AutismKB 2.0

Annotation Details for DNM2


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Basic Information Top
Gene Symbol:DNM2 ( CMT2M,CMTDI1,CMTDIB,DI-CMTB,DYN2,DYNII )
Gene Full Name: dynamin 2
Band: 19p13.2
Quick LinksEntrez ID:1785; OMIM: 602378; Uniprot ID:DYN2_HUMAN; ENSEMBL ID: ENSG00000079805; HGNC ID: 2974
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000139TAS-Golgi membrane-
GO:0001891IEA-phagocytic cup-
GO:0001917IEA-photoreceptor inner segment-
GO:0005634IEA-nucleus-
GO:0005768IEA-endosome-
GO:0005794IDA-Golgi apparatus-
GO:0005802IEA-trans-Golgi network-
GO:0005813IEA-centrosome-
GO:0005829IDA-cytosol18388313
GO:0005829TAS-cytosol-
GO:0005874IDA-microtubule21525035
GO:0005886TAS-plasma membrane-
GO:0005905ISS-clathrin-coated pit-
GO:0005925IDA-focal adhesion21423176
GO:0014069IEA-postsynaptic density-
GO:0030027IEA-lamellipodium-
GO:0030426ISScolocalizes_withgrowth cone-
GO:0030496IEA-midbody-
GO:0030666TAS-endocytic vesicle membrane-
GO:0030670IEA-phagocytic vesicle membrane-
GO:0031966IBA-mitochondrial membrane-
GO:0032587IEA-ruffle membrane-
GO:0043234IEA-protein complex-
GO:0045211IDA-postsynaptic membrane11583995
GO:0045334IEA-clathrin-coated endocytic vesicle-
GO:0048471IEA-perinuclear region of cytoplasm-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0003924IBA-GTPase activity-
GO:0003924NAS-GTPase activity11583995
GO:0003924TAS-GTPase activity-
GO:0005515IPI-protein binding11583995
GO:0005525NAS-GTP binding7590285
GO:0008017IBA-microtubule binding-
GO:0008017NAS-microtubule binding7590285
GO:0017124IDA-SH3 domain binding18388313
GO:0019899NAS-enzyme binding11583995
GO:0019901IEA-protein kinase binding-
GO:0031749IEA-D2 dopamine receptor binding-
GO:0032403IEA-protein complex binding-
GO:0036312IEA-phosphatidylinositol 3-kinase regulatory subunit binding-
GO:0050699IEA-WW domain binding-
GO:0050998IEA-nitric-oxide synthase binding-
GO ID Evidence Qualifier GO_term References
GO:0000086NAS-G2/M transition of mitotic cell cycle7590285
GO:0000266IBA-mitochondrial fission-
GO:0002031IEA-G-protein coupled receptor internalization-
GO:0003281IEA-ventricular septum development-
GO:0003374IBA-dynamin family protein polymerization involved in mitochondrial fission-
GO:0006355NAS-regulation of transcription, DNA-templated10893263
GO:0006893IEA-Golgi to plasma membrane transport-
GO:0006897NAS-endocytosis10101292
GO:0006898ISS-receptor-mediated endocytosis-
GO:0006909IEA-phagocytosis-
GO:0007165NAS-signal transduction10893263
GO:0007283IEA-spermatogenesis-
GO:0009416IEA-response to light stimulus-
GO:0010592IEA-positive regulation of lamellipodium assembly-
GO:0019886TAS-antigen processing and presentation of exogenous peptide antigen via MHC class II-
GO:0030512IEA-negative regulation of transforming growth factor beta receptor signaling pathway-
GO:0030516ISS-regulation of axon extension-
GO:0031623IMP-receptor internalization14985334
GO:0033572IMP-transferrin transport14985334
GO:0035020IEA-regulation of Rac protein signal transduction-
GO:0035904IEA-aorta development-
GO:0042220IEA-response to cocaine-
GO:0043065NAS-positive regulation of apoptotic process10893263
GO:0044351IEA-macropinocytosis-
GO:0045429IEA-positive regulation of nitric oxide biosynthetic process-
GO:0045893NAS-positive regulation of transcription, DNA-templated10893263
GO:0048489NAS-synaptic vesicle transport11583995
GO:0048812ISS-neuron projection morphogenesis-
GO:0050766IEA-positive regulation of phagocytosis-
GO:0050999TAS-regulation of nitric-oxide synthase activity-
GO:0060976IEA-coronary vasculature development-
GO:0061024TAS-membrane organization-
GO:0061025IBA-membrane fusion-
GO:0071245IEA-cellular response to carbon monoxide-
