Annotation Details for EGFR


Gene Symbol: | EGFR ( ERBB,ERBB1,HER1,PIG61,mENA ) |
---|---|
Gene Full Name: | epidermal growth factor receptor |
Band: | 7p11.2 |
Quick Links | Entrez ID:1956; OMIM: 131550; Uniprot ID:EGFR_HUMAN; ENSEMBL ID: ENSG00000146648; HGNC ID: 3236 |
Relate to Another Database: | SFARIGene; denovo-db |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0000139 | IEA | - | Golgi membrane | - |
GO:0005615 | NAS | - | extracellular space | 9103388 |
GO:0005634 | IDA | - | nucleus | 12828935 |
GO:0005737 | IDA | - | cytoplasm | 7588596 |
GO:0005768 | IDA | - | endosome | 14702346 |
GO:0005768 | IDA | colocalizes_with | endosome | 16554368 |
GO:0005789 | IEA | - | endoplasmic reticulum membrane | - |
GO:0005886 | IDA | - | plasma membrane | 15465819 |
GO:0005886 | TAS | - | plasma membrane | - |
GO:0005925 | IDA | - | focal adhesion | 21423176 |
GO:0009986 | IDA | - | cell surface | 25666625 |
GO:0010008 | IDA | - | endosome membrane | 22719997 |
GO:0016020 | IDA | - | membrane | 12435727 |
GO:0016021 | IEA | - | integral component of membrane | - |
GO:0016323 | IDA | - | basolateral plasma membrane | 12646923 |
GO:0016324 | IEA | - | apical plasma membrane | - |
GO:0030122 | TAS | colocalizes_with | AP-2 adaptor complex | 14702346 |
GO:0030665 | TAS | - | clathrin-coated vesicle membrane | - |
GO:0031901 | IDA | - | early endosome membrane | 17714434 |
GO:0031965 | IEA | - | nuclear membrane | - |
GO:0043235 | IDA | - | receptor complex | 23382219 |
GO:0045121 | IDA | - | membrane raft | 12009895 |
GO:0045202 | IEA | - | synapse | - |
GO:0048471 | IEA | - | perinuclear region of cytoplasm | - |
GO:0070435 | ISS | - | Shc-EGFR complex | - |
GO:0097489 | IDA | - | multivesicular body, internal vesicle lumen | 17714434 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0001948 | IEA | - | glycoprotein binding | - |
GO:0003682 | IDA | - | chromatin binding | 20551055 |
GO:0003690 | NAS | - | double-stranded DNA binding | 6325948 |
GO:0004709 | NAS | - | MAP kinase kinase kinase activity | 15542601 |
GO:0004713 | EXP | - | protein tyrosine kinase activity | 17349580 |
GO:0004713 | IDA | - | protein tyrosine kinase activity | 17115032 |
GO:0004713 | IMP | - | protein tyrosine kinase activity | 14702346 |
GO:0004713 | TAS | - | protein tyrosine kinase activity | 16076471 |
GO:0004714 | TAS | - | transmembrane receptor protein tyrosine kinase activity | - |
GO:0004716 | IEA | - | signal transducer, downstream of receptor, with protein tyrosine kinase activity | - |
GO:0004888 | IDA | - | transmembrane signaling receptor activity | 7736574 |
GO:0005006 | IDA | - | epidermal growth factor-activated receptor activity | 12435727 |
GO:0005006 | IMP | - | epidermal growth factor-activated receptor activity | 22732145 |
GO:0005006 | NAS | - | epidermal growth factor-activated receptor activity | 2790960 |
GO:0005088 | TAS | - | Ras guanyl-nucleotide exchange factor activity | - |
GO:0005178 | IEA | - | integrin binding | - |
GO:0005515 | IPI | - | protein binding | 2176151 |
GO:0005516 | IEA | - | calmodulin binding | - |
GO:0005524 | IEA | - | ATP binding | - |
GO:0019899 | IPI | - | enzyme binding | 12009895 |
GO:0019901 | IEA | - | protein kinase binding | - |
GO:0019903 | IPI | - | protein phosphatase binding | 15899872 |
GO:0030235 | IDA | contributes_to | nitric-oxide synthase regulator activity | 12828935 |
GO:0031625 | IPI | - | ubiquitin protein ligase binding | 23418353 |
GO:0042802 | IPI | - | identical protein binding | 16777603 |
GO:0045296 | IDA | - | cadherin binding | 25468996 |
GO:0046934 | TAS | - | phosphatidylinositol-4,5-bisphosphate 3-kinase activity | - |
GO:0046982 | IDA | - | protein heterodimerization activity | 10572067 |
GO:0048408 | IEA | - | epidermal growth factor binding | - |
