AutismKB 2.0

Annotation Details for ABCA1


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Basic Information Top
Gene Symbol:ABCA1 ( ABC-1,ABC1,CERP,FLJ14958,HDLDT1,MGC164864,MGC165011,TGD )
Gene Full Name: ATP-binding cassette, sub-family A (ABC1), member 1
Band: 9q31.1
Quick LinksEntrez ID:19; OMIM: 600046; Uniprot ID:ABCA1_HUMAN; ENSEMBL ID: ENSG00000165029; HGNC ID: 29
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005789TAS-endoplasmic reticulum membrane-
GO:0005794IEA-Golgi apparatus-
GO:0005886IDA-plasma membrane23931754
GO:0005886TAS-plasma membrane-
GO:0005887IDA-integral component of plasma membrane10525055
GO:0009897IEA-external side of plasma membrane-
GO:0030139IDA-endocytic vesicle14747463
GO:0034364IEA-high-density lipoprotein particle-
GO:0043231IBA-intracellular membrane-bounded organelle-
GO:0045121IDA-membrane raft15469992
GO:0045335IDA-phagocytic vesicle15469992
GO:0048471IDA-perinuclear region of cytoplasm23931754
GO ID Evidence Qualifier GO_term References
GO:0005102IPI-receptor binding23931754
GO:0005515IPI-protein binding12084722
GO:0005524IDA-ATP binding11700048
GO:0005543IC-phospholipid binding16702602
GO:0005548IDA-phospholipid transporter activity16702602
GO:0008509ISS-anion transmembrane transporter activity-
GO:0015485IC-cholesterol binding12084722
GO:0016887IDA-ATPase activity24097981
GO:0017127IDA-cholesterol transporter activity12084722
GO:0019905IPI-syntaxin binding15469992
GO:0031267IPI-small GTPase binding16443932
GO:0034185IPI-apolipoprotein binding11162594
GO:0034186IPI-apolipoprotein A-I binding11162594
GO:0034188IDA-apolipoprotein A-I receptor activity16443932
GO:0042626IBA-ATPase activity, coupled to transmembrane movement of substances-
GO:0051117IPI-ATPase binding23931754
GO:0090554IDA-phosphatidylcholine-translocating ATPase activity24097981
GO:0090556IDA-phosphatidylserine-translocating ATPase activity24097981
GO ID Evidence Qualifier GO_term References
GO:0006497IEA-protein lipidation-
GO:0006911IEA-phagocytosis, engulfment-
GO:0007040IDA-lysosome organization15163665
GO:0007186IMP-G-protein coupled receptor signaling pathway16443932
GO:0007584IEA-response to nutrient-
GO:0008203IDA-cholesterol metabolic process14747463
GO:0010745TAS-negative regulation of macrophage derived foam cell differentiation18490524
GO:0010875IMP-positive regulation of cholesterol efflux25084135
GO:0010887TAS-negative regulation of cholesterol storage18490524
GO:0015917IEA-aminophospholipid transport-
GO:0016197IDA-endosomal transport14747463
GO:0019216TAS-regulation of lipid metabolic process-
GO:0030819IMP-positive regulation of cAMP biosynthetic process14701824
GO:0032367IMP-intracellular cholesterol transport10431236
GO:0032489IMP-regulation of Cdc42 protein signal transduction16443932
GO:0033344IDA-cholesterol efflux10431236
GO:0033344IMP-cholesterol efflux16443932
GO:0033700IDA-phospholipid efflux10431236
GO:0033700IMP-phospholipid efflux16702602
GO:0034380IMP-high-density lipoprotein particle assembly10431236
GO:0034380TAS-high-density lipoprotein particle assembly-
GO:0034616IEP-response to laminar fluid shear stress15358760
GO:0038027IEA-apolipoprotein A-I-mediated signaling pathway-
GO:0042493IEA-response to drug-
GO:0042632IDA-cholesterol homeostasis10431236
GO:0042632TAS-cholesterol homeostasis24097981
GO:0043691IMP-reverse cholesterol transport10431236
GO:0045332IDA-phospholipid translocation24097981
GO:0050702IMP-interleukin-1 beta secretion11855831
GO:0055091IMP-phospholipid homeostasis16702602
GO:0055098IEP-response to low-density lipoprotein particle15358760
GO:0060155IMP-platelet dense granule organization15163665
GO:0071222IEA-cellular response to lipopolysaccharide-
GO:0071300IEA-cellular response to retinoic acid-
GO:0071397IEA-cellular response to cholesterol-
GO:0090107TAS-regulation of high-density lipoprotein particle assembly24097981
GO:0098656IEA-anion transmembrane transport-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
CREBBPABCA110653711864601 Affinity Capture-Western
CREBBPABCA110777711864601 Affinity Capture-Western
SNTB2ABCA111252812054535 Affinity Capture-Western; Two-hybrid
SNTB2ABCA110653712054535 Affinity Capture-Western; Two-hybrid
PRPF8ABCA111584212054535 Two-hybrid
PRPF8ABCA110653712054535 Two-hybrid
AOX1ABCA110681312054535 Two-hybrid
AOX1ABCA110653712054535 Two-hybrid
SDHBABCA111229112054535 Two-hybrid
SDHBABCA110653712054535 Two-hybrid
UGP1ABCA110653712054535 Two-hybrid
UGP1ABCA111320612054535 Two-hybrid
APOA1ABCA110653712084722 Reconstituted Complex
APOA1ABCA110683212084722 Reconstituted Complex
FADDABCA111430212235128 Reconstituted Complex; Two-hybrid
FADDABCA110653712235128 Reconstituted Complex; Two-hybrid
XPCABCA111334512505994 Reconstituted Complex; Two-hybrid
XPCABCA110653712505994 Reconstituted Complex; Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ABCA1hcv2741108, rs10120087, rs10820743, rs10991414, rs1175293, rs11789603, rs12350560, rs1800977, rs1883025, rs1929841, rs2020926, rs2020927, rs2043664, rs2065412, rs2066714, rs2066715, rs2066716, rs2066717, rs2066718, rs2066881, rs2230805, rs2230806, rs2230808, rs2243312, rs2246293, rs2254884, rs2274873, rs2297402, rs2297404, rs2297406, rs2297409, rs2422493, rs2437811, rs2472377, rs2472384, rs2472386, rs2472496, rs2482433, rs2487039, rs2487042, rs2487054, rs2515601, rs2575875, rs2575876, rs2575879, rs2740483, rs2740485, rs2740487, rs2777793, rs2777799, rs2777801, rs33918808, rs363717, rs3858074, rs3887137, rs3890182, rs3905001, rs4149262, rs4149263, rs4149264, rs4149265, rs4149268, rs4149271, rs4149291, rs4149312, rs4149336, rs4149338, rs6479283 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:99607
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-9826'