AutismKB 2.0

Annotation Details for S1PR1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:S1PR1 ( CHEDG1,D1S3362,ECGF1,EDG-1,EDG1,FLJ58121,S1P1 )
Gene Full Name: sphingosine-1-phosphate receptor 1
Band: 1p21.2
Quick LinksEntrez ID:1901; OMIM: 601974; Uniprot ID:S1PR1_HUMAN; ENSEMBL ID: ENSG00000170989; HGNC ID: 3165
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654IDA-nucleoplasm-
GO:0005768IEA-endosome-
GO:0005886TAS-plasma membrane-
GO:0009897IEA-external side of plasma membrane-
GO:0016021IEA-integral component of membrane-
GO:0031226IDA-intrinsic component of plasma membrane22344443
GO:0043231IDA-intracellular membrane-bounded organelle-
GO:0045121IEA-membrane raft-
GO ID Evidence Qualifier GO_term References
GO:0001664IPI-G-protein coupled receptor binding24851274
GO:0004930TAS-G-protein coupled receptor activity8626678
GO:0038036IDA-sphingosine-1-phosphate receptor activity22344443
GO:0046625IEA-sphingolipid binding-
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001955ISS-blood vessel maturation-
GO:0003245ISS-cardiac muscle tissue growth involved in heart morphogenesis-
GO:0003376IDA-sphingosine-1-phosphate signaling pathway22344443
GO:0006935ISS-chemotaxis-
GO:0007155TAS-cell adhesion9488656
GO:0007186TAS-G-protein coupled receptor signaling pathway8626678
GO:0007193IEA-adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway-
GO:0007420IEA-brain development-
GO:0016477ISS-cell migration-
GO:0019226IEA-transmission of nerve impulse-
GO:0030032ISS-lamellipodium assembly-
GO:0030155IEA-regulation of cell adhesion-
GO:0030182IEA-neuron differentiation-
GO:0030335IEA-positive regulation of cell migration-
GO:0030500ISS-regulation of bone mineralization-
GO:0030595IEA-leukocyte chemotaxis-
GO:0031532ISS-actin cytoskeleton reorganization-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0045124ISS-regulation of bone resorption-
GO:0045446IEA-endothelial cell differentiation-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0048661IEA-positive regulation of smooth muscle cell proliferation-
GO:0050927IEA-positive regulation of positive chemotaxis-
GO:0051482IEA-positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-
GO:0051497IEA-negative regulation of stress fiber assembly-
GO:0061384ISS-heart trabecula morphogenesis-
GO:0072678ISS-T cell migration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
S1PR1CAV110730510921915 Affinity Capture-Western
S1PR1CAV110822510921915 Affinity Capture-Western
GNAI1S1PR11090328626678 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GNAI1S1PR11082258626678 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GNAI3S1PR11090358626678 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
GNAI3S1PR11082258626678 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
HTR1AS1PR110958211854302 Affinity Capture-Western
HTR1AS1PR110822511854302 Affinity Capture-Western
HTR1DS1PR110958411854302 Affinity Capture-Western
HTR1DS1PR110822511854302 Affinity Capture-Western
PDGFRBS1PR111118512480944 Affinity Capture-Western
PDGFRBS1PR110822512480944 Affinity Capture-Western
TRIP6S1PR111305619293149 Affinity Capture-Western
TRIP6S1PR110822519293149 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1096355
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-001228-2'