AutismKB 2.0

Annotation Details for AGTR1


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Basic Information Top
Gene Symbol:AGTR1 ( AG2S,AGTR1A,AGTR1B,AT1,AT1B,AT1R,AT2R1,AT2R1A,AT2R1B,HAT1R )
Gene Full Name: angiotensin II receptor, type 1
Band: 3q24
Quick LinksEntrez ID:185; OMIM: 106165; Uniprot ID:AGTR1_HUMAN; ENSEMBL ID: ENSG00000144891; HGNC ID: 336
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005622IEA-intracellular-
GO:0005886IDA-plasma membrane19023134
GO:0005886TAS-plasma membrane-
GO:0005887IC-integral component of plasma membrane1378723
GO:0016021NAS-integral component of membrane8135787
GO ID Evidence Qualifier GO_term References
GO:0001596IDA-angiotensin type I receptor activity10993080
GO:0001596IPI-angiotensin type I receptor activity1378723
GO:0004945IDA-angiotensin type II receptor activity1567413
GO:0005515IPI-protein binding1378723
GO:0031711IPI-bradykinin receptor binding10993080
GO:0046982IPI-protein heterodimerization activity10993080
GO ID Evidence Qualifier GO_term References
GO:0001558NAS-regulation of cell growth17159080
GO:0001822IMP-kidney development16116425
GO:0002018NAS-renin-angiotensin regulation of aldosterone production17159080
GO:0002034IC-regulation of blood vessel diameter by renin-angiotensin10993080
GO:0003081IC-regulation of systemic arterial blood pressure by renin-angiotensin1378723
GO:0007186IDA-G-protein coupled receptor signaling pathway1378723
GO:0007200NAS-phospholipase C-activating G-protein coupled receptor signaling pathway17159080
GO:0007204IDA-positive regulation of cytosolic calcium ion concentration1567413
GO:0007266IDA-Rho protein signal transduction15611106
GO:0010744IC-positive regulation of macrophage derived foam cell differentiation18971559
GO:0010873IMP-positive regulation of cholesterol esterification18971559
GO:0019229IC-regulation of vasoconstriction1378723
GO:0019229IDA-regulation of vasoconstriction15117835
GO:0019229NAS-regulation of vasoconstriction17159080
GO:0019722IDA-calcium-mediated signaling1567413
GO:0032270IMP-positive regulation of cellular protein metabolic process18971559
GO:0032430IMP-positive regulation of phospholipase A2 activity17069818
GO:0033864TAS-positive regulation of NAD(P)H oxidase activity17159080
GO:0034374NAS-low-density lipoprotein particle remodeling17069818
GO:0035813NAS-regulation of renal sodium excretion17159080
GO:0038166IDA-angiotensin-activated signaling pathway1567413
GO:0042127NAS-regulation of cell proliferation17159080
GO:0050727IC-regulation of inflammatory response1378723
GO:0050729TAS-positive regulation of inflammatory response17159080
GO:0051482IDA-positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway1567413
GO:0060326IDA-cell chemotaxis15635042
GO:0086097IDA-phospholipase C-activating angiotensin-activated signaling pathway1378723
GO:0097746IC-regulation of blood vessel diameter1378723
GO:2000379TAS-positive regulation of reactive oxygen species metabolic process17159080
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
AGTR1ADRBK11066919211925 Affinity Capture-Western
AGTR1ADRBK11066659211925 Affinity Capture-Western
GRK5AGTR11066919211925 Affinity Capture-Western
GRK5AGTR11091279211925 Affinity Capture-Western
BDKRB2AGTR110669110993080 Co-fractionation
BDKRB2AGTR110709310993080 Co-fractionation
RAB5AAGTR110669111682489 Reconstituted Complex
RAB5AAGTR111180611682489 Reconstituted Complex
AGTRAPAGTR110669111733189 Reconstituted Complex
AGTRAPAGTR112135611733189 Reconstituted Complex
ZBTB16AGTR110669114657020 Reconstituted Complex; Two-hybrid
ZBTB16AGTR111349814657020 Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:87964
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070912-546'