AutismKB 2.0

Annotation Details for DLG1


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Basic Information Top
Gene Symbol:DLG1 ( DKFZp761P0818,DKFZp781B0426,DLGH1,SAP-97,SAP97,dJ1061C18.1.1,hdlg )
Gene Full Name: discs, large homolog 1 (Drosophila)
Band: 3q29
Quick LinksEntrez ID:1739; OMIM: 601014; Uniprot ID:DLG1_HUMAN; ENSEMBL ID: ENSG00000075711; HGNC ID: 2900
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001772IDA-immunological synapse20551903
GO:0001772TAS-immunological synapse19841189
GO:0005605IEA-basal lamina-
GO:0005634IDA-nucleus17237226
GO:0005737IDA-cytoplasm17237226
GO:0005783IDA-endoplasmic reticulum21615688
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005794IDA-Golgi apparatus21615688
GO:0005829TAS-cytosol-
GO:0005874IDA-microtubule21615688
GO:0005886TAS-plasma membrane-
GO:0005911IDA-cell-cell junction21615688
GO:0005923IDA-bicellular tight junction17332497
GO:0008328IBAcolocalizes_withionotropic glutamate receptor complex-
GO:0009898IDA-cytoplasmic side of plasma membrane21615688
GO:0014069IBA-postsynaptic density-
GO:0014704TAS-intercalated disc21164104
GO:0016323IDA-basolateral plasma membrane8922391
GO:0016328IEA-lateral plasma membrane-
GO:0030054IDA-cell junction12857860
GO:0031253IEA-cell projection membrane-
GO:0031594IEA-neuromuscular junction-
GO:0033268IEA-node of Ranvier-
GO:0035748IEA-myelin sheath abaxonal region-
GO:0042383IEA-sarcolemma-
GO:0043219IEA-lateral loop-
GO:0045121IEA-membrane raft-
GO:0045211IBA-postsynaptic membrane-
GO:0048471IDA-perinuclear region of cytoplasm21615688
GO:0070062IDA-extracellular exosome20458337
GO:0097025IDA-MPP7-DLG1-LIN7 complex17237226
GO ID Evidence Qualifier GO_term References
GO:0004385TAS-guanylate kinase activity7937897
GO:0004721TAS-phosphoprotein phosphatase activity15302935
GO:0005515IPI-protein binding8922391
GO:0008022IPI-protein C-terminus binding11274188
GO:0008092TAS-cytoskeletal protein binding8825652
GO:0015276TAS-ligand-gated ion channel activity-
GO:0015459IDA-potassium channel regulator activity12970345
GO:0015459ISS-potassium channel regulator activity25447080
GO:0015459NAS-potassium channel regulator activity10779557
GO:0019901IPI-protein kinase binding9341123
GO:0019902IPI-phosphatase binding10646847
GO:0031434IPI-mitogen-activated protein kinase kinase binding21615688
GO:0032947IEA-protein complex scaffold-
GO:0035255IBA-ionotropic glutamate receptor binding-
GO:0044325IPI-ion channel binding12970345
GO:0045296IDA-cadherin binding25468996
GO:0097016IPI-L27 domain binding17332497
GO ID Evidence Qualifier GO_term References
GO:0000122IMP-negative regulation of transcription from RNA polymerase II promoter20551903
GO:0001658IEA-branching involved in ureteric bud morphogenesis-
GO:0001771IEA-immunological synapse formation-
GO:0001935IDA-endothelial cell proliferation14699157
GO:0002088IEA-lens development in camera-type eye-
GO:0002369IEA-T cell cytokine production-
GO:0006470IEA-protein dephosphorylation-
GO:0007015IDA-actin filament organization14699157
GO:0007093NAS-mitotic cell cycle checkpoint10656683
GO:0007163TAS-establishment or maintenance of cell polarity12766944
GO:0007268IBA-chemical synaptic transmission-
GO:0007399IBA-nervous system development-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0008360IMP-regulation of cell shape20551903
GO:0016032IEA-viral process-
GO:0016337IDA-single organismal cell-cell adhesion14699157
GO:0030432IEA-peristalsis-
GO:0030838IEA-positive regulation of actin filament polymerization-
GO:0030866IDA-cortical actin cytoskeleton organization14699157
