AutismKB 2.0

Annotation Details for DLG4


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Basic Information Top
Gene Symbol:DLG4 ( FLJ97752,FLJ98574,PSD95,SAP-90,SAP90 )
Gene Full Name: discs, large homolog 4 (Drosophila)
Band: 17p13.1
Quick LinksEntrez ID:1742; OMIM: 602887; Uniprot ID:DLG4_HUMAN; ENSEMBL ID: ENSG00000132535; HGNC ID: 2903
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737ISS-cytoplasm-
GO:0005783ISS-endoplasmic reticulum-
GO:0005829TAS-cytosol-
GO:0005886ISScolocalizes_withplasma membrane-
GO:0005886TAS-plasma membrane-
GO:0008021ISS-synaptic vesicle-
GO:0008076ISScolocalizes_withvoltage-gated potassium channel complex-
GO:0008328IBAcolocalizes_withionotropic glutamate receptor complex-
GO:0008328ISScolocalizes_withionotropic glutamate receptor complex-
GO:0014069IBA-postsynaptic density-
GO:0014069ISS-postsynaptic density-
GO:0016323IBA-basolateral plasma membrane-
GO:0030054ISS-cell junction-
GO:0030666TAS-endocytic vesicle membrane-
GO:0030863IDA-cortical cytoskeleton12151521
GO:0031234ISS-extrinsic component of cytoplasmic side of plasma membrane-
GO:0032281ISS-AMPA glutamate receptor complex-
GO:0032839ISS-dendrite cytoplasm-
GO:0043197ISS-dendritic spine-
GO:0044224ISS-juxtaparanode region of axon-
GO:0044300IEA-cerebellar mossy fiber-
GO:0044306ISS-neuron projection terminus-
GO:0044309ISS-neuron spine-
GO:0045202IDA-synapse15496675
GO:0045211IDA-postsynaptic membrane12151521
GO:0060076ISS-excitatory synapse-
GO:0098839IEA-postsynaptic density membrane-
GO ID Evidence Qualifier GO_term References
GO:0004385IBA-guanylate kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005515IPI-protein binding7477295
GO:0008022IPI-protein C-terminus binding7477295
GO:0015276TAS-ligand-gated ion channel activity-
GO:0019900IDA-kinase binding21119615
GO:0019903ISS-protein phosphatase binding-
GO:0030165ISS-PDZ domain binding-
GO:0031697ISS-beta-1 adrenergic receptor binding-
GO:0031748ISS-D1 dopamine receptor binding-
GO:0031812ISS-P2Y1 nucleotide receptor binding-
GO:0032403ISS-protein complex binding-
GO:0033130ISS-acetylcholine receptor binding-
GO:0035255IBA-ionotropic glutamate receptor binding-
GO:0035255ISS-ionotropic glutamate receptor binding-
GO:0097109ISS-neuroligin family protein binding-
GO:0097110ISS-scaffold protein binding-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0002091ISS-negative regulation of receptor internalization-
GO:0006461IDA-protein complex assembly15496675
GO:0007165TAS-signal transduction10364559
GO:0007204ISS-positive regulation of cytosolic calcium ion concentration-
GO:0007268IBA-chemical synaptic transmission-
GO:0007399TAS-nervous system development9286702
GO:0007612TAS-learning9853749
GO:0016188ISS-synaptic vesicle maturation-
GO:0034220IEA-ion transmembrane transport-
GO:0035176IEA-social behavior-
GO:0035418IDA-protein localization to synapse15496675
GO:0035641IEA-locomotory exploration behavior-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045184IDA-establishment of protein localization15496675
GO:0045197IBA-establishment or maintenance of epithelial cell apical/basal polarity-
GO:0046037IEA-GMP metabolic process-
GO:0046710IEA-GDP metabolic process-
GO:0048169ISS-regulation of long-term neuronal synaptic plasticity-
GO:0050806ISS-positive regulation of synaptic transmission-
GO:0050885IEA-neuromuscular process controlling balance-
GO:0060997ISS-dendritic spine morphogenesis-
GO:0071625IEA-vocalization behavior-
GO:0097113ISS-AMPA glutamate receptor clustering-
GO:0097113TAS-AMPA glutamate receptor clustering19914352
GO:0097120IBA-receptor localization to synapse-
GO:0097120ISS-receptor localization to synapse-
GO:2000310ISS-regulation of NMDA receptor activity-
GO:2000463ISS-positive regulation of excitatory postsynaptic potential-
GO:2000821IEA-regulation of grooming behavior-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DLG4ACTN210808612435606 Reconstituted Complex
DLG4ACTN210660312435606 Reconstituted Complex
DLG4ADRB110808610995758 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DLG4ADRB110666210995758 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DLG4BAI110808611937501 Affinity Capture-Western
