AutismKB 2.0

Annotation Details for DDX3X


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Basic Information Top
Gene Symbol:DDX3X ( DBX,DDX14,DDX3,HLP2 )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked
Band: Xp11.4
Quick LinksEntrez ID:1654; OMIM: 300160; Uniprot ID:DDX3X_HUMAN; ENSEMBL ID: ENSG00000215301; HGNC ID: 2745
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus10074132
GO:0005737IDA-cytoplasm10329544
GO:0005737IMP-cytoplasm10074132
GO:0005741IEA-mitochondrial outer membrane-
GO:0005829IDA-cytosol-
GO:0005852IDAcolocalizes_witheukaryotic translation initiation factor 3 complex18628297
GO:0010494IDA-cytoplasmic stress granule18596238
GO:0016607IEA-nuclear speck-
GO:0022627IDAcolocalizes_withcytosolic small ribosomal subunit18596238
GO:0034774TAS-secretory granule lumen-
GO:0070062IDA-extracellular exosome19056867
GO:1904813TAS-ficolin-1-rich granule lumen-
GO ID Evidence Qualifier GO_term References
GO:0003677IDA-DNA binding21589879
GO:0003723IDA-RNA binding21589879
GO:0003924IDA-GTPase activity10074132
GO:0004003IDA-ATP-dependent DNA helicase activity21589879
GO:0004004IDA-ATP-dependent RNA helicase activity21589879
GO:0005515IPI-protein binding10074132
GO:0005524IEA-ATP binding-
GO:0008134IDA-transcription factor binding16818630
GO:0008143IDA-poly(A) binding18596238
GO:0008190IDA-eukaryotic initiation factor 4E binding17667941
GO:0016887IDA-ATPase activity10074132
GO:0017111IDA-nucleoside-triphosphatase activity10074132
GO:0031369IDA-translation initiation factor binding22323517
GO:0033592IDA-RNA strand annealing activity27546789
GO:0035613IDA-RNA stem-loop binding22872150
GO:0043024IDA-ribosomal small subunit binding22323517
GO:0043273IDA-CTPase activity10074132
GO:0045296IDA-cadherin binding25468996
GO:0048027IDA-mRNA 5'-UTR binding22872150
GO ID Evidence Qualifier GO_term References
GO:0006351IEA-transcription, DNA-templated-
GO:0007059IMP-chromosome segregation21730191
GO:0008625IMP-extrinsic apoptotic signaling pathway via death domain receptors18846110
GO:0009615IDA-response to virus18636090
GO:0010501IDA-RNA secondary structure unwinding22872150
GO:0010628IDA-positive regulation of gene expression10074132
GO:0016055IMP-Wnt signaling pathway26235985
GO:0017148IMP-negative regulation of translation17667941
GO:0030307IMP-positive regulation of cell growth18628297
GO:0030308IDA-negative regulation of cell growth16818630
GO:0031333IDA-negative regulation of protein complex assembly17667941
GO:0032508IEA-DNA duplex unwinding-
GO:0032728TAS-positive regulation of interferon-beta production18583960
GO:0034063IDA-stress granule assembly21883093
GO:0035556IDA-intracellular signal transduction18636090
GO:0042256IMP-mature ribosome assembly22323517
GO:0043065IMP-positive regulation of apoptotic process16301996
GO:0043066IMP-negative regulation of apoptotic process18846110
GO:0043154IMP-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process18846110
GO:0043280IMP-positive regulation of cysteine-type endopeptidase activity involved in apoptotic process16301996
GO:0043312TAS-neutrophil degranulation-
GO:0045070IMP-positive regulation of viral genome replication20862261
GO:0045087IMP-innate immune response18583960
GO:0045727IDA-positive regulation of translation18596238
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter16818630
GO:0045944IMP-positive regulation of transcription from RNA polymerase II promoter18583960
GO:0045948IMP-positive regulation of translational initiation20837705
GO:0071243IDA-cellular response to arsenic-containing substance21883093
GO:0071470IDA-cellular response to osmotic stress21883093
GO:0071651TAS-positive regulation of chemokine (C-C motif) ligand 5 production18583960
GO:0097193IMP-intrinsic apoptotic signaling pathway16301996
GO:1900087IMP-positive regulation of G1/S transition of mitotic cell cycle20837705
GO:1903608IMP-protein localization to cytoplasmic stress granule24965446
GO:2001243IMP-negative regulation of intrinsic apoptotic signaling pathway21883093
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DDX3XAPBB110681916055720 Affinity Capture-MS
DDX3XAPBB110802016055720 Affinity Capture-MS
DDX3XCD4010802017353931 Affinity Capture-MS
DDX3XCD4010739617353931 Affinity Capture-MS
NFKB2DDX3X11085814743216 Affinity Capture-MS
NFKB2DDX3X10802014743216 Affinity Capture-MS
WBP4DDX3X11636316055720 Affinity Capture-MS
WBP4DDX3X10802016055720 Affinity Capture-MS
NEDD4DDX3X10802016055720 Affinity Capture-MS
NEDD4DDX3X11081116055720 Affinity Capture-MS
PIN1DDX3X11131716055720 Affinity Capture-MS
PIN1DDX3X10802016055720 Affinity Capture-MS
SRRM2DDX3X11707116159877 Affinity Capture-MS
SRRM2DDX3X10802016159877 Affinity Capture-MS
SAP18DDX3X11557317353931 Affinity Capture-MS
SAP18DDX3X10802017353931 Affinity Capture-MS
EIF4A2DDX3X10802017353931 Affinity Capture-MS
EIF4A2DDX3X10829017353931 Affinity Capture-MS
ELF3DDX3X10802017353931 Affinity Capture-MS
ELF3DDX3X10831417353931 Affinity Capture-MS
PUF60DDX3X11650217353931 Affinity Capture-MS
PUF60DDX3X10802017353931 Affinity Capture-MS
ILKDDX3X10982417353931 Affinity Capture-MS
ILKDDX3X10802017353931 Affinity Capture-MS
C20orf24DDX3X12101517353931 Affinity Capture-MS
C20orf24DDX3X10802017353931 Affinity Capture-MS
TRAF6DDX3X11304117353931 Affinity Capture-MS
TRAF6DDX3X10802017353931 Affinity Capture-MS
DYNLL1DDX3X11420617353931 Affinity Capture-MS
DYNLL1DDX3X10802017353931 Affinity Capture-MS
SUMO2DDX3X11249719394292 Affinity Capture-MS
SUMO2DDX3X10802019394292 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:103064
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-1565'