GO:0030953IMP-astral microtubule organization20551903
GO:0031579IEA-membrane raft organization-
GO:0031641IEA-regulation of myelination-
GO:0032147IEA-activation of protein kinase activity-
GO:0034220IEA-ion transmembrane transport-
GO:0034629IMP-cellular protein complex localization20551903
GO:0042110IEA-T cell activation-
GO:0042130IEA-negative regulation of T cell proliferation-
GO:0042391IDA-regulation of membrane potential12970345
GO:0042982IEA-amyloid precursor protein metabolic process-
GO:0043113IBA-receptor clustering-
GO:0043268IDA-positive regulation of potassium ion transport12970345
GO:0043622IMP-cortical microtubule organization20551903
GO:0045197IBA-establishment or maintenance of epithelial cell apical/basal polarity-
GO:0045930IMP-negative regulation of mitotic cell cycle10656683
GO:0046037IEA-GMP metabolic process-
GO:0046710IEA-GDP metabolic process-
GO:0048608IEA-reproductive structure development-
GO:0048704IEA-embryonic skeletal system morphogenesis-
GO:0048745IEA-smooth muscle tissue development-
GO:0050680IEA-negative regulation of epithelial cell proliferation-
GO:0051660IMP-establishment of centrosome localization20551903
GO:0051898IEA-negative regulation of protein kinase B signaling-
GO:0060022IEA-hard palate development-
GO:0070373IMP-negative regulation of ERK1 and ERK2 cascade20551903
GO:0070830IDA-bicellular tight junction assembly17332497
GO:0072659IMP-protein localization to plasma membrane17332497
GO:0072659TAS-protein localization to plasma membrane21164104
GO:0090004IDA-positive regulation of establishment of protein localization to plasma membrane12970345
GO:0097120IBA-receptor localization to synapse-
GO:0098911ISS-regulation of ventricular cardiac muscle cell action potential25447080
GO:1901222IMPNOTregulation of NIK/NF-kappaB signaling20551903
GO:1902305TAS-regulation of sodium ion transmembrane transport21164104
GO:1903286ISS-regulation of potassium ion import25447080
GO:1903753IMP-negative regulation of p38MAPK cascade20551903
GO:1903760ISS-regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization25447080
GO:1903764ISS-regulation of potassium ion export across plasma membrane25447080
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DLG1ACTN210808312860415 Affinity Capture-Western
DLG1ACTN210660312860415 Affinity Capture-Western
DLG1APBA110681714960569 Affinity Capture-Western
DLG1APBA110808314960569 Affinity Capture-Western
DLG1ATP2B210808311274188 Two-hybrid
DLG1ATP2B210698111274188 Two-hybrid
DLG1ATP2B410808312511555 Reconstituted Complex
DLG1ATP2B410698312511555 Reconstituted Complex
DLG1CAMK2A10808312933808 Affinity Capture-Western; Biochemical Activity
DLG1CAMK2A10726512933808 Affinity Capture-Western; Biochemical Activity
DLG1CTNNA11078769512503 Affinity Capture-Western
DLG1CTNNA11080839512503 Affinity Capture-Western
EPB41DLG11080837937897 Reconstituted Complex
EPB41DLG11083497937897 Reconstituted Complex
KCNA4DLG11099428938729 11997254 12860415 Affinity Capture-Western; Two-hybrid
KCNA4DLG11080838938729 11997254 12860415 Affinity Capture-Western; Two-hybrid
DLGAP1DLG11146609024696 9115257 9286858 11060025 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
DLGAP1DLG11080839024696 9115257 9286858 11060025 Affinity Capture-Western; Far Western; Reconstituted Complex; Two-hybrid
DLG4DLG11080839286858 Affinity Capture-Western
DLG4DLG11080869286858 Affinity Capture-Western
KCNA3DLG11099419341123 Affinity Capture-Western
KCNA3DLG11080839341123 Affinity Capture-Western
LCKDLG11080839341123 Affinity Capture-Western; Reconstituted Complex
