AutismKB 2.0

Annotation Details for DDIT3


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Basic Information Top
Gene Symbol:DDIT3 ( CEBPZ,CHOP,CHOP-10,CHOP10,GADD153,MGC4154 )
Gene Full Name: DNA-damage-inducible transcript 3
Band: 12q13.3
Quick LinksEntrez ID:1649; OMIM: 126337; Uniprot ID:DDIT3_HUMAN; ENSEMBL ID: ENSG00000175197; HGNC ID: 2726
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus11478948
GO:0005654TAS-nucleoplasm-
GO:0005770IEA-late endosome-
GO:0005829TAS-cytosol14685163
GO:0032993IDA-protein-DNA complex15322075
GO:0035976ISScolocalizes_withtranscription factor AP-1 complex-
GO:0036488ISS-CHOP-C/EBP complex-
GO:0036488TAS-CHOP-C/EBP complex14685163
GO:1990617IDA-CHOP-ATF4 complex11478948
GO:1990617IPI-CHOP-ATF4 complex18940792
GO:1990622IDA-CHOP-ATF3 complex8622660
GO ID Evidence Qualifier GO_term References
GO:0000976IDA-transcription regulatory region sequence-specific DNA binding24939851
GO:0000978IDA-RNA polymerase II core promoter proximal region sequence-specific DNA binding22065586
GO:0001077IDA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding22065586
GO:0003677IDA-DNA binding14667815
GO:0003700IC-transcription factor activity, sequence-specific DNA binding15322075
GO:0003700IGI-transcription factor activity, sequence-specific DNA binding24939851
GO:0003714TAS-transcription corepressor activity7503811
GO:0005515IPI-protein binding15775988
GO:0008134IPI-transcription factor binding16434966
GO:0008140IPI-cAMP response element binding protein binding11478948
GO:0042803IDA-protein homodimerization activity18534616
GO:0042803ISSNOTprotein homodimerization activity-
GO:0043522IDA-leucine zipper domain binding8622660
GO:0044212IC-transcription regulatory region DNA binding15322075
GO:0044212ISS-transcription regulatory region DNA binding-
GO:0046982IPI-protein heterodimerization activity8622660
GO:0046982NAS-protein heterodimerization activity15775988
GO:0046982TAS-protein heterodimerization activity14685163
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter18940792
GO:0000122IGI-negative regulation of transcription from RNA polymerase II promoter11478948
GO:0001955IEA-blood vessel maturation-
GO:0006355IMP-regulation of transcription, DNA-templated17872950
GO:0006974TAS-cellular response to DNA damage stimulus1339368
GO:0006983IEA-ER overload response-
GO:0006986IDA-response to unfolded protein18940792
GO:0007050IDA-cell cycle arrest22496745
GO:0016055IEA-Wnt signaling pathway-
GO:0032757IMP-positive regulation of interleukin-8 production20829347
GO:0032792IDA-negative regulation of CREB transcription factor activity8622660
GO:0032792IGI-negative regulation of CREB transcription factor activity11478948
GO:0034976IDA-response to endoplasmic reticulum stress18940792
GO:0036499TAS-PERK-mediated unfolded protein response14685163
GO:0036500TAS-ATF6-mediated unfolded protein response22934019
GO:0042594IEA-response to starvation-
GO:0042789IDA-mRNA transcription from RNA polymerase II promoter14667815
GO:0043161IDA-proteasome-mediated ubiquitin-dependent protein catabolic process17872950
GO:0043433IDA-negative regulation of sequence-specific DNA binding transcription factor activity16434966
GO:0043433IMP-negative regulation of sequence-specific DNA binding transcription factor activity18534616
GO:0043525IC-positive regulation of neuron apoptotic process22761832
GO:0043620TAS-regulation of DNA-templated transcription in response to stress19816510
GO:0044324ISS-regulation of transcription involved in anterior/posterior axis specification16434966
GO:0045454IDA-cell redox homeostasis14667815
GO:0045599IEA-negative regulation of fat cell differentiation-
GO:0045662IEA-negative regulation of myoblast differentiation-
GO:0045892IDA-negative regulation of transcription, DNA-templated18940792
GO:0045893IDA-positive regulation of transcription, DNA-templated15322075
