AutismKB 2.0

Annotation Details for DOCK2


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Basic Information Top
Gene Symbol:DOCK2 ( FLJ46592,KIAA0209 )
Gene Full Name: dedicator of cytokinesis 2
Band: 5q35.1
Quick LinksEntrez ID:1794; OMIM: 603122; Uniprot ID:DOCK2_HUMAN; ENSEMBL ID: ENSG00000134516; HGNC ID: 2988
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005829TAS-cytosol-
GO:0005856IEA-cytoskeleton-
GO:0016020IDA-membrane19946888
GO:0035580TAS-specific granule lumen-
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0005096IEA-GTPase activator activity-
GO:0005515IPI-protein binding12134158
GO:0030676IDA-Rac guanyl-nucleotide exchange factor activity10559471
GO:0042608IDA-T cell receptor binding12176041
GO ID Evidence Qualifier GO_term References
GO:0001766IEA-membrane raft polarization-
GO:0001768IEA-establishment of T cell polarity-
GO:0001771IEA-immunological synapse formation-
GO:0002277ISS-myeloid dendritic cell activation involved in immune response-
GO:0006935IEA-chemotaxis-
GO:0007264IEA-small GTPase mediated signal transduction-
GO:0030036TAS-actin cytoskeleton organization12176041
GO:0043312TAS-neutrophil degranulation-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0044351ISS-macropinocytosis-
GO:0045059IEA-positive thymic T cell selection-
GO:0045060IEA-negative thymic T cell selection-
GO:0046633IEA-alpha-beta T cell proliferation-
GO:0050690TAS-regulation of defense response to virus by virus-
GO:0050766ISS-positive regulation of phagocytosis-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DOCK2CD24710735712176041 Affinity Capture-Western
DOCK2CD24710812912176041 Affinity Capture-Western
DOCK2CRKL10778912393632 Affinity Capture-Western
DOCK2CRKL10812912393632 Affinity Capture-Western
RAC1DOCK211181710559471 Reconstituted Complex
RAC1DOCK210812910559471 Reconstituted Complex
RAC2DOCK211181810559471 Reconstituted Complex
RAC2DOCK210812910559471 Reconstituted Complex
PAK2DOCK211109812176041 Reconstituted Complex
PAK2DOCK210812912176041 Reconstituted Complex
VAV1DOCK211325212393632 Affinity Capture-Western
VAV1DOCK210812912393632 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2149010
  • Data Attributes: MGI curated and HomoloGene calculated
No data