AutismKB 2.0

Annotation Details for DRD4


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Basic Information Top
Gene Symbol:DRD4 ( D4DR )
Gene Full Name: dopamine receptor D4
Band: 11p15.5
Quick LinksEntrez ID:1815; OMIM: 126452; Uniprot ID:DRD4_HUMAN; ENSEMBL ID: ENSG00000069696; HGNC ID: 3025
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005886IDA-plasma membrane20531939
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane8413587
GO:0016020IDA-membrane7512953
GO:0098794IEA-postsynapse-
GO ID Evidence Qualifier GO_term References
GO:0001591IDA-dopamine neurotransmitter receptor activity, coupled via Gi/Go1840645
GO:0001591ISS-dopamine neurotransmitter receptor activity, coupled via Gi/Go-
GO:0004952IDA-dopamine neurotransmitter receptor activity8413587
GO:0005515IPI-protein binding12297500
GO:0008144IDA-drug binding1319557
GO:0015459NAS-potassium channel regulator activity12297500
GO:0017124IDA-SH3 domain binding9843378
GO:0035240IDA-dopamine binding1319557
GO:0042802IPI-identical protein binding21184734
GO ID Evidence Qualifier GO_term References
GO:0000187IDA-activation of MAPK activity9843378
GO:0001662NAS-behavioral fear response12860355
GO:0001975ISS-response to amphetamine-
GO:0006874IC-cellular calcium ion homeostasis7921596
GO:0007194IDA-negative regulation of adenylate cyclase activity7512953
GO:0007195IDA-adenylate cyclase-inhibiting dopamine receptor signaling pathway7512953
GO:0007212IDA-dopamine receptor signaling pathway1840645
GO:0008344ISS-adult locomotory behavior-
GO:0030818IDA-negative regulation of cAMP biosynthetic process7512953
GO:0032417IDA-positive regulation of sodium:proton antiporter activity7512953
GO:0033674IDA-positive regulation of kinase activity15755724
GO:0034776IDA-response to histamine16839358
GO:0035176NAS-social behavior11126393
GO:0042053ISS-regulation of dopamine metabolic process-
GO:0042417IC-dopamine metabolic process1840645
GO:0042596ISS-fear response-
GO:0042752ISS-regulation of circadian rhythm-
GO:0048148ISS-behavioral response to cocaine-
GO:0048149TAS-behavioral response to ethanol12888781
GO:0048511IEA-rhythmic process-
GO:0050482IDA-arachidonic acid secretion7512953
GO:0050709IDA-negative regulation of protein secretion16839358
GO:0051586IC-positive regulation of dopamine uptake involved in synaptic transmission1840645
GO:0060080ISS-inhibitory postsynaptic potential-
GO:1901386IDA-negative regulation of voltage-gated calcium channel activity7921596
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
GRB2DRD41081499843378 Reconstituted Complex
GRB2DRD41091429843378 Reconstituted Complex
NCK1DRD41107709843378 Reconstituted Complex
NCK1DRD41081499843378 Reconstituted Complex
KCNJ3DRD410996212297500 Affinity Capture-Western
KCNJ3DRD410814912297500 Affinity Capture-Western
KCNJ5DRD410996412297500 Affinity Capture-Western
KCNJ5DRD410814912297500 Affinity Capture-Western
KCNJ9DRD410996712297500 Affinity Capture-Western
KCNJ9DRD410814912297500 Affinity Capture-Western
CLIC6DRD411990014499480 Two-hybrid
CLIC6DRD410814914499480 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
DRD4DRD4_exon3 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
DRD4DRD4_48bpVNTR(Ex3), rs1800955, rs4646984 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
DRD4DRD4_11C/T, DRD4_48bpVNTR, DRD4_Gly11Arg, DRD4_HincII, DRD4_PstI, DRD4_SmaI, rs10902180, rs11246224, rs11246226, rs12720364, rs1800443, rs1800955, rs2396543, rs3758653, rs3842250, rs41298422, rs4331145, rs4646983, rs4646984, rs4987058, rs71695878, rs747302, rs747303, rs916455, rs916457, rs936460, rs936461, rs936465 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:94926
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070112-996'