AutismKB 2.0

Annotation Details for DRD3


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Basic Information Top
Gene Symbol:DRD3 ( D3DR,ETM1,FET1,MGC149204,MGC149205 )
Gene Full Name: dopamine receptor D3
Band: 3q13.31
Quick LinksEntrez ID:1814; OMIM: 126451; Uniprot ID:DRD3_HUMAN; ENSEMBL ID: ENSG00000151577; HGNC ID: 3024
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane16386234
GO:0005886TAS-plasma membrane-
GO:0005887IC-integral component of plasma membrane8301582
GO:0005887IDA-integral component of plasma membrane8413587
GO:0030139IEA-endocytic vesicle-
GO:0042995IEA-cell projection-
GO:0045177IEA-apical part of cell-
GO ID Evidence Qualifier GO_term References
GO:0001591IDA-dopamine neurotransmitter receptor activity, coupled via Gi/Go8301582
GO:0001591ISS-dopamine neurotransmitter receptor activity, coupled via Gi/Go-
GO:0005515IPI-protein binding10692483
GO:0008144IDA-drug binding8413587
GO:0008144ISS-drug binding-
GO:0019904IEA-protein domain specific binding-
GO:0031748IEA-D1 dopamine receptor binding-
GO:0035240IEA-dopamine binding-
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0001963IEA-synaptic transmission, dopaminergic-
GO:0001975IEA-response to amphetamine-
GO:0002016IEA-regulation of blood volume by renin-angiotensin-
GO:0002031IDA-G-protein coupled receptor internalization18424554
GO:0006874IDA-cellular calcium ion homeostasis7911712
GO:0007186IDA-G-protein coupled receptor signaling pathway7911712
GO:0007191IDA-adenylate cyclase-activating dopamine receptor signaling pathway18424554
GO:0007194IDA-negative regulation of adenylate cyclase activity7907363
GO:0007195IDA-adenylate cyclase-inhibiting dopamine receptor signaling pathway7907363
GO:0007611NAS-learning or memory14681904
GO:0007612NAS-learning15998189
GO:0007626ISS-locomotory behavior-
GO:0008284IEA-positive regulation of cell proliferation-
GO:0008542ISS-visual learning-
GO:0014059ISS-regulation of dopamine secretion-
GO:0019216IEA-regulation of lipid metabolic process-
GO:0030814IDA-regulation of cAMP metabolic process8666994
GO:0032416IEA-negative regulation of sodium:proton antiporter activity-
GO:0032467IMP-positive regulation of cytokinesis22888021
GO:0032922ISS-circadian regulation of gene expression-
GO:0034776IDA-response to histamine16839358
GO:0035176NAS-social behavior12860355
GO:0035483IEA-gastric emptying-
GO:0035815IEA-positive regulation of renal sodium excretion-
GO:0040014IEA-regulation of multicellular organism growth-
GO:0042220IEP-response to cocaine10415668
GO:0042417IC-dopamine metabolic process8301582
GO:0042493ISS-response to drug-
GO:0043278ISS-response to morphine-
GO:0045187IEA-regulation of circadian sleep/wake cycle, sleep-
GO:0045471ISSNOTresponse to ethanol-
GO:0045776ISS-negative regulation of blood pressure-
GO:0045840ISS-positive regulation of mitotic nuclear division-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0046717ISS-acid secretion-
GO:0048148IEP-behavioral response to cocaine8815892
GO:0048148ISS-behavioral response to cocaine-
GO:0048715ISS-negative regulation of oligodendrocyte differentiation-
GO:0050482IDA-arachidonic acid secretion8301582
GO:0050709IDA-negative regulation of protein secretion16839358
GO:0050883ISS-musculoskeletal movement, spinal reflex action-
GO:0051584IC-regulation of dopamine uptake involved in synaptic transmission8301582
GO:0051898ISS-negative regulation of protein kinase B signaling-
GO:0060134IMP-prepulse inhibition18325483
GO:0060160IEA-negative regulation of dopamine receptor signaling pathway-
GO:0060161ISS-positive regulation of dopamine receptor signaling pathway-
GO:0090325IEA-regulation of locomotion involved in locomotory behavior-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRB2DRD310814811384839 Reconstituted Complex
GRB2DRD310914211384839 Reconstituted Complex
FLNADRD310860511911837 Two-hybrid
FLNADRD310814811911837 Two-hybrid
EPB41L1DRD310835012181426 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EPB41L1DRD310814812181426 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
NCS1DRD310814812351722 Affinity Capture-Western
NCS1DRD311698512351722 Affinity Capture-Western
CLIC6DRD311990014499480 Reconstituted Complex; Two-hybrid
CLIC6DRD310814814499480 Reconstituted Complex; Two-hybrid
GIPC1DRD311597814499480 Two-hybrid
GIPC1DRD310814814499480 Two-hybrid
RDXDRD311189414499480 Two-hybrid
RDXDRD310814814499480 Two-hybrid
MPDZDRD310814814499480 Two-hybrid
MPDZDRD311430714499480 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
DRD3rs6280 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
DRD3DRD3_3'-STR, rs1503670, rs2134655, rs324026, rs4646996, rs6280, rs905568, rs963468 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
DRD3D3S1310, D3S1610, DRD3_2249G/A, DRD3_4147C/T, DRD3_5bp-Indel, DRD3_6733G/A, DRD3_7685G/C, DRD3_Ala38Thr, DRD3_PvuII, DRD3_g.-6664T>G, MT_4*, rs1025398, rs10934251, rs10934254, rs10934256, rs11706283, rs12636133, rs13061336, rs1354348, rs1394016, rs1486009, rs1486012, rs1503670, rs167770, rs167771, rs16822416, rs16822440, rs17605608, rs1800827, rs1800828, rs2046496, rs2087017, rs2134655, rs226082, rs2399496, rs2399504, rs2630349, rs2630350, rs324026, rs324029, rs324030, rs3732783, rs3732790, rs3732791, rs3773678, rs3773679, rs4646996, rs4682148, rs6280, rs6808291, rs7611535, rs7616367, rs7620754, rs7625282, rs762582, rs7631540, rs7633291, rs7638876, rs905568, rs9283560, rs9288990, rs963468, rs9813633, rs9817063, rs9824856, rs9825563, rs9868039, rs9880168 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:94925
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-021119-1'