AutismKB 2.0

Annotation Details for DDX5


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Basic Information Top
Gene Symbol:DDX5 ( DKFZp434E109,DKFZp686J01190,G17P1,HLR1,HUMP68,p68 )
Gene Full Name: DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
Band: 17q23.3
Quick LinksEntrez ID:1655; OMIM: 180630; Uniprot ID:DDX5_HUMAN; ENSEMBL ID: ENSG00000108654; HGNC ID: 2746
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16791210
GO:0005634NAS-nucleus2451786
GO:0005654TAS-nucleoplasm-
GO:0005730IDA-nucleolus10837141
GO:0016020IDA-membrane19946888
GO:0030529IDA-intracellular ribonucleoprotein complex18809582
GO:0031012IDA-extracellular matrix23979707
GO:0070062IDA-extracellular exosome19056867
GO:0071013IDA-catalytic step 2 spliceosome11991638
GO:0071141IDAcolocalizes_withSMAD protein complex18548003
GO ID Evidence Qualifier GO_term References
GO:0003713IDA-transcription coactivator activity-
GO:0003723IDA-RNA binding22658674
GO:0003724IMP-RNA helicase activity21343338
GO:0003724NAS-RNA helicase activity1996094
GO:0003730IDA-mRNA 3'-UTR binding23788676
GO:0004004IBA-ATP-dependent RNA helicase activity-
GO:0005515IPI-protein binding10837141
GO:0005516IEA-calmodulin binding-
GO:0005524IEA-ATP binding-
GO:0019899IEA-enzyme binding-
GO:0030331IDA-estrogen receptor binding-
GO:0035500IPI-MH2 domain binding18548003
GO:0036002IDA-pre-mRNA binding21343338
GO:0043021IDA-ribonucleoprotein complex binding23788676
GO:0046332IPI-SMAD binding18548003
GO:0048306IEA-calcium-dependent protein binding-
GO:0050681IDA-androgen receptor binding18829551
GO:0070412IPI-R-SMAD binding18548003
GO:0070878IDA-primary miRNA binding18548003
GO:1990841ISS-promoter-specific chromatin binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter15298701
GO:0000380IMP-alternative mRNA splicing, via spliceosome24275493
GO:0000381IDA-regulation of alternative mRNA splicing, via spliceosome21343338
GO:0000381IMP-regulation of alternative mRNA splicing, via spliceosome23022728
GO:0000398IC-mRNA splicing, via spliceosome11991638
GO:0000398TAS-mRNA splicing, via spliceosome-
GO:0000956IDA-nuclear-transcribed mRNA catabolic process23788676
GO:0001837IMP-epithelial to mesenchymal transition24910439
GO:0006357IMP-regulation of transcription from RNA polymerase II promoter24275493
GO:0009299IMP-mRNA transcription23143267
GO:0010501IBA-RNA secondary structure unwinding-
GO:0016049NAS-cell growth2451786
GO:0030509IMP-BMP signaling pathway18548003
GO:0030520IMP-intracellular estrogen receptor signaling pathway24275493
GO:0030521IMP-androgen receptor signaling pathway24275493
GO:0033148IDA-positive regulation of intracellular estrogen receptor signaling pathway-
GO:0043517IMP-positive regulation of DNA damage response, signal transduction by p53 class mediator15660129
GO:0045069IEA-regulation of viral genome replication-
GO:0045445ISS-myoblast differentiation-
GO:0045667ISS-regulation of osteoblast differentiation-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048511IEA-rhythmic process-
GO:0060765IMP-regulation of androgen receptor signaling pathway18829551
GO:0061614ISS-pri-miRNA transcription from RNA polymerase II promoter-
GO:0072332IMP-intrinsic apoptotic signaling pathway by p53 class mediator15660129
GO:1902893IMPNOTregulation of pri-miRNA transcription from RNA polymerase II promoter18548003