GO:0051015 | IDA | - | actin filament binding | 14702346 |
GO ID | Evidence | Qualifier | GO_term | References |
---|---|---|---|---|
GO:0000165 | TAS | - | MAPK cascade | - |
GO:0000186 | IEA | - | activation of MAPKK activity | - |
GO:0001503 | NAS | - | ossification | 12925580 |
GO:0001892 | IEA | - | embryonic placenta development | - |
GO:0001934 | IDA | - | positive regulation of protein phosphorylation | 20551055 |
GO:0001942 | IEA | - | hair follicle development | - |
GO:0006357 | TAS | - | regulation of transcription from RNA polymerase II promoter | - |
GO:0006412 | IEA | - | translation | - |
GO:0006950 | NAS | - | response to stress | 12828935 |
GO:0006970 | IEA | - | response to osmotic stress | - |
GO:0007165 | IDA | - | signal transduction | 10572067 |
GO:0007165 | TAS | - | signal transduction | - |
GO:0007166 | IDA | - | cell surface receptor signaling pathway | 7736574 |
GO:0007173 | IDA | - | epidermal growth factor receptor signaling pathway | 7736574 |
GO:0007173 | TAS | - | epidermal growth factor receptor signaling pathway | - |
GO:0007202 | TAS | - | activation of phospholipase C activity | 12435727 |
GO:0007435 | IEA | - | salivary gland morphogenesis | - |
GO:0007494 | IEA | - | midgut development | - |
GO:0007611 | ISS | - | learning or memory | - |
GO:0007623 | IEA | - | circadian rhythm | - |
GO:0008283 | IDA | - | cell proliferation | 17115032 |
GO:0008284 | IDA | - | positive regulation of cell proliferation | 7736574 |
GO:0008284 | IMP | - | positive regulation of cell proliferation | 27057632 |
GO:0010960 | IEA | - | magnesium ion homeostasis | - |
GO:0014066 | IMP | - | regulation of phosphatidylinositol 3-kinase signaling | 26514923 |
GO:0014066 | TAS | - | regulation of phosphatidylinositol 3-kinase signaling | - |
GO:0016101 | IEA | - | diterpenoid metabolic process | - |
GO:0016337 | IMP | - | single organismal cell-cell adhesion | 12435727 |
GO:0018108 | IDA | - | peptidyl-tyrosine phosphorylation | 22732145 |
GO:0021795 | IEA | - | cerebral cortex cell migration | - |
GO:0030307 | IDA | - | positive regulation of cell growth | 15467833 |
GO:0030324 | IEA | - | lung development | - |
GO:0030335 | IMP | - | positive regulation of cell migration | 12435727 |
GO:0031659 | IDA | - | positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle | 18483258 |
GO:0032930 | IEA | - | positive regulation of superoxide anion generation | - |
GO:0033590 | IEA | - | response to cobalamin | - |
GO:0033594 | IEA | - | response to hydroxyisoflavone | - |
GO:0034614 | IMP | - | cellular response to reactive oxygen species | 26514923 |
GO:0035413 | IMP | - | positive regulation of catenin import into nucleus | 20302655 |
GO:0035690 | IEA | - | cellular response to drug | - |
GO:0038083 | TAS | - | peptidyl-tyrosine autophosphorylation | 22732145 |
GO:0038128 | TAS | - | ERBB2 signaling pathway | - |
GO:0042059 | TAS | - | negative regulation of epidermal growth factor receptor signaling pathway | - |
GO:0042060 | IEA | - | wound healing | - |
GO:0042177 | IDA | - | negative regulation of protein catabolic process | 17115032 |
GO:0042327 | IDA | - | positive regulation of phosphorylation | 15082764 |
GO:0042698 | IEA | - | ovulation cycle | - |
GO:0042743 | IEA | - | hydrogen peroxide metabolic process | - |
GO:0043006 | TAS | - | activation of phospholipase A2 activity by calcium-mediated signaling | 12435727 |
GO:0043066 | IMP | - | negative regulation of apoptotic process | 18070883 |
GO:0043406 | IDA | - | positive regulation of MAP kinase activity | 10572067 |
GO:0043547 | IEA | - | positive regulation of GTPase activity | - |
GO:0043586 | IEA | - | tongue development | - |
GO:0045429 | IDA | - | positive regulation of nitric oxide biosynthetic process | 12828935 |