GO:0071481IEA-cellular response to X-ray-
GO:0071732IEA-cellular response to nitric oxide-
GO:1900026IEA-positive regulation of substrate adhesion-dependent cell spreading-
GO:1902856IEA-negative regulation of non-motile cilium assembly-
GO:1903351IEA-cellular response to dopamine-
GO:1903358IEA-regulation of Golgi organization-
GO:1903408IEA-positive regulation of sodium:potassium-exchanging ATPase activity-
GO:1903526IDA-negative regulation of membrane tubulation18388313
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
FERDNM21085329722593 Co-fractionation
FERDNM21081229722593 Co-fractionation
EPS15DNM210837411483962 Affinity Capture-Western
EPS15DNM210812211483962 Affinity Capture-Western
SHANK2DNM211659811583995 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK2DNM210812211583995 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK1DNM211917111583995 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
SHANK1DNM210812211583995 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PDE6GDNM210812212624098 Reconstituted Complex
PDE6GDNM211117412624098 Reconstituted Complex
SNX9DNM211953512952949 Affinity Capture-MS; Affinity Capture-Western
SNX9DNM210812212952949 Affinity Capture-MS; Affinity Capture-Western
MPP6DNM211967515231747 Two-hybrid
MPP6DNM210812215231747 Two-hybrid
WBP4DNM211636316055720 Affinity Capture-MS
WBP4DNM210812216055720 Affinity Capture-MS
BAT1DNM211364916169070 Two-hybrid
BAT1DNM210812216169070 Two-hybrid
RUVBL2DNM211606717643375 Affinity Capture-MS
RUVBL2DNM210812217643375 Affinity Capture-MS
GTF2E2DNM210921617643375 Affinity Capture-MS
GTF2E2DNM210812217643375 Affinity Capture-MS
MEPCEDNM212112217643375 Affinity Capture-MS
MEPCEDNM210812217643375 Affinity Capture-MS
RPAP2DNM212295917643375 Affinity Capture-MS
RPAP2DNM210812217643375 Affinity Capture-MS
PACSIN2DNM211641319041431 Affinity Capture-MS
PACSIN2DNM210812219041431 Affinity Capture-MS
PACSIN3DNM211889619041431 Affinity Capture-MS
PACSIN3DNM210812219041431 Affinity Capture-MS
PACSIN1DNM211901819041431 Affinity Capture-MS
PACSIN1DNM210812219041431 Affinity Capture-MS
FCHSD1DNM212461919041431 Affinity Capture-MS
FCHSD1DNM210812219041431 Affinity Capture-MS
PSTPIP1DNM211451319041431 Affinity Capture-MS
PSTPIP1DNM210812219041431 Affinity Capture-MS
TRIP10DNM210812219041431 Affinity Capture-MS
TRIP10DNM211473319041431 Affinity Capture-MS
WIPI2DNM211755020562859 Affinity Capture-MS
WIPI2DNM210812220562859 Affinity Capture-MS
Gene Symbol Interactant Interaction ID References Description
GRAP2DNM221652115696170 An unspecified isoform of Dyn2 interacts with Gads. This interaction was modeled on a demonstrated interaction between human Dyn2 and Gads from an unspecified species.
LCKDNM221652215696170 An unspecified isoform of Dyn2 interacts with Lck. This interaction was modeled on a demonstrated interaction between human Dyn2 and Lck from an unspecified species.
VAV1DNM221652415696170 An unspecified isoform of Dyn2 interacts with Vav1.
ABI1DNM221652015696170 An unspecified isoform of Dyn2 interacts with Abi-1. This interaction was modeled on a demonstrated interaction between human Dyn2 and Abi-1 from an unspecified species.
NCK1DNM221651815696170 An unspecified isoform of Dyn2 interacts with Nck. This interaction was modeled on a demonstrated interaction between human Dyn2 and Nck from an unspecified species.
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
DNM2rs10775614, rs11085748, rs1109376, rs12974306, rs2043332, rs34626880, rs3760781, rs3786719, rs3826803, rs714307, rs7246673, rs873016, rs892086 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:109547
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050913-84'