Gene Symbol:	DRD2 ( D2DR,D2R )
Gene Full Name:	dopamine receptor D2
Band:	11q23.2
Quick Links	Entrez ID:1813; OMIM: 126450; Uniprot ID:DRD2_HUMAN; ENSEMBL ID: ENSG00000149295; HGNC ID: 3023
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0001669	IEA	-	acrosomal vesicle	-
GO:0005886	IDA	-	plasma membrane	26554819
GO:0005886	TAS	-	plasma membrane	-
GO:0005887	IDA	-	integral component of plasma membrane	8413587
GO:0014069	IEA	-	postsynaptic density	-
GO:0016328	IEA	-	lateral plasma membrane	-
GO:0030139	IEA	-	endocytic vesicle	-
GO:0030424	ISS	-	axon	-
GO:0030425	ISS	-	dendrite	-
GO:0030672	IBA	-	synaptic vesicle membrane	-
GO:0036126	IEA	-	sperm flagellum	-
GO:0043197	IEA	-	dendritic spine	-
GO:0043204	IEA	-	perikaryon	-
GO:0043679	IEA	-	axon terminus	-
GO:0060170	IDA	-	ciliary membrane	20531939
GO:0097730	IDA	-	non-motile cilium	20531939

GO ID	Evidence	Qualifier	GO_term	References
GO:0001591	IDA	-	dopamine neurotransmitter receptor activity, coupled via Gi/Go	8301582
GO:0004935	IBA	NOT	adrenergic receptor activity	-
GO:0005515	IPI	-	protein binding	10692483
GO:0008144	IDA	-	drug binding	8413587
GO:0035240	IBA	-	dopamine binding	-
GO:0035255	IEA	-	ionotropic glutamate receptor binding	-
GO:0042802	IPI	-	identical protein binding	18668123
GO:0042803	IEA	-	protein homodimerization activity	-
GO:0046982	IEA	-	protein heterodimerization activity	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0001659	ISS	-	temperature homeostasis	-
GO:0001666	IEA	-	response to hypoxia	-
GO:0001963	IBA	-	synaptic transmission, dopaminergic	-
GO:0001975	ISS	-	response to amphetamine	-
GO:0001976	ISS	-	neurological system process involved in regulation of systemic arterial blood pressure	-
GO:0002027	ISS	-	regulation of heart rate	-
GO:0002028	ISS	-	regulation of sodium ion transport	-
GO:0002031	IEA	-	G-protein coupled receptor internalization	-
GO:0002052	ISS	-	positive regulation of neuroblast proliferation	-
GO:0002092	IEA	-	positive regulation of receptor internalization	-
GO:0007194	IBA	-	negative regulation of adenylate cyclase activity	-
GO:0007195	IDA	-	adenylate cyclase-inhibiting dopamine receptor signaling pathway	26554819
GO:0007270	ISS	-	neuron-neuron synaptic transmission	-
GO:0007409	ISS	-	axonogenesis	-
GO:0007416	ISS	-	synapse assembly	-
GO:0007608	ISS	-	sensory perception of smell	-
GO:0007616	IEA	-	long-term memory	-
GO:0007625	IEA	-	grooming behavior	-
GO:0007626	ISS	-	locomotory behavior	-
GO:0007628	ISS	-	adult walking behavior	-
GO:0007631	IEA	-	feeding behavior	-
GO:0008104	ISS	-	protein localization	-
GO:0008285	ISS	-	negative regulation of cell proliferation	-
GO:0008306	ISS	-	associative learning	-
GO:0008542	ISS	-	visual learning	-
GO:0009416	ISS	-	response to light stimulus	-
GO:0009636	IBA	-	response to toxic substance	-
GO:0010039	IEA	-	response to iron ion	-
GO:0014059	IBA	-	regulation of dopamine secretion	-
GO:0014854	IEA	-	response to inactivity	-
GO:0016055	IEA	-	Wnt signaling pathway	-
GO:0021756	IEA	-	striatum development	-
GO:0021769	IEA	-	orbitofrontal cortex development	-
GO:0021853	ISS	-	cerebral cortex GABAergic interneuron migration	-
GO:0021984	ISS	-	adenohypophysis development	-
GO:0030336	ISS	-	negative regulation of cell migration	-
GO:0030432	ISS	-	peristalsis	-
GO:0030814	IDA	-	regulation of cAMP metabolic process	8666994
GO:0031223	IEA	-	auditory behavior	-
GO:0032147	IEA	-	activation of protein kinase activity	-
GO:0032228	ISS	-	regulation of synaptic transmission, GABAergic	-
GO:0032467	IMP	-	positive regulation of cytokinesis	22888021
GO:0032922	ISS	-	circadian regulation of gene expression	-
GO:0033602	IEA	-	negative regulation of dopamine secretion	-
GO:0034776	IDA	-	response to histamine	16839358
GO:0035094	IEA	-	response to nicotine	-
GO:0035810	IEA	-	positive regulation of urine volume	-
GO:0035815	IEA	-	positive regulation of renal sodium excretion	-
GO:0040018	IEA	-	positive regulation of multicellular organism growth	-
GO:0042220	ISS	-	response to cocaine	-
GO:0042321	IEA	-	negative regulation of circadian sleep/wake cycle, sleep	-
GO:0042417	IC	-	dopamine metabolic process	8301582
GO:0042493	IBA	-	response to drug	-
GO:0042493	ISS	-	response to drug	-
GO:0043266	IBA	-	regulation of potassium ion transport	-
GO:0043266	ISS	-	regulation of potassium ion transport	-
GO:0043278	ISS	-	response to morphine	-
GO:0043473	IEA	-	pigmentation	-
GO:0043666	IEA	-	regulation of phosphoprotein phosphatase activity	-
GO:0045745	IEA	-	positive regulation of G-protein coupled receptor protein signaling pathway	-
GO:0045776	ISS	-	negative regulation of blood pressure	-
GO:0045824	IEA	-	negative regulation of innate immune response	-
GO:0045944	IEA	-	positive regulation of transcription from RNA polymerase II promoter	-
GO:0046488	ISS	-	phosphatidylinositol metabolic process	-
GO:0046676	IEA	-	negative regulation of insulin secretion	-
GO:0048148	IBA	-	behavioral response to cocaine	-
GO:0048148	ISS	-	behavioral response to cocaine	-
GO:0048149	IBA	-	behavioral response to ethanol	-
GO:0048149	ISS	-	behavioral response to ethanol	-
GO:0048169	ISS	-	regulation of long-term neuronal synaptic plasticity	-
GO:0048678	IEA	-	response to axon injury	-
GO:0048755	ISS	-	branching morphogenesis of a nerve	-
GO:0050482	IDA	-	arachidonic acid secretion	8301582
GO:0050709	IDA	-	negative regulation of protein secretion	16839358
GO:0051209	ISS	-	release of sequestered calcium ion into cytosol	-
GO:0051481	IBA	-	negative regulation of cytosolic calcium ion concentration	-
GO:0051584	IC	-	regulation of dopamine uptake involved in synaptic transmission	8301582
GO:0051586	ISS	-	positive regulation of dopamine uptake involved in synaptic transmission	-
GO:0051823	IEA	-	regulation of synapse structural plasticity	-
GO:0051898	ISS	-	negative regulation of protein kinase B signaling	-
GO:0051898	NAS	-	negative regulation of protein kinase B signaling	21711983
GO:0051967	IBA	-	negative regulation of synaptic transmission, glutamatergic	-
GO:0051967	ISS	-	negative regulation of synaptic transmission, glutamatergic	-
GO:0060124	ISS	-	positive regulation of growth hormone secretion	-
GO:0060134	ISS	-	prepulse inhibition	-
GO:0060158	IGI	-	phospholipase C-activating dopamine receptor signaling pathway	17194762
GO:0060160	ISS	-	negative regulation of dopamine receptor signaling pathway	-
GO:0070374	IEA	-	positive regulation of ERK1 and ERK2 cascade	-
GO:0071880	IBA	NOT	adenylate cyclase-activating adrenergic receptor signaling pathway	-
GO:0090325	IEA	-	regulation of locomotion involved in locomotory behavior	-
GO:0099565	NAS	-	chemical synaptic transmission, postsynaptic	21711983
GO:1900168	IDA	-	positive regulation of glial cell-derived neurotrophic factor secretion	23373701
GO:1900273	IEA	-	positive regulation of long-term synaptic potentiation	-
GO:1901386	IBA	-	negative regulation of voltage-gated calcium channel activity	-