GO:0045739 | IDA | - | positive regulation of DNA repair | 17115032 |
GO:0045740 | IDA | - | positive regulation of DNA replication | 17115032 |
GO:0045780 | IEA | - | positive regulation of bone resorption | - |
GO:0045893 | IMP | - | positive regulation of transcription, DNA-templated | 26514923 |
GO:0045907 | IEA | - | positive regulation of vasoconstriction | - |
GO:0045930 | IEA | - | negative regulation of mitotic cell cycle | - |
GO:0045944 | IDA | - | positive regulation of transcription from RNA polymerase II promoter | 20551055 |
GO:0046328 | IMP | - | regulation of JNK cascade | 26514923 |
GO:0046777 | IMP | - | protein autophosphorylation | 18070883 |
GO:0046854 | IEA | - | phosphatidylinositol phosphorylation | - |
GO:0048015 | TAS | - | phosphatidylinositol-mediated signaling | - |
GO:0048143 | IEA | - | astrocyte activation | - |
GO:0048146 | IEA | - | positive regulation of fibroblast proliferation | - |
GO:0048546 | IEA | - | digestive tract morphogenesis | - |
GO:0048661 | IEA | - | positive regulation of smooth muscle cell proliferation | - |
GO:0048812 | IEA | - | neuron projection morphogenesis | - |
GO:0050679 | IDA | - | positive regulation of epithelial cell proliferation | 10572067 |
GO:0050729 | IEA | - | positive regulation of inflammatory response | - |
GO:0050730 | IMP | - | regulation of peptidyl-tyrosine phosphorylation | 12435727 |
GO:0050999 | IDA | - | regulation of nitric-oxide synthase activity | 12828935 |
GO:0051205 | TAS | - | protein insertion into membrane | 12435727 |
GO:0051592 | IEA | - | response to calcium ion | - |
GO:0051897 | IMP | - | positive regulation of protein kinase B signaling | 17655843 |
GO:0051968 | IEA | - | positive regulation of synaptic transmission, glutamatergic | - |
GO:0060571 | IEA | - | morphogenesis of an epithelial fold | - |
GO:0061024 | TAS | - | membrane organization | - |
GO:0061029 | IEA | - | eyelid development in camera-type eye | - |
GO:0070141 | IDA | - | response to UV-A | 18483258 |
GO:0070372 | IMP | - | regulation of ERK1 and ERK2 cascade | 26514923 |
GO:0070374 | IDA | - | positive regulation of ERK1 and ERK2 cascade | 20551055 |
GO:0070374 | IMP | - | positive regulation of ERK1 and ERK2 cascade | 21673316 |
GO:0071230 | IEA | - | cellular response to amino acid stimulus | - |
GO:0071260 | IEA | - | cellular response to mechanical stimulus | - |
GO:0071276 | IMP | - | cellular response to cadmium ion | 26514923 |
GO:0071364 | ISS | - | cellular response to epidermal growth factor stimulus | - |
GO:0071392 | IDA | - | cellular response to estradiol stimulus | 20551055 |
GO:0071549 | IEA | - | cellular response to dexamethasone stimulus | - |
GO:0097421 | IEA | - | liver regeneration | - |
GO:0097755 | IEA | - | positive regulation of blood vessel diameter | - |
GO:1900020 | IDA | - | positive regulation of protein kinase C activity | 22732145 |
GO:1901185 | TAS | - | negative regulation of ERBB signaling pathway | - |
GO:1901224 | IMP | - | positive regulation of NIK/NF-kappaB signaling | 26514923 |
GO:1902722 | IEA | - | positive regulation of prolactin secretion | - |
GO:1903078 | IDA | - | positive regulation of protein localization to plasma membrane | 22732145 |
GO:1903800 | IMP | - | positive regulation of production of miRNAs involved in gene silencing by miRNA | 21673316 |
GO:1905208 | IMP | - | negative regulation of cardiocyte differentiation | 23069713 |
GO:2000145 | TAS | - | regulation of cell motility | - |
Gene Symbol | Interactant | Interaction ID | References | Description |
---|---|---|---|---|
FOS | EGFR | 300545 | 15950906 | An unspecified isoform of EGFR binds to c-fos promoter. |
GRB10 | EGFR | 183784 | 9506989 | Grb10 interacts with EGFR. |
GRB2 | EGFR | 215881 | 15782189 | GRB2 interacts with an unspecified