AutismKB 2.0

Annotation Details for DYRK1A


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Basic Information Top
Gene Symbol:DYRK1A ( DYRK,DYRK1,HP86,MNB,MNBH )
Gene Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Band: 21q22.13
Quick LinksEntrez ID:1859; OMIM: 600855; Uniprot ID:DYR1A_HUMAN; ENSEMBL ID: ENSG00000157540; HGNC ID: 3091
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus23415227
GO:0005634ISS-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0016607ISS-nuclear speck-
GO:0030529IEA-intracellular ribonucleoprotein complex-
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity-
GO:0004674ISS-protein serine/threonine kinase activity20736167
GO:0004712IEA-protein serine/threonine/tyrosine kinase activity-
GO:0004713ISS-protein tyrosine kinase activity-
GO:0004715IDA-non-membrane spanning protein tyrosine kinase activity9748265
GO:0005515IPI-protein binding14500717
GO:0005524IEA-ATP binding-
GO:0042802IEA-identical protein binding-
GO:0043621ISS-protein self-association-
GO:0048156ISS-tau protein binding20736167
GO ID Evidence Qualifier GO_term References
GO:0000381IEA-regulation of alternative mRNA splicing, via spliceosome-
GO:0006468ISS-protein phosphorylation-
GO:0007399TAS-nervous system development8769099
GO:0007623ISS-circadian rhythm-
GO:0016032IEA-viral process-
GO:0018105IEA-peptidyl-serine phosphorylation-
GO:0018107ISS-peptidyl-threonine phosphorylation20736167
GO:0018108IDA-peptidyl-tyrosine phosphorylation9748265
GO:0018108ISS-peptidyl-tyrosine phosphorylation-
GO:0043518ISS-negative regulation of DNA damage response, signal transduction by p53 class mediator20736167
GO:0046777ISS-protein autophosphorylation-
GO:0048025IEA-negative regulation of mRNA splicing, via spliceosome-
GO:0090312ISS-positive regulation of protein deacetylation20736167
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
DYRK1ADNM110809911877424 Reconstituted Complex
DYRK1ADNM110819211877424 Reconstituted Complex
HIST1H2BBDYRK1A10819210644696 Biochemical Activity
HIST1H2BBDYRK1A10927110644696 Biochemical Activity
HIST1H3ADYRK1A11394610644696 Biochemical Activity
HIST1H3ADYRK1A10819210644696 Biochemical Activity
HIST1H4ADYRK1A10819210644696 Biochemical Activity
HIST1H4ADYRK1A11395510644696 Biochemical Activity
DCAF7DYRK1A11553214593110 Affinity Capture-Western; Co-purification
DCAF7DYRK1A10819214593110 Affinity Capture-Western; Co-purification
CLASRPDYRK1A11630214623875 Biochemical Activity
CLASRPDYRK1A10819214623875 Biochemical Activity
SRSF1DYRK1A10819214623875 Biochemical Activity
SRSF1DYRK1A11232414623875 Biochemical Activity
SRSF4DYRK1A11232714623875 Biochemical Activity
SRSF4DYRK1A10819214623875 Biochemical Activity
SRSF5DYRK1A11232814623875 Biochemical Activity
SRSF5DYRK1A10819214623875 Biochemical Activity
CCNL2DYRK1A10819214623875 Biochemical Activity
CCNL2DYRK1A12356614623875 Biochemical Activity
SFNDYRK1A10907215778465 Affinity Capture-MS
SFNDYRK1A10819215778465 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
DYRK1Ars1137600, rs11701483, rs11702623, rs2154545, rs2835740, rs2835761, rs2835762, rs8126696, rs8132976 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1330299
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050302-29'