Gene Symbol	Interactant	Interaction ID	References	Description
DRD2	ADORA2A	106647	12804599	Affinity Capture-Western; FRET
DRD2	ADORA2A	108147	12804599	Affinity Capture-Western; FRET
PPP1R9B	DRD2	124202	10391935	Reconstituted Complex; Two-hybrid
PPP1R9B	DRD2	108147	10391935	Reconstituted Complex; Two-hybrid
FLNA	DRD2	108605	12181426	Affinity Capture-Western
FLNA	DRD2	108147	12181426	Affinity Capture-Western
EPB41L1	DRD2	108350	12181426	Reconstituted Complex; Two-hybrid
EPB41L1	DRD2	108147	12181426	Reconstituted Complex; Two-hybrid
KCNJ3	DRD2	109962	12297500	Affinity Capture-Western
KCNJ3	DRD2	108147	12297500	Affinity Capture-Western
KCNJ5	DRD2	109964	12297500	Affinity Capture-Western
KCNJ5	DRD2	108147	12297500	Affinity Capture-Western
KCNJ6	DRD2	109965	12297500	Affinity Capture-Western
KCNJ6	DRD2	108147	12297500	Affinity Capture-Western
NCS1	DRD2	116985	12351722	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCS1	DRD2	108147	12351722	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
CLIC6	DRD2	119900	14499480	Two-hybrid
CLIC6	DRD2	108147	14499480	Two-hybrid

AutismKB 2.0

Annotation Details for DRD2