GO:1903800IMP-positive regulation of production of miRNAs involved in gene silencing by miRNA18548003
GO:2001014ISS-regulation of skeletal muscle cell differentiation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DDX5AIRE10682320085707 Affinity Capture-MS; Affinity Capture-Western
DDX5AIRE10802120085707 Affinity Capture-MS; Affinity Capture-Western
DDX5CDK910745917643375 Affinity Capture-MS
DDX5CDK910802117643375 Affinity Capture-MS
DDX5CREBBP10777712527917 Affinity Capture-Western
DDX5CREBBP10802112527917 Affinity Capture-Western
ESR1DDX510802110409727 11250900 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
ESR1DDX510840310409727 11250900 Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
FBLDDX510802110837141 Affinity Capture-Western; Two-hybrid
FBLDDX510839910837141 Affinity Capture-Western; Two-hybrid
SRA1DDX510802111250900 Phenotypic Enhancement
SRA1DDX511532911250900 Phenotypic Enhancement
NCOA2DDX510802111250900 Phenotypic Enhancement; Reconstituted Complex
NCOA2DDX511576111250900 Phenotypic Enhancement; Reconstituted Complex
NCOA3DDX511384111250900 Phenotypic Enhancement; Reconstituted Complex
NCOA3DDX510802111250900 Phenotypic Enhancement; Reconstituted Complex
NCOA1DDX510802111250900 Phenotypic Enhancement; Reconstituted Complex
NCOA1DDX511420011250900 Phenotypic Enhancement; Reconstituted Complex
DDX17DDX511577611250900 Phenotypic Suppression
DDX17DDX510802111250900 Phenotypic Suppression
ESR2DDX510840411250900 Reconstituted Complex
ESR2DDX510802111250900 Reconstituted Complex
AKAP8DDX510802111279182 Far Western; Two-hybrid
AKAP8DDX511556111279182 Far Western; Two-hybrid
EP300DDX510834712527917 Affinity Capture-Western
EP300DDX510802112527917 Affinity Capture-Western
HDAC1DDX510802115298701 20022962 Affinity Capture-Western
HDAC1DDX510931515298701 20022962 Affinity Capture-Western
PIN1DDX511131716055720 Affinity Capture-MS
PIN1DDX510802116055720 Affinity Capture-MS
SRRM1DDX511554416159877 Affinity Capture-MS
SRRM1DDX510802116159877 Affinity Capture-MS
SRRM2DDX511707116159877 Affinity Capture-MS
SRRM2DDX510802116159877 Affinity Capture-MS
MGMTDDX511041116226712 Affinity Capture-MS
MGMTDDX510802116226712 Affinity Capture-MS
MYOD1DDX511073717011493 Affinity Capture-Western
MYOD1DDX510802117011493 Affinity Capture-Western
POLR2ADDX510802117011493 Affinity Capture-Western
POLR2ADDX511142617011493 Affinity Capture-Western
SMARCA4DDX511248117011493 Affinity Capture-Western
SMARCA4DDX510802117011493 Affinity Capture-Western
TBPDDX510802117011493 Affinity Capture-Western
TBPDDX511277117011493 Affinity Capture-Western
STK24DDX511401117353931 Affinity Capture-MS
STK24DDX510802117353931 Affinity Capture-MS
KHDRBS2DDX510802117643375 Affinity Capture-MS
KHDRBS2DDX512843617643375 Affinity Capture-MS
HNRNPA1DDX510942017643375 Affinity Capture-MS
HNRNPA1DDX510802117643375 Affinity Capture-MS
HNRNPH1DDX510942817643375 Affinity Capture-MS
HNRNPH1DDX510802117643375 Affinity Capture-MS
IPO11DDX511936817643375 Affinity Capture-MS
IPO11DDX510802117643375 Affinity Capture-MS
MEPCEDDX512112217643375 Affinity Capture-MS
MEPCEDDX510802117643375 Affinity Capture-MS
TCEA1DDX510802117643375 Affinity Capture-MS
TCEA1DDX511277917643375 Affinity Capture-MS
OTUB1DDX510802118954305 Affinity Capture-MS
OTUB1DDX512075118954305 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:105037
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-925'