AutismKB 2.0

Annotation Details for AKR1C2


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Basic Information Top
Gene Symbol:AKR1C2 ( AKR1C-pseudo,BABP,DD,DD2,DDH2,FLJ53800,HAKRD,HBAB,MCDR2 )
Gene Full Name: aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
Band: 10p15.1
Quick LinksEntrez ID:1646; OMIM: 600450; Uniprot ID:AK1C2_HUMAN; ENSEMBL ID: ENSG00000151632; HGNC ID: 385
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IEA-cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0004032IDA-alditol:NADP+ 1-oxidoreductase activity21232532
GO:0016655IDA-oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor20837989
GO:0018636IDA-phenanthrene 9,10-monooxygenase activity21851338
GO:0031406IDA-carboxylic acid binding8573067
GO:0032052IDA-bile acid binding8573067
GO:0047086IDA-ketosteroid monooxygenase activity21232532
GO:0047115IDA-trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity8573067
GO ID Evidence Qualifier GO_term References
GO:0006693IDA-prostaglandin metabolic process8573067
GO:0007186IDA-G-protein coupled receptor signaling pathway18508192
GO:0007586IDA-digestion8573067
GO:0008202IDA-steroid metabolic process8573067
GO:0008284IDA-positive regulation of cell proliferation18508192
GO:0030855IEP-epithelial cell differentiation21492153
GO:0042448IDA-progesterone metabolic process21232532
GO:0044597IMP-daunorubicin metabolic process20837989
GO:0044598IMP-doxorubicin metabolic process20837989
GO:0051897IDA-positive regulation of protein kinase B signaling18508192
GO:0055114IDA-oxidation-reduction process21232532
GO:0071395IDA-cellular response to jasmonic acid stimulus19487289
GO:0071799IDA-cellular response to prostaglandin D stimulus18508192
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
AKR1C2AKR1C210801311514561 Co-crystal Structure
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1924587
  • Data Attributes: HomoloGene calculated
No data
No data

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018