AutismKB 2.0

Annotation Details for DOCK1


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Basic Information Top
Gene Symbol:DOCK1 ( DOCK180,ced5 )
Gene Full Name: dedicator of cytokinesis 1
Band: 10q26.2
Quick LinksEntrez ID:1793; OMIM: 601403; Uniprot ID:DOCK1_HUMAN; ENSEMBL ID: ENSG00000150760; HGNC ID: 2987
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005737IDA-cytoplasm17515907
GO:0005829TAS-cytosol-
GO:0016020IEA-membrane-
GO:0032045IDA-guanyl-nucleotide exchange factor complex12134158
GO ID Evidence Qualifier GO_term References
GO:0005085IDAcontributes_toguanyl-nucleotide exchange factor activity12134158
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity-
GO:0005096IEA-GTPase activator activity-
GO:0005515IPI-protein binding12134158
GO:0017124IEA-SH3 domain binding-
GO ID Evidence Qualifier GO_term References
GO:0006911TAS-phagocytosis, engulfment9548255
GO:0006915IEA-apoptotic process-
GO:0007010IEA-cytoskeleton organization-
GO:0007165TAS-signal transduction8661160
GO:0007229TAS-integrin-mediated signaling pathway9808620
GO:0007264IEA-small GTPase mediated signal transduction-
GO:0007596TAS-blood coagulation-
GO:0010634IMP-positive regulation of epithelial cell migration19004829
GO:0016477IEA-cell migration-
GO:0038096TAS-Fc-gamma receptor signaling pathway involved in phagocytosis-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0048010TAS-vascular endothelial growth factor receptor signaling pathway-
GO:1900026IMP-positive regulation of substrate adhesion-dependent cell spreading19004829
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DOCK1RHOG10812812879077 Affinity Capture-Western
DOCK1RHOG10688412879077 Affinity Capture-Western
DOCK1CRK1081288657152 8662907 10559471 11369773 12615911 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
DOCK1CRK1077888657152 8662907 10559471 11369773 12615911 Affinity Capture-Western; Co-fractionation; Reconstituted Complex
GRB2DOCK11081288657152 12615911 20936779 Co-fractionation; Reconstituted Complex; Two-hybrid
GRB2DOCK11091428657152 12615911 20936779 Co-fractionation; Reconstituted Complex; Two-hybrid
RAC1DOCK11081289808620 Reconstituted Complex
RAC1DOCK11118179808620 Reconstituted Complex
NCK2DOCK111402011240126 Reconstituted Complex
NCK2DOCK110812811240126 Reconstituted Complex
ELMO1DOCK110812811595183 12134158 16495483 Affinity Capture-Western
ELMO1DOCK111518011595183 12134158 16495483 Affinity Capture-Western
PTK2DOCK111171912615911 Affinity Capture-Western
PTK2DOCK110812812615911 Affinity Capture-Western
SRCDOCK111259212615911 Affinity Capture-Western
SRCDOCK110812812615911 Affinity Capture-Western
BCAR1DOCK111493412615911 Affinity Capture-Western; Reconstituted Complex
BCAR1DOCK110812812615911 Affinity Capture-Western; Reconstituted Complex
UBCDOCK111316416495483 Affinity Capture-Western
UBCDOCK110812816495483 Affinity Capture-Western
MEPCEDOCK112112217643375 Affinity Capture-MS
MEPCEDOCK110812817643375 Affinity Capture-MS
MAP1LC3BDOCK110812820562859 Affinity Capture-MS
MAP1LC3BDOCK112356520562859 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2429765
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-080108-5'