AutismKB 2.0

Annotation Details for AGTR2


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Basic Information Top
Gene Symbol:AGTR2 ( AT2,ATGR2,MRX88 )
Gene Full Name: angiotensin II receptor, type 2
Band: Xq23
Quick LinksEntrez ID:186; OMIM: 300034; Uniprot ID:AGTR2_HUMAN; ENSEMBL ID: ENSG00000180772; HGNC ID: 338
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005886TAS-plasma membrane-
GO:0005887IC-integral component of plasma membrane10406457
GO:0048471IEA-perinuclear region of cytoplasm-
GO ID Evidence Qualifier GO_term References
GO:0004945IPI-angiotensin type II receptor activity10406457
GO:0005515IPI-protein binding10406457
GO:0008134IEA-transcription factor binding-
GO:0017046IEA-peptide hormone binding-
GO:0048019TAS-receptor antagonist activity17159079
GO ID Evidence Qualifier GO_term References
GO:0001974TAS-blood vessel remodeling17159080
GO:0001991ISS-regulation of systemic arterial blood pressure by circulatory renin-angiotensin-
GO:0002018IEA-renin-angiotensin regulation of aldosterone production-
GO:0002033IEA-angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure-
GO:0002035IEA-brain renin-angiotensin system-
GO:0006883IEA-cellular sodium ion homeostasis-
GO:0006954IEA-inflammatory response-
GO:0007166IDA-cell surface receptor signaling pathway10406457
GO:0007186IC-G-protein coupled receptor signaling pathway10406457
GO:0007199ISS-G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger17000928
GO:0007263IC-nitric oxide mediated signal transduction17000928
GO:0007263TAS-nitric oxide mediated signal transduction17159080
GO:0007420NAS-brain development12089445
GO:0008217TAS-regulation of blood pressure7477266
GO:0008284IEA-positive regulation of cell proliferation-
GO:0010459ISS-negative regulation of heart rate-
GO:0010700IEA-negative regulation of norepinephrine secretion-
GO:0021695IEA-cerebellar cortex development-
GO:0030308TAS-negative regulation of cell growth17159080
GO:0032304IEA-negative regulation of icosanoid secretion-
GO:0032516IDA-positive regulation of phosphoprotein phosphatase activity10406457
GO:0035556ISS-intracellular signal transduction17000928
GO:0035566IEA-regulation of metanephros size-
GO:0035640IEA-exploration behavior-
GO:0035815IEA-positive regulation of renal sodium excretion-
GO:0035932IEA-aldosterone secretion-
GO:0038166IEA-angiotensin-activated signaling pathway-
GO:0042311IDA-vasodilation15117835
GO:0042416IEA-dopamine biosynthetic process-
GO:0042990IEA-regulation of transcription factor import into nucleus-
GO:0043537NAS-negative regulation of blood vessel endothelial cell migration15710780
GO:0045429IC-positive regulation of nitric oxide biosynthetic process17000928
GO:0045893IEA-positive regulation of transcription, DNA-templated-
GO:0048147IEA-negative regulation of fibroblast proliferation-
GO:0050715IEA-positive regulation of cytokine secretion-
GO:0051000ISS-positive regulation of nitric-oxide synthase activity17000928
GO:0051387IMP-negative regulation of neurotrophin TRK receptor signaling pathway10406457
GO:0061049IEA-cell growth involved in cardiac muscle cell development-
GO:0071549IEA-cellular response to dexamethasone stimulus-
GO:0072300IEA-positive regulation of metanephric glomerulus development-
GO:0090190IEA-positive regulation of branching involved in ureteric bud morphogenesis-
GO:1900116IEA-extracellular negative regulation of signal transduction-
GO:2001238IMP-positive regulation of extrinsic apoptotic signaling pathway10406457
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
AGTRAPAGTR210669211733189 Reconstituted Complex
AGTRAPAGTR212135611733189 Reconstituted Complex
MTUS1AGTR210669215123706 Affinity Capture-Western; Two-hybrid
MTUS1AGTR212157315123706 Affinity Capture-Western; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:87966
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050306-56'