LCKDLG11101249341123 Affinity Capture-Western; Reconstituted Complex
GRIA1DLG11080839677374 11567040 12933808 Affinity Capture-Western; Reconstituted Complex
GRIA1DLG11091479677374 11567040 12933808 Affinity Capture-Western; Reconstituted Complex
GRIK2DLG11080839808460 11279111 Affinity Capture-Western
GRIK2DLG11091559808460 11279111 Affinity Capture-Western
KCNJ6DLG110808310619846 Reconstituted Complex
KCNJ6DLG110996510619846 Reconstituted Complex
KIF13BDLG111689510859302 Affinity Capture-Western; Reconstituted Complex
KIF13BDLG110808310859302 Affinity Capture-Western; Reconstituted Complex
CASKDLG110808310993877 12151521 14960569 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CASKDLG111414110993877 12151521 14960569 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CACNG2DLG111564811140673 Affinity Capture-Western
CACNG2DLG110808311140673 Affinity Capture-Western
KCNJ12DLG110808311181181 14960569 15024025 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
KCNJ12DLG110997011181181 14960569 15024025 Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
KCNJ4DLG110808311181181 14960569 15024025 Affinity Capture-Western; Reconstituted Complex
KCNJ4DLG110996311181181 14960569 15024025 Affinity Capture-Western; Reconstituted Complex
KCNJ2DLG110808311181181 Reconstituted Complex
KCNJ2DLG110996111181181 Reconstituted Complex
LRRC1DLG110808311440998 Two-hybrid
LRRC1DLG112052211440998 Two-hybrid
GUCY1A2DLG110808311572861 Affinity Capture-Western
GUCY1A2DLG110923211572861 Affinity Capture-Western
TJAP1DLG110808311602598 Affinity Capture-Western; Two-hybrid
TJAP1DLG112504311602598 Affinity Capture-Western; Two-hybrid
EZRDLG110808311726633 Reconstituted Complex
EZRDLG111327111726633 Reconstituted Complex
GRIN2BDLG110808311997254 Affinity Capture-Western
GRIN2BDLG110916111997254 Affinity Capture-Western
CRIPTDLG111481212070168 Reconstituted Complex
CRIPTDLG110808312070168 Reconstituted Complex
ERBB4DLG110808312175853 Affinity Capture-Western
ERBB4DLG110837812175853 Affinity Capture-Western
ADAM17DLG111273112668732 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ADAM17DLG110808312668732 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BTRCDLG110808312902344 Affinity Capture-Western; Reconstituted Complex
BTRCDLG111445712902344 Affinity Capture-Western; Reconstituted Complex
GRIN2ADLG110808312933808 Affinity Capture-Western; Reconstituted Complex
GRIN2ADLG110916012933808 Affinity Capture-Western; Reconstituted Complex
KCNA5DLG110994312970345 Affinity Capture-Western
KCNA5DLG110808312970345 Affinity Capture-Western
LIN7CDLG110808314960569 Affinity Capture-Western
LIN7CDLG112060814960569 Affinity Capture-Western
LIN7ADLG110808314960569 Affinity Capture-Western
LIN7ADLG111435214960569 Affinity Capture-Western
GPR124DLG110808315021905 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GPR124DLG111745015021905 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MARCH2DLG110808317980554 Affinity Capture-Western
MARCH2DLG111941317980554 Affinity Capture-Western
UBCDLG110808317980554 Affinity Capture-Western
UBCDLG111316417980554 Affinity Capture-Western
AMOTDLG110808319615732 Affinity Capture-MS
AMOTDLG112755719615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
DLG1rs10489880, rs11710576, rs13323530, rs1949471, rs2044862, rs2122824, rs338187, rs338217, rs382579, rs436564, rs447337, rs4635680, rs4916461, rs6583200, rs6805920, rs7616588, rs7628045, rs7638423, rs7650753, rs9839886, rs9843659, rs9857189, rs9868546 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:107231
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-010724-8'