AutismKB 2.0

Annotation Details for DUSP3


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Basic Information Top
Gene Symbol:DUSP3 ( VHR )
Gene Full Name: dual specificity phosphatase 3
Band: 17q21.31
Quick LinksEntrez ID:1845; OMIM: 600183; Uniprot ID:DUS3_HUMAN; ENSEMBL ID: ENSG00000108861; HGNC ID: 3069
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001772IDA-immunological synapse12447358
GO:0005634IDA-nucleus16604064
GO:0005654IDA-nucleoplasm-
GO:0005654TAS-nucleoplasm-
GO:0005829IDA-cytosol12447358
GO:0070062IDA-extracellular exosome23376485
GO ID Evidence Qualifier GO_term References
GO:0004725IDA-protein tyrosine phosphatase activity11863439
GO:0004725TAS-protein tyrosine phosphatase activity-
GO:0008138IDA-protein tyrosine/serine/threonine phosphatase activity7876121
GO:0008138IMP-protein tyrosine/serine/threonine phosphatase activity7961745
GO:0016791IDA-phosphatase activity24531476
GO:0019901IDA-protein kinase binding22572157
GO:0033549IMP-MAP kinase phosphatase activity16604064
GO ID Evidence Qualifier GO_term References
GO:0000188IMP-inactivation of MAPK activity16604064
GO:0001701IEA-in utero embryonic development-
GO:0016311IDA-dephosphorylation24531476
GO:0035335IDA-peptidyl-tyrosine dephosphorylation7876121
GO:0043409IMP-negative regulation of MAPK cascade16604064
GO:0045931IMP-positive regulation of mitotic cell cycle16604064
GO:0046329IDA-negative regulation of JNK cascade11085983
GO:0046329IMP-negative regulation of JNK cascade19010898
GO:0050860IDA-negative regulation of T cell receptor signaling pathway12447358
GO:0050868IDA-negative regulation of T cell activation12447358
GO:0070373IDA-negative regulation of ERK1 and ERK2 cascade11085983
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EGFRDUSP31081781281549 Biochemical Activity
EGFRDUSP31082761281549 Biochemical Activity
MAPK1DUSP310817810224087 Affinity Capture-Western; Biochemical Activity
MAPK1DUSP311158010224087 Affinity Capture-Western; Biochemical Activity
MAPK3DUSP310817810224087 Affinity Capture-Western; Biochemical Activity
MAPK3DUSP311158110224087 Affinity Capture-Western; Biochemical Activity
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1919599
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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