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter22065586
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter22065586
GO:0051091IMP-positive regulation of sequence-specific DNA binding transcription factor activity18534616
GO:0051209IEA-release of sequestered calcium ion into cytosol-
GO:0051259IDA-protein oligomerization18534616
GO:0051898IMP-negative regulation of protein kinase B signaling22761832
GO:0070059IDA-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress18940792
GO:0070059IMP-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress15322075
GO:0070059TAS-intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress14685163
GO:0072655IEA-establishment of protein localization to mitochondrion-
GO:0090090ISS-negative regulation of canonical Wnt signaling pathway16434966
GO:1902237IC-positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway22761832
GO:1903026IDA-negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding8622660
GO:1990440IDA-positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress15322075
GO:1990440IGI-positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress15775988
GO:1990440IMP-positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress22761832
GO:1990440ISS-positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress-
GO:1990442IEA-intrinsic apoptotic signaling pathway in response to nitrosative stress-
GO:2000016IDA-negative regulation of determination of dorsal identity16434966
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DDIT3ATF31069578622660 Affinity Capture-Western; Reconstituted Complex
DDIT3ATF31080168622660 Affinity Capture-Western; Reconstituted Complex
DDIT3CEBPB1080168662954 12706815 20562859 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
DDIT3CEBPB1074808662954 12706815 20562859 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
DDIT3CEBPG10748312618752 16189514 Affinity Capture-Western; Two-hybrid
DDIT3CEBPG10801612618752 16189514 Affinity Capture-Western; Two-hybrid
DDIT3MAPK141080168650547 Biochemical Activity
DDIT3MAPK141078198650547 Biochemical Activity
DDIT3CSNK2A110801612876286 Biochemical Activity; Reconstituted Complex
DDIT3CSNK2A110784112876286 Biochemical Activity; Reconstituted Complex
PICALMDDIT31139021547942 Affinity Capture-Western
PICALMDDIT31080161547942 Affinity Capture-Western
FOSDDIT310863610523647 Affinity Capture-Western; Reconstituted Complex
FOSDDIT310801610523647 Affinity Capture-Western; Reconstituted Complex
JUNDDIT310992810523647 Affinity Capture-Western; Reconstituted Complex
JUNDDIT310801610523647 Affinity Capture-Western; Reconstituted Complex
JUNDDDIT310801610523647 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
JUNDDDIT310993010523647 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
RPS3ADDIT310801610713066 Affinity Capture-Western; Reconstituted Complex
RPS3ADDIT311210310713066 Affinity Capture-Western; Reconstituted Complex
UBCDDIT311316412618752 Affinity Capture-Western
UBCDDIT310801612618752 Affinity Capture-Western
BATFDDIT310801616189514 Two-hybrid
BATFDDIT311579216189514 Two-hybrid
HSD17B14DDIT311935016189514 Two-hybrid
HSD17B14DDIT310801616189514 Two-hybrid
C10orf119DDIT312297616189514 Two-hybrid
C10orf119DDIT310801616189514 Two-hybrid
SPOPDDIT311399316189514 Two-hybrid
SPOPDDIT310801616189514 Two-hybrid
SSX3DDIT311550920211142 Two-hybrid
SSX3DDIT310801620211142 Two-hybrid
RAI1DDIT311596620211142 Two-hybrid
RAI1DDIT310801620211142 Two-hybrid
HOXA5DDIT310944220211142 Two-hybrid
HOXA5DDIT310801620211142 Two-hybrid
ZNF323DDIT312213020211142 Two-hybrid
ZNF323DDIT310801620211142 Two-hybrid
C14orf80DDIT312962920562859 Affinity Capture-MS
C14orf80DDIT310801620562859 Affinity Capture-MS
LDOC1LDDIT310801620562859 Affinity Capture-MS
LDOC1LDDIT312397520562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109247
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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