AutismKB 2.0

Annotation Details for ECT2


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Basic Information Top
Gene Symbol:ECT2 ( ARHGEF31,FLJ10461,MGC138291 )
Gene Full Name: epithelial cell transforming sequence 2 oncogene
Band: 3q26.31
Quick LinksEntrez ID:1894; OMIM: 600586; Uniprot ID:ECT2_HUMAN; ENSEMBL ID: ENSG00000114346; HGNC ID: 3155
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus15254234
GO:0005737IDA-cytoplasm19617897
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0005911IDA-cell-cell junction15254234
GO:0005923IDA-bicellular tight junction15254234
GO:0030496IDA-midbody15545273
GO:0032154IDA-cleavage furrow16103226
GO:0072686IDA-mitotic spindle15254234
GO:0097149IDA-centralspindlin complex16236794
GO ID Evidence Qualifier GO_term References
GO:0004871IMP-signal transducer activity12761501
GO:0005085TAS-guanyl-nucleotide exchange factor activity-
GO:0005089IDA-Rho guanyl-nucleotide exchange factor activity12761501
GO:0005089TAS-Rho guanyl-nucleotide exchange factor activity-
GO:0005096IMP-GTPase activator activity15642749
GO:0005515IPI-protein binding15254234
GO:0017048IEA-Rho GTPase binding-
GO:0042803IDA-protein homodimerization activity15545273
GO ID Evidence Qualifier GO_term References
GO:0000902IEA-cell morphogenesis-
GO:0000910IMP-cytokinesis16236794
GO:0015031IEA-protein transport-
GO:0032147IDA-activation of protein kinase activity15254234
GO:0032467IDA-positive regulation of cytokinesis15545273
GO:0032467IMP-positive regulation of cytokinesis12761501
GO:0035023IEA-regulation of Rho protein signal transduction-
GO:0035556IEA-intracellular signal transduction-
GO:0042307ISS-positive regulation of protein import into nucleus-
GO:0043065IDA-positive regulation of apoptotic process21373644
GO:0043065TAS-positive regulation of apoptotic process-
GO:0043123IMP-positive regulation of I-kappaB kinase/NF-kappaB signaling12761501
GO:0043547IDA-positive regulation of GTPase activity17115030
GO:0043547IMP-positive regulation of GTPase activity21373644
GO:0045666ISS-positive regulation of neuron differentiation-
GO:0045859IDA-regulation of protein kinase activity15254234
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
GO:0051260IDA-protein homooligomerization15545273
GO:0051988IMP-regulation of attachment of spindle microtubules to kinetochore15642749
GO:0070301IDA-cellular response to hydrogen peroxide21373644
GO:0070830IMP-bicellular tight junction assembly15254234
GO:0071277IDA-cellular response to calcium ion15254234
GO:0071479IDA-cellular response to ionizing radiation21373644
GO:0090630IDA-activation of GTPase activity19617897
GO:0090630IMP-activation of GTPase activity19617897
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
KLHL20ECT210822314668487 Two-hybrid
KLHL20ECT211810014668487 Two-hybrid
PRKCZECT210822315254234 Affinity Capture-Western
PRKCZECT211157615254234 Affinity Capture-Western
PARD3ECT210822315254234 Affinity Capture-Western
PARD3ECT212113415254234 Affinity Capture-Western
PARD6AECT210822315254234 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
PARD6AECT211915715254234 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95281
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040831-2'