AutismKB 2.0

Annotation Details for EGF


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Basic Information Top
Gene Symbol:EGF ( HOMG4,URG )
Gene Full Name: epidermal growth factor
Band: 4q25
Quick LinksEntrez ID:1950; OMIM: 131530; Uniprot ID:EGF_HUMAN; ENSEMBL ID: ENSG00000138798; HGNC ID: 3229
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IC-extracellular region9712850
GO:0005576TAS-extracellular region-
GO:0005615IDA-extracellular space16502470
GO:0005765IDA-lysosomal membrane17897319
GO:0005886IBA-plasma membrane-
GO:0016021IEA-integral component of membrane-
GO:0030665TAS-clathrin-coated vesicle membrane-
GO:0031093TAS-platelet alpha granule lumen-
GO:0043235IBA-receptor complex-
GO:0070062IDA-extracellular exosome19056867
GO ID Evidence Qualifier GO_term References
GO:0004713EXP-protein tyrosine kinase activity17349580
GO:0004713TAS-protein tyrosine kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005154TAS-epidermal growth factor receptor binding9712850
GO:0005509IEA-calcium ion binding-
GO:0005515IPI-protein binding2790960
GO:0008083IDA-growth factor activity7736574
GO:0017147IBA-Wnt-protein binding-
GO:0030297TAS-transmembrane receptor protein tyrosine kinase activator activity9712850
GO:0042813IBA-Wnt-activated receptor activity-
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0000186IEA-activation of MAPKK activity-
GO:0000187IEA-activation of MAPK activity-
GO:0001525IDA-angiogenesis15611079
GO:0002092IDA-positive regulation of receptor internalization22732145
GO:0002576TAS-platelet degranulation-
GO:0006260TAS-DNA replication9482941
GO:0007165TAS-signal transduction-
GO:0007171IEA-activation of transmembrane receptor protein tyrosine kinase activity-
GO:0007173TAS-epidermal growth factor receptor signaling pathway-
GO:0007262ISS-STAT protein import into nucleus-
GO:0008284IDA-positive regulation of cell proliferation7736574
GO:0010800IDA-positive regulation of peptidyl-threonine phosphorylation16314496
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0018108IEA-peptidyl-tyrosine phosphorylation-
GO:0021940IEA-positive regulation of cerebellar granule cell precursor proliferation-
GO:0035413IDA-positive regulation of catenin import into nucleus20302655
GO:0038128TAS-ERBB2 signaling pathway-
GO:0042059TAS-negative regulation of epidermal growth factor receptor signaling pathway-
GO:0042327IDA-positive regulation of phosphorylation15611079
GO:0043388ISS-positive regulation of DNA binding-
GO:0043406IDA-positive regulation of MAP kinase activity15611079
GO:0043547IEA-positive regulation of GTPase activity-
GO:0044332IBA-Wnt signaling pathway involved in dorsal/ventral axis specification-
GO:0045741IDA-positive regulation of epidermal growth factor-activated receptor activity15611079
GO:0045741IMP-positive regulation of epidermal growth factor-activated receptor activity22732145
GO:0045741TAS-positive regulation of epidermal growth factor-activated receptor activity9712850
GO:0045840IDA-positive regulation of mitotic nuclear division15611079
GO:0045893IDA-positive regulation of transcription, DNA-templated16314496
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048754IEA-branching morphogenesis of an epithelial tube-
GO:0051048IDA-negative regulation of secretion10559227
GO:0060059IBA-embryonic retina morphogenesis in camera-type eye-
GO:0060070IBA-canonical Wnt signaling pathway-
GO:0060749IEA-mammary gland alveolus development-
GO:0061024TAS-membrane organization-
GO:0070371IDA-ERK1 and ERK2 cascade16314496
GO:0090279IDA-regulation of calcium ion import19996314
GO:0090370IEA-negative regulation of cholesterol efflux-
GO:1900127IDA-positive regulation of hyaluronan biosynthetic process17324121
GO:1901185TAS-negative regulation of ERBB signaling pathway-
GO:2000008IDA-regulation of protein localization to cell surface19996314
GO:2000060IEA-positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process-
GO:2000145TAS-regulation of cell motility-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
PIK3R2EGF1113141334406 Biochemical Activity; Reconstituted Complex
PIK3R2EGF1082701334406 Biochemical Activity; Reconstituted Complex
RPS6KA5EGF1146769687510 Phenotypic Enhancement
RPS6KA5EGF1082709687510 Phenotypic Enhancement
MAPKAPK2EGF1146839687510 Phenotypic Enhancement
MAPKAPK2EGF1082709687510 Phenotypic Enhancement
EGFREGF10827010085134 12093292 Reconstituted Complex
EGFREGF10827610085134 12093292 Reconstituted Complex
EGFEGF10827011438527 Co-crystal Structure
VTNEGF11328711796824 Reconstituted Complex
VTNEGF10827011796824 Reconstituted Complex
ERBB2EGF10837612093292 Reconstituted Complex
ERBB2EGF10827012093292 Reconstituted Complex
ERBB3EGF10837712093292 Reconstituted Complex
ERBB3EGF10827012093292 Reconstituted Complex
FNBP1EGF11668615252009 Co-localization
FNBP1EGF10827015252009 Co-localization
No data
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
EGFrs2237042, rs2237054, rs3733625, rs3822288, rs4444903 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:95290
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-070922-1'