AutismKB 2.0

Annotation Details for DNMT1


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Basic Information Top
Gene Symbol:DNMT1 ( AIM,CXXC9,DNMT,FLJ16293,MCMT,MGC104992 )
Gene Full Name: DNA (cytosine-5-)-methyltransferase 1
Band: 19p13.2
Quick LinksEntrez ID:1786; OMIM: 126375; Uniprot ID:DNMT1_HUMAN; ENSEMBL ID: ENSG00000130816; HGNC ID: 2976
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus16791210
GO:0005654TAS-nucleoplasm-
GO:0005657IEA-replication fork-
GO:0005721IEA-pericentric heterochromatin-
GO ID Evidence Qualifier GO_term References
GO:0003677IDA-DNA binding18754681
GO:0003723IEA-RNA binding-
GO:0003886IDA-DNA (cytosine-5-)-methyltransferase activity21745816
GO:0005515IPI-protein binding16357870
GO:0008270IEA-zinc ion binding-
GO:0008327IEA-methyl-CpG binding-
GO:0009008IDA-DNA-methyltransferase activity18754681
GO:0009008TAS-DNA-methyltransferase activity-
GO:1990841IDA-promoter-specific chromatin binding24623306
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0006306TAS-DNA methylation10888872
GO:0006351IEA-transcription, DNA-templated-
GO:0007265IMP-Ras protein signal transduction24623306
GO:0010216IDA-maintenance of DNA methylation18754681
GO:0010628IMP-positive regulation of gene expression18413740
GO:0016458IEA-gene silencing-
GO:0016569IEA-covalent chromatin modification-
GO:0042127IEA-regulation of cell proliferation-
GO:0043045IEA-DNA methylation involved in embryo development-
GO:0045814TAS-negative regulation of gene expression, epigenetic-
GO:0051571IMP-positive regulation of histone H3-K4 methylation18413740
GO:0051573IMP-negative regulation of histone H3-K9 methylation18413740
GO:0071230IEA-cellular response to amino acid stimulus-
GO:0090116IEA-C-5 methylation of cytosine-
GO:0090309IMP-positive regulation of methylation-dependent chromatin silencing24623306
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DNMT1CHEK110753617991895 Affinity Capture-Western
DNMT1CHEK110812317991895 Affinity Capture-Western
PCNADNMT11081239302295 10888872 12354094 Affinity Capture-Western; Reconstituted Complex
PCNADNMT11111429302295 10888872 12354094 Affinity Capture-Western; Reconstituted Complex
HDAC2DNMT110812310888872 17967891 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC2DNMT110931610888872 17967891 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DMAP1DNMT112100410888872 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
DMAP1DNMT110812310888872 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HDAC1DNMT110812310888886 12473678 15870198 17934516 17967891 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
HDAC1DNMT110931510888886 12473678 15870198 17934516 17967891 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RB1DNMT110812310888886 11847125 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
RB1DNMT111186010888886 11847125 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
E2F1DNMT110820110888886 Co-fractionation
E2F1DNMT110812310888886 Co-fractionation
MBD2DNMT111444510947852 Affinity Capture-Western
MBD2DNMT110812310947852 Affinity Capture-Western
DNMT3ADNMT110812312145218 Affinity Capture-Western; Reconstituted Complex
DNMT3ADNMT110812512145218 Affinity Capture-Western; Reconstituted Complex
DNMT3BDNMT110812612145218 12867029 15120635 Affinity Capture-Western; Reconstituted Complex
DNMT3BDNMT110812312145218 12867029 15120635 Affinity Capture-Western; Reconstituted Complex
MECP2DNMT110812312473678 Affinity Capture-Western; Reconstituted Complex
MECP2DNMT111036812473678 Affinity Capture-Western; Reconstituted Complex
SUV39H1DNMT110812312711675 17085482 Affinity Capture-Western
SUV39H1DNMT111270612711675 17085482 Affinity Capture-Western
CBX1DNMT110812312711675 Reconstituted Complex
CBX1DNMT111615112711675 Reconstituted Complex
CBX5DNMT111703012867029 Affinity Capture-Western
CBX5DNMT110812312867029 Affinity Capture-Western
RGS6DNMT111498714734556 Reconstituted Complex
RGS6DNMT110812314734556 Reconstituted Complex
SMARCA5DNMT110812315313181 Affinity Capture-Western
SMARCA5DNMT111404515313181 Affinity Capture-Western
STAT3DNMT111265115870198 Affinity Capture-Western; Co-localization
STAT3DNMT110812315870198 Affinity Capture-Western; Co-localization
BAZ2ADNMT111634616085498 Reconstituted Complex
BAZ2ADNMT110812316085498 Reconstituted Complex
TRIM27DNMT110812316169070 Two-hybrid
TRIM27DNMT111191916169070 Two-hybrid
EEDDNMT111426516357870 Affinity Capture-Western; Co-localization
EEDDNMT110812316357870 Affinity Capture-Western; Co-localization
EZH2DNMT110812316357870 Affinity Capture-Western; Reconstituted Complex
EZH2DNMT110844616357870 Affinity Capture-Western; Reconstituted Complex
EHMT2DNMT110812317085482 Affinity Capture-Western
EHMT2DNMT111612317085482 Affinity Capture-Western
SP1DNMT111255017124180 Affinity Capture-Western
SP1DNMT110812317124180 Affinity Capture-Western
SP3DNMT111255317124180 Affinity Capture-Western
SP3DNMT110812317124180 Affinity Capture-Western
UHRF1DNMT111889317934516 19800870 19943104 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
UHRF1DNMT110812317934516 19800870 19943104 Affinity Capture-Western; Co-localization; Reconstituted Complex; Two-hybrid
HELLSDNMT110812317967891 Affinity Capture-Western; Reconstituted Complex
HELLSDNMT110932017967891 Affinity Capture-Western; Reconstituted Complex
TP53DNMT111301017991895 Affinity Capture-Western
TP53DNMT110812317991895 Affinity Capture-Western
CXXC1DNMT111904518680430 Affinity Capture-Western
CXXC1DNMT110812318680430 Affinity Capture-Western
SETD7DNMT112333219282482 Affinity Capture-Western; Biochemical Activity
SETD7DNMT110812319282482 Affinity Capture-Western; Biochemical Activity
USP7DNMT110812319615732 Affinity Capture-MS
USP7DNMT111362219615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:94912
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990714-15'