DLG4BAI110705111937501 Affinity Capture-Western
DLG4DLG11080839286858 Affinity Capture-Western
DLG4DLG11080869286858 Affinity Capture-Western
DLG4DLG21080849182804 Affinity Capture-Western
DLG4DLG21080869182804 Affinity Capture-Western
DLG4DLG310808510026200 Reconstituted Complex; Two-hybrid
DLG4DLG310808610026200 Reconstituted Complex; Two-hybrid
GRIN2BDLG41091617569905 9278515 9581762 11937501 11997254 12738960 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2BDLG41080867569905 9278515 9581762 11937501 11997254 12738960 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NOS1DLG41109058625413 9459447 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
NOS1DLG41080868625413 9459447 Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
KCNA4DLG41099428938729 9581762 11997254 12435606 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KCNA4DLG41080868938729 9581762 11997254 12435606 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DLGAP1DLG41146609024696 9115257 9286858 10527873 10844022 11060025 Affinity Capture-Western; Co-fractionation; Far Western; Reconstituted Complex; Two-hybrid
DLGAP1DLG41080869024696 9115257 9286858 10527873 10844022 11060025 Affinity Capture-Western; Co-fractionation; Far Western; Reconstituted Complex; Two-hybrid
DLGAP2DLG41146599115257 Reconstituted Complex; Two-hybrid
DLGAP2DLG41080869115257 Reconstituted Complex; Two-hybrid
DLGAP4DLG41165139115257 Two-hybrid
DLGAP4DLG41080869115257 Two-hybrid
DLGAP3DLG41218399115257 Two-hybrid
DLGAP3DLG41080869115257 Two-hybrid
DLG4DLG41080869182804 Affinity Capture-Western
GRIN2ADLG41091609278515 9286858 10648730 11937501 12419528 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GRIN2ADLG41080869278515 9286858 10648730 11937501 12419528 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NLGN1DLG41165389278515 Reconstituted Complex; Two-hybrid
NLGN1DLG41080869278515 Reconstituted Complex; Two-hybrid
NLGN3DLG41199449278515 Two-hybrid
NLGN3DLG41080869278515 Two-hybrid
NLGN2DLG41216119278515 Two-hybrid
NLGN2DLG41080869278515 Two-hybrid
SYNGAP1DLG41143589581761 Two-hybrid
SYNGAP1DLG41080869581761 Two-hybrid
CRIPTDLG41148129581762 Reconstituted Complex
CRIPTDLG41080869581762 Reconstituted Complex
MAP1ADLG41103039786987 Two-hybrid
MAP1ADLG41080869786987 Two-hybrid
GRIK2DLG41091559808460 11279111 12597860 Affinity Capture-Western; Reconstituted Complex
GRIK2DLG41080869808460 11279111 12597860 Affinity Capture-Western; Reconstituted Complex
GRIK5DLG41091589808460 11279111 Affinity Capture-Western; Reconstituted Complex
GRIK5DLG41080869808460 11279111 Affinity Capture-Western; Reconstituted Complex
FYNDLG41080869892651 12419528 Affinity Capture-Western
FYNDLG41088109892651 12419528 Affinity Capture-Western
LIN7BDLG410808610341223 Affinity Capture-Western
LIN7BDLG412207910341223 Affinity Capture-Western
LIN7ADLG411435210341223 Reconstituted Complex
LIN7ADLG410808610341223 Reconstituted Complex
PTPRGDLG411175710521598 Two-hybrid
PTPRGDLG410808610521598 Two-hybrid
SHANK2DLG411659810527873 10844022 Affinity Capture-Western
SHANK2DLG410808610527873 10844022 Affinity Capture-Western
KCNJ2DLG410996110627592 Affinity Capture-Western; Two-hybrid
KCNJ2DLG410808610627592 Affinity Capture-Western; Two-hybrid
KCNJ4DLG410996310627592 11997254 14960569 Affinity Capture-Western; Two-hybrid
KCNJ4DLG410808610627592 11997254 14960569 Affinity Capture-Western; Two-hybrid
ERBB4DLG410808610725395 10839362 Affinity Capture-Western; Co-fractionation; Two-hybrid
ERBB4DLG410837810725395 10839362 Affinity Capture-Western; Co-fractionation; Two-hybrid
LRP2DLG411021610827173 12713445 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LRP2DLG410808610827173 12713445 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LRP1DLG411021510827173 Reconstituted Complex; Two-hybrid
LRP1DLG410808610827173 Reconstituted Complex; Two-hybrid
LRP8DLG411357910827173 Two-hybrid
LRP8DLG410808610827173 Two-hybrid
ERBB2DLG410837610839362 Affinity Capture-Western; Co-fractionation; Two-hybrid
ERBB2DLG410808610839362 Affinity Capture-Western; Co-fractionation; Two-hybrid
DYNLL2DLG410808610844022 Affinity Capture-Western; Reconstituted Complex
DYNLL2DLG412668010844022 Affinity Capture-Western; Reconstituted Complex
