Gene Symbol:	DNMT3A ( DNMT3A2,M.HsaIIIA )
Gene Full Name:	DNA (cytosine-5-)-methyltransferase 3 alpha
Band:	2p23.3
Quick Links	Entrez ID:1788; OMIM: 602769; Uniprot ID:DNM3A_HUMAN; ENSEMBL ID: ENSG00000119772; HGNC ID: 2978
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000775	IEA	-	chromosome, centromeric region	-
GO:0000791	IDA	-	euchromatin	12138111
GO:0001741	IEA	-	XY body	-
GO:0005634	IDA	-	nucleus	12138111
GO:0005654	IDA	-	nucleoplasm	-
GO:0005654	TAS	-	nucleoplasm	-
GO:0005720	IEA	-	nuclear heterochromatin	-
GO:0005737	IDA	-	cytoplasm	12138111
GO:0016363	IDA	-	nuclear matrix	12138111

GO ID	Evidence	Qualifier	GO_term	References
GO:0003677	IDA	-	DNA binding	12138111
GO:0003682	IEA	-	chromatin binding	-
GO:0003886	IDA	-	DNA (cytosine-5-)-methyltransferase activity	12138111
GO:0005515	IPI	-	protein binding	16357870
GO:0009008	TAS	-	DNA-methyltransferase activity	-
GO:0042802	IPI	-	identical protein binding	24656771
GO:0046872	IEA	-	metal ion binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	IEA	-	negative regulation of transcription from RNA polymerase II promoter	-
GO:0000278	IEA	-	mitotic cell cycle	-
GO:0006306	IDA	-	DNA methylation	12138111
GO:0006346	IEA	-	methylation-dependent chromatin silencing	-
GO:0006349	TAS	-	regulation of gene expression by genetic imprinting	12138111
GO:0007283	IEA	-	spermatogenesis	-
GO:0007568	IEA	-	aging	-
GO:0009636	IEA	-	response to toxic substance	-
GO:0010212	IEA	-	response to ionizing radiation	-
GO:0010288	IEA	-	response to lead ion	-
GO:0010942	IEA	-	positive regulation of cell death	-
GO:0030182	IEA	-	neuron differentiation	-
GO:0032355	IEA	-	response to estradiol	-
GO:0033189	IEA	-	response to vitamin A	-
GO:0042220	IEA	-	response to cocaine	-
GO:0042493	IEA	-	response to drug	-
GO:0043045	IEA	-	DNA methylation involved in embryo development	-
GO:0043046	IEA	-	DNA methylation involved in gamete generation	-
GO:0045814	TAS	-	negative regulation of gene expression, epigenetic	-
GO:0071230	IEA	-	cellular response to amino acid stimulus	-
GO:0071361	IEA	-	cellular response to ethanol	-
GO:0071456	IEA	-	cellular response to hypoxia	-
GO:0090116	IEA	-	C-5 methylation of cytosine	-
GO:0097284	IEA	-	hepatocyte apoptotic process	-

Gene Symbol	Interactant	Interaction ID	References	Description
DNMT3A	DNMT1	108123	12145218	Affinity Capture-Western; Reconstituted Complex
DNMT3A	DNMT1	108125	12145218	Affinity Capture-Western; Reconstituted Complex
ZNF238	DNMT3A	115735	11350943	Affinity Capture-Western; Reconstituted Complex
ZNF238	DNMT3A	108125	11350943	Affinity Capture-Western; Reconstituted Complex
HDAC1	DNMT3A	109315	11350943	Affinity Capture-Western; Reconstituted Complex
HDAC1	DNMT3A	108125	11350943	Affinity Capture-Western; Reconstituted Complex
RB1	DNMT3A	111860	11350943	Reconstituted Complex
RB1	DNMT3A	108125	11350943	Reconstituted Complex
DNMT3L	DNMT3A	118984	11934864 17687327	Affinity Capture-Western; Reconstituted Complex
DNMT3L	DNMT3A	108125	11934864 17687327	Affinity Capture-Western; Reconstituted Complex
DNMT3B	DNMT3A	108126	12145218 12867029 14752048	Affinity Capture-Western; Reconstituted Complex
DNMT3B	DNMT3A	108125	12145218 12867029 14752048	Affinity Capture-Western; Reconstituted Complex
SUV39H1	DNMT3A	108125	12711675	Affinity Capture-Western; Reconstituted Complex
SUV39H1	DNMT3A	112706	12711675	Affinity Capture-Western; Reconstituted Complex
CBX1	DNMT3A	108125	12711675	Reconstituted Complex
CBX1	DNMT3A	116151	12711675	Reconstituted Complex
CBX5	DNMT3A	117030	12867029	Affinity Capture-Western
CBX5	DNMT3A	108125	12867029	Affinity Capture-Western
UBE2I	DNMT3A	113177	14752048	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
UBE2I	DNMT3A	108125	14752048	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIAS1	DNMT3A	114124	14752048	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIAS1	DNMT3A	108125	14752048	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIAS2	DNMT3A	114523	14752048	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PIAS2	DNMT3A	108125	14752048	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ZBTB17	DNMT3A	113503	15616584	Affinity Capture-Western
ZBTB17	DNMT3A	108125	15616584	Affinity Capture-Western
MYC	DNMT3A	110694	15616584	Affinity Capture-Western; Reconstituted Complex
MYC	DNMT3A	108125	15616584	Affinity Capture-Western; Reconstituted Complex
RPS8	DNMT3A	112116	15616584	Reconstituted Complex
RPS8	DNMT3A	108125	15616584	Reconstituted Complex
SPI1	DNMT3A	108125	16331260	Affinity Capture-Western; Reconstituted Complex
SPI1	DNMT3A	112566	16331260	Affinity Capture-Western; Reconstituted Complex
EED	DNMT3A	114265	16357870	Affinity Capture-Western; Co-localization
EED	DNMT3A	108125	16357870	Affinity Capture-Western; Co-localization
EZH2	DNMT3A	108125	16357870	Affinity Capture-Western; Reconstituted Complex
EZH2	DNMT3A	108446	16357870	Affinity Capture-Western; Reconstituted Complex
SETDB1	DNMT3A	115202	16682412	Affinity Capture-Western
SETDB1	DNMT3A	108125	16682412	Affinity Capture-Western
CBX4	DNMT3A	114105	17439403	Affinity Capture-Western; Reconstituted Complex
CBX4	DNMT3A	108125	17439403	Affinity Capture-Western; Reconstituted Complex
PRMT5	DNMT3A	108125	19234465	Reconstituted Complex
PRMT5	DNMT3A	115688	19234465	Reconstituted Complex
UHRF1	DNMT3A	118893	19798101	Affinity Capture-Western
UHRF1	DNMT3A	108125	19798101	Affinity Capture-Western
HIST1H3A	DNMT3A	113946	19834512	Reconstituted Complex
HIST1H3A	DNMT3A	108125	19834512	Reconstituted Complex
HIST1H3E	DNMT3A	113949	20223770	Far Western; Reconstituted Complex
HIST1H3E	DNMT3A	108125	20223770	Far Western; Reconstituted Complex

AutismKB 2.0

Annotation Details for DNMT3A

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics