AutismKB 2.0

Annotation Details for DRD1


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Basic Information Top
Gene Symbol:DRD1 ( DADR,DRD1A )
Gene Full Name: dopamine receptor D1
Band: 5q35.2
Quick LinksEntrez ID:1812; OMIM: 126449; Uniprot ID:DRD1_HUMAN; ENSEMBL ID: ENSG00000184845; HGNC ID: 3020
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IEA-nucleus-
GO:0005789IEA-endoplasmic reticulum membrane-
GO:0005886IDA-plasma membrane11500503
GO:0005886TAS-plasma membrane-
GO:0005887IC-integral component of plasma membrane2144334
GO:0060170IDA-ciliary membrane20531939
GO:0097730IDA-non-motile cilium20531939
GO ID Evidence Qualifier GO_term References
GO:0001588IDA-dopamine neurotransmitter receptor activity, coupled via Gs2144334
GO:0001588IMP-dopamine neurotransmitter receptor activity, coupled via Gs1282671
GO:0004952IDA-dopamine neurotransmitter receptor activity1831904
GO:0005515IPI-protein binding15569306
GO:0035240IMP-dopamine binding1282671
GO ID Evidence Qualifier GO_term References
GO:0001659IEA-temperature homeostasis-
GO:0001661IEA-conditioned taste aversion-
GO:0001662IEA-behavioral fear response-
GO:0001963IEA-synaptic transmission, dopaminergic-
GO:0001975IEA-response to amphetamine-
GO:0006606IEA-protein import into nucleus-
GO:0007187IDA-G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger1282671
GO:0007189IDA-adenylate cyclase-activating G-protein coupled receptor signaling pathway2144334
GO:0007190IDA-activation of adenylate cyclase activity2168520
GO:0007191IDA-adenylate cyclase-activating dopamine receptor signaling pathway2144334
GO:0007416ISS-synapse assembly-
GO:0007612IBA-learning-
GO:0007613IEA-memory-
GO:0007617ISS-mating behavior-
GO:0007625IEA-grooming behavior-
GO:0007628ISS-adult walking behavior-
GO:0008542ISS-visual learning-
GO:0010579IEA-positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway-
GO:0010628IMP-positive regulation of gene expression24136195
GO:0014002IEA-astrocyte development-
GO:0015872IEA-dopamine transport-
GO:0019226ISS-transmission of nerve impulse-
GO:0019228IEA-neuronal action potential-
GO:0021542IEA-dentate gyrus development-
GO:0021756IEA-striatum development-
GO:0021853ISS-cerebral cortex GABAergic interneuron migration-
GO:0030335ISS-positive regulation of cell migration-
GO:0030432IEA-peristalsis-
GO:0030819IDA-positive regulation of cAMP biosynthetic process1282671
GO:0035106IEA-operant conditioning-
GO:0042053IEA-regulation of dopamine metabolic process-
GO:0042311IEA-vasodilation-
GO:0042417IC-dopamine metabolic process8301582
GO:0042493ISS-response to drug-
GO:0042711IEA-maternal behavior-
GO:0043268ISS-positive regulation of potassium ion transport-
GO:0046323IEA-glucose import-
GO:0046959IEA-habituation-
GO:0046960IEA-sensitization-
GO:0048148IEA-behavioral response to cocaine-
GO:0051281IDA-positive regulation of release of sequestered calcium ion into cytosol1282671
GO:0051482IDA-positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway1282671
GO:0051584IC-regulation of dopamine uptake involved in synaptic transmission8301582
GO:0051968ISS-positive regulation of synaptic transmission, glutamatergic-
GO:0060134ISS-prepulse inhibition-
GO:0060158IDA-phospholipase C-activating dopamine receptor signaling pathway1282671
GO:0060158IGI-phospholipase C-activating dopamine receptor signaling pathway17194762
GO:0060291IEA-long-term synaptic potentiation-
GO:0060292IEA-long term synaptic depression-
GO:0071870IDA-cellular response to catecholamine stimulus18403039
GO:1903351IMP-cellular response to dopamine24136195
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DRD1ADA10661412150791 Co-localization
DRD1ADA10814612150791 Co-localization
DRD1ADORA110664610890919 Affinity Capture-Western
DRD1ADORA110814610890919 Affinity Capture-Western
DNAJC14DRD112451511331877 Reconstituted Complex; Two-hybrid
DNAJC14DRD110814611331877 Reconstituted Complex; Two-hybrid
COPGDRD111649611893085 Affinity Capture-Western; Reconstituted Complex
COPGDRD110814611893085 Affinity Capture-Western; Reconstituted Complex
COPG2DRD111792611893085 Affinity Capture-Western; Reconstituted Complex
COPG2DRD110814611893085 Affinity Capture-Western; Reconstituted Complex
HRH3DRD111641619413572 FRET
HRH3DRD110814619413572 FRET
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
DRD1DRD1_-48A/G, rs155417, rs1799914, rs4532 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
DRD1DRD1_2bpSTR, DRD1_4bpSTR, DRD1_EcoRI, rs10063995, rs11746641, rs11749676, rs12518222, rs13306309, rs155417, rs2168631, rs251937, rs265967, rs265981, rs267416, rs267418, rs35916350, rs4532, rs4867798, rs5326, rs5330, rs5331, rs686, rs6882300 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:99578
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070524-2'