DYNLL1DLG411420610844022 Affinity Capture-Western; Reconstituted Complex
DYNLL1DLG410808610844022 Affinity Capture-Western; Reconstituted Complex
KIF13BDLG411689510859302 Reconstituted Complex
KIF13BDLG410808610859302 Reconstituted Complex
SEMA4CDLG412025411134026 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SEMA4CDLG410808611134026 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CACNG2DLG411564811140673 11805122 Affinity Capture-Western; Co-fractionation
CACNG2DLG410808611140673 11805122 Affinity Capture-Western; Co-fractionation
MAP3K10DLG411044011152698 Affinity Capture-Western
MAP3K10DLG410808611152698 Affinity Capture-Western
MAP3K11DLG411044211152698 Affinity Capture-Western
MAP3K11DLG410808611152698 Affinity Capture-Western
NLGN4XDLG412156711368788 Affinity Capture-Western
NLGN4XDLG410808611368788 Affinity Capture-Western
LRRC1DLG412052211440998 Two-hybrid
LRRC1DLG410808611440998 Two-hybrid
GUCY1A2DLG410923211572861 Affinity Capture-Western
GUCY1A2DLG410808611572861 Affinity Capture-Western
PARK2DLG411110511679592 Affinity Capture-Western
PARK2DLG410808611679592 Affinity Capture-Western
CD46DLG411034611714708 Two-hybrid
CD46DLG410808611714708 Two-hybrid
PRKCADLG411156411937501 Affinity Capture-Western
PRKCADLG410808611937501 Affinity Capture-Western
GRIN2CDLG410916211937501 Affinity Capture-Western; Reconstituted Complex
GRIN2CDLG410808611937501 Affinity Capture-Western; Reconstituted Complex
HTR2CDLG410959012006486 Reconstituted Complex
HTR2CDLG410808612006486 Reconstituted Complex
FZD7DLG411392012067714 Affinity Capture-Western; Two-hybrid
FZD7DLG410808612067714 Affinity Capture-Western; Two-hybrid
FZD2DLG410808612067714 Two-hybrid
FZD2DLG410881112067714 Two-hybrid
FZD1DLG411391712067714 Two-hybrid
FZD1DLG410808612067714 Two-hybrid
FZD4DLG411391812067714 Two-hybrid
FZD4DLG410808612067714 Two-hybrid
CASKDLG411414112151521 Affinity Capture-Western; Two-hybrid
CASKDLG410808612151521 Affinity Capture-Western; Two-hybrid
HGSDLG411459312151521 Affinity Capture-Western; Two-hybrid
HGSDLG410808612151521 Affinity Capture-Western; Two-hybrid
LRRC7DLG412161012390249 Affinity Capture-Western
LRRC7DLG410808612390249 Affinity Capture-Western
KCNA5DLG410994312435606 12860415 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KCNA5DLG410808612435606 12860415 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
KCNA1DLG410993912435606 Reconstituted Complex; Two-hybrid
KCNA1DLG410808612435606 Reconstituted Complex; Two-hybrid
KCNA2DLG410994012435606 Reconstituted Complex; Two-hybrid
KCNA2DLG410808612435606 Reconstituted Complex; Two-hybrid
KCND2DLG410995312435606 Two-hybrid
KCND2DLG410808612435606 Two-hybrid
PTK2BDLG410848012576483 Affinity Capture-Western; Reconstituted Complex
PTK2BDLG410808612576483 Affinity Capture-Western; Reconstituted Complex
GRIK1DLG410915412597860 Affinity Capture-Western; Reconstituted Complex
GRIK1DLG410808612597860 Affinity Capture-Western; Reconstituted Complex
EXOC4DLG410808612675619 12738960 Affinity Capture-Western; Reconstituted Complex
EXOC4DLG412190612675619 12738960 Affinity Capture-Western; Reconstituted Complex
HTR2ADLG410958812682061 Affinity Capture-Western
HTR2ADLG410808612682061 Affinity Capture-Western
KCNJ12DLG410997014960569 15024025 Affinity Capture-MS; Affinity Capture-Western
KCNJ12DLG410808614960569 15024025 Affinity Capture-MS; Affinity Capture-Western
ACCN3DLG411472315317815 Affinity Capture-Western
ACCN3DLG410808615317815 Affinity Capture-Western
GRIA2DLG410914816990550 Affinity Capture-MS
GRIA2DLG410808616990550 Affinity Capture-MS
GRIA3DLG410914916990550 Affinity Capture-MS
GRIA3DLG410808616990550 Affinity Capture-MS
ADAM22DLG411978916990550 Affinity Capture-MS; Affinity Capture-Western
ADAM22DLG410808616990550 Affinity Capture-MS; Affinity Capture-Western
LGI1DLG411464516990550 Affinity Capture-MS; Affinity Capture-Western
LGI1DLG410808616990550 Affinity Capture-MS; Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
DLG4rs13331, rs17203281, rs2017365, rs2230178, rs2242449, rs2521985, rs314253, rs390200, rs507506, rs6145976, rs739669 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1277959
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040628-3'