	-	peptidyl-dipeptidase activity	1320019
GO:0008241	ISS	-	peptidyl-dipeptidase activity	11303049
GO:0008241	TAS	-	peptidyl-dipeptidase activity	2554286
GO:0008270	IDA	-	zinc ion binding	12540854
GO:0031404	IDA	-	chloride ion binding	12540854
GO:0031434	IPI	-	mitogen-activated protein kinase kinase binding	14615289
GO:0031711	IPI	-	bradykinin receptor binding	17077303
GO:0051019	IPI	-	mitogen-activated protein kinase binding	14615289
GO:0070573	EXP	-	metallodipeptidase activity	1848554

GO ID	Evidence	Qualifier	GO_term	References
GO:0001822	IMP	-	kidney development	16116425
GO:0001974	IC	-	blood vessel remodeling	1668266
GO:0002003	TAS	-	angiotensin maturation	-
GO:0002005	IC	-	angiotensin catabolic process in blood	1668266
GO:0002019	IC	-	regulation of renal output by angiotensin	1668266
GO:0002446	ISS	-	neutrophil mediated immunity	-
GO:0002474	TAS	-	antigen processing and presentation of peptide antigen via MHC class I	23257181
GO:0003081	IC	-	regulation of systemic arterial blood pressure by renin-angiotensin	1668266
GO:0003081	IMP	-	regulation of systemic arterial blood pressure by renin-angiotensin	174834
GO:0006508	TAS	-	proteolysis	2554286
GO:0007283	ISS	-	spermatogenesis	-
GO:0008217	ISS	-	regulation of blood pressure	11303049
GO:0014910	ISS	-	regulation of smooth muscle cell migration	-
GO:0019229	IC	-	regulation of vasoconstriction	1668266
GO:0032943	IC	-	mononuclear cell proliferation	7876104
GO:0042447	IDA	-	hormone catabolic process	7876104
GO:0042447	ISS	-	hormone catabolic process	11303049
GO:0043171	IDA	-	peptide catabolic process	4322742
GO:0050435	IDA	-	amyloid-beta metabolic process	18495113
GO:0050482	IDA	-	arachidonic acid secretion	17077303
GO:0060047	ISS	-	heart contraction	-
GO:0060177	IDA	-	regulation of angiotensin metabolic process	1851160
GO:0060218	IC	-	hematopoietic stem cell differentiation	7876104
GO:0061098	ISS	-	positive regulation of protein tyrosine kinase activity	-
GO:0071838	ISS	-	cell proliferation in bone marrow	-
GO:0097746	IC	-	regulation of blood vessel diameter	4322742
GO:1900086	ISS	-	positive regulation of peptidyl-tyrosine autophosphorylation	-
GO:1902033	IC	-	regulation of hematopoietic stem cell proliferation	7876104
GO:1902033	ISS	-	regulation of hematopoietic stem cell proliferation	-
GO:1903597	ISS	-	negative regulation of gap junction assembly	-
GO:2000170	ISS	-	positive regulation of peptidyl-cysteine S-nitrosylation	-

AutismKB 2.0

Annotation Details for ACE