Gene Symbol:	DYRK1A ( DYRK,DYRK1,HP86,MNB,MNBH )
Gene Full Name:	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
Band:	21q22.13
Quick Links	Entrez ID:1859; OMIM: 600855; Uniprot ID:DYR1A_HUMAN; ENSEMBL ID: ENSG00000157540; HGNC ID: 3091
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0005634	IDA	-	nucleus	23415227
GO:0005634	ISS	-	nucleus	-
GO:0005654	TAS	-	nucleoplasm	-
GO:0016607	ISS	-	nuclear speck	-
GO:0030529	IEA	-	intracellular ribonucleoprotein complex	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0004672	TAS	-	protein kinase activity	-
GO:0004674	ISS	-	protein serine/threonine kinase activity	20736167
GO:0004712	IEA	-	protein serine/threonine/tyrosine kinase activity	-
GO:0004713	ISS	-	protein tyrosine kinase activity	-
GO:0004715	IDA	-	non-membrane spanning protein tyrosine kinase activity	9748265
GO:0005515	IPI	-	protein binding	14500717
GO:0005524	IEA	-	ATP binding	-
GO:0042802	IEA	-	identical protein binding	-
GO:0043621	ISS	-	protein self-association	-
GO:0048156	ISS	-	tau protein binding	20736167

GO ID	Evidence	Qualifier	GO_term	References
GO:0000381	IEA	-	regulation of alternative mRNA splicing, via spliceosome	-
GO:0006468	ISS	-	protein phosphorylation	-
GO:0007399	TAS	-	nervous system development	8769099
GO:0007623	ISS	-	circadian rhythm	-
GO:0016032	IEA	-	viral process	-
GO:0018105	IEA	-	peptidyl-serine phosphorylation	-
GO:0018107	ISS	-	peptidyl-threonine phosphorylation	20736167
GO:0018108	IDA	-	peptidyl-tyrosine phosphorylation	9748265
GO:0018108	ISS	-	peptidyl-tyrosine phosphorylation	-
GO:0043518	ISS	-	negative regulation of DNA damage response, signal transduction by p53 class mediator	20736167
GO:0046777	ISS	-	protein autophosphorylation	-
GO:0048025	IEA	-	negative regulation of mRNA splicing, via spliceosome	-
GO:0090312	ISS	-	positive regulation of protein deacetylation	20736167

Gene Symbol	Interactant	Interaction ID	References	Description
DYRK1A	DNM1	108099	11877424	Reconstituted Complex
DYRK1A	DNM1	108192	11877424	Reconstituted Complex
HIST1H2BB	DYRK1A	108192	10644696	Biochemical Activity
HIST1H2BB	DYRK1A	109271	10644696	Biochemical Activity
HIST1H3A	DYRK1A	113946	10644696	Biochemical Activity
HIST1H3A	DYRK1A	108192	10644696	Biochemical Activity
HIST1H4A	DYRK1A	108192	10644696	Biochemical Activity
HIST1H4A	DYRK1A	113955	10644696	Biochemical Activity
DCAF7	DYRK1A	115532	14593110	Affinity Capture-Western; Co-purification
DCAF7	DYRK1A	108192	14593110	Affinity Capture-Western; Co-purification
CLASRP	DYRK1A	116302	14623875	Biochemical Activity
CLASRP	DYRK1A	108192	14623875	Biochemical Activity
SRSF1	DYRK1A	108192	14623875	Biochemical Activity
SRSF1	DYRK1A	112324	14623875	Biochemical Activity
SRSF4	DYRK1A	112327	14623875	Biochemical Activity
SRSF4	DYRK1A	108192	14623875	Biochemical Activity
SRSF5	DYRK1A	112328	14623875	Biochemical Activity
SRSF5	DYRK1A	108192	14623875	Biochemical Activity
CCNL2	DYRK1A	108192	14623875	Biochemical Activity
CCNL2	DYRK1A	123566	14623875	Biochemical Activity
SFN	DYRK1A	109072	15778465	Affinity Capture-MS
SFN	DYRK1A	108192	15778465	Affinity Capture-MS

AutismKB 2.0

Annotation Details for DYRK1A