AutismKB 2.0

Annotation Details for EIF2C4


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Basic Information Top
Gene Symbol:EIF2C4 ( AGO4 )
Gene Full Name: eukaryotic translation initiation factor 2C, 4
Band: 1p34.3
Quick LinksEntrez ID:192670; OMIM: 607356; Uniprot ID:AGO4_HUMAN; ENSEMBL ID: ENSG00000134698; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000932IEA-P-body-
GO:0005654IDA-nucleoplasm-
GO:0005737IDA-cytoplasm15260970
GO:0005829IDA-cytosol-
GO:0005829TAS-cytosol-
GO:0016020IDA-membrane19946888
GO:0016442IDA-RISC complex15260970
GO:0016604IDA-nuclear body-
GO:0035068IEA-micro-ribonucleoprotein complex-
GO:0070578IDA-RISC-loading complex19966796
GO ID Evidence Qualifier GO_term References
GO:0003725IDA-double-stranded RNA binding19966796
GO:0003727IDA-single-stranded RNA binding19966796
GO:0005515IPI-protein binding15766526
GO:0035198IDA-miRNA binding15260970
GO ID Evidence Qualifier GO_term References
GO:0006402IDA-mRNA catabolic process18771919
GO:0007130IEA-synaptonemal complex assembly-
GO:0007140IEA-male meiotic nuclear division-
GO:0007223TAS-Wnt signaling pathway, calcium modulating pathway-
GO:0008584IEA-male gonad development-
GO:0010501IDA-RNA secondary structure unwinding19966796
GO:0010501IMP-RNA secondary structure unwinding22795694
GO:0010586IEA-miRNA metabolic process-
GO:0022604IEA-regulation of cell morphogenesis-
GO:0031054IDA-pre-miRNA processing19966796
GO:0035194TAS-posttranscriptional gene silencing by RNA-
GO:0035196IMP-production of miRNAs involved in gene silencing by miRNA22795694
GO:0035278IDA-miRNA mediated inhibition of translation18771919
GO:0035279IDANOTmRNA cleavage involved in gene silencing by miRNA15260970
GO:0035280IDA-miRNA loading onto RISC involved in gene silencing by miRNA19966796
GO:0043066IEA-negative regulation of apoptotic process-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0090625IDANOTmRNA cleavage involved in gene silencing by siRNA15260970
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF2C4DICER112817812906857 Affinity Capture-Western
EIF2C4DICER111697812906857 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1924100
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

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Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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