AutismKB 2.0

Annotation Details for DUSP6


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Basic Information Top
Gene Symbol:DUSP6 ( MKP3,PYST1 )
Gene Full Name: dual specificity phosphatase 6
Band: 12q21.33
Quick LinksEntrez ID:1848; OMIM: 602748; Uniprot ID:DUS6_HUMAN; ENSEMBL ID: ENSG00000139318; HGNC ID: 3072
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm8670865
GO:0005829TAS-cytosol-
GO ID Evidence Qualifier GO_term References
GO:0004725TAS-protein tyrosine phosphatase activity-
GO:0008138TAS-protein tyrosine/serine/threonine phosphatase activity-
GO:0017017IDA-MAP kinase tyrosine/serine/threonine phosphatase activity8670865
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000187TAS-activation of MAPK activity-
GO:0000188IDA-inactivation of MAPK activity8670865
GO:0009953IBA-dorsal/ventral pattern formation-
GO:0014070IEA-response to organic cyclic compound-
GO:0030154IEA-cell differentiation-
GO:0035335IDA-peptidyl-tyrosine dephosphorylation8670865
GO:0040036IBA-regulation of fibroblast growth factor receptor signaling pathway-
GO:0042493IEA-response to drug-
GO:0042663IBA-regulation of endodermal cell fate specification-
GO:0043065IDA-positive regulation of apoptotic process10846176
GO:0051409IEP-response to nitrosative stress10846176
GO:0060420IBA-regulation of heart growth-
GO:0070373IMP-negative regulation of ERK1 and ERK2 cascade18771677
GO:0070848IEA-response to growth factor-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DUSP6MAPK1410818111359773 Affinity Capture-Western
DUSP6MAPK1410781911359773 Affinity Capture-Western
MAPK3DUSP61081819535927 Affinity Capture-Western; Reconstituted Complex
MAPK3DUSP61115819535927 Affinity Capture-Western; Reconstituted Complex
MAPK1DUSP61081819535927 Reconstituted Complex
MAPK1DUSP61115809535927 Reconstituted Complex
MDFIDUSP610818116189514 Two-hybrid
MDFIDUSP611035316189514 Two-hybrid
TEX11DUSP610818116189514 Two-hybrid
TEX11DUSP612109316189514 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
DUSP6rs2279574 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:1914853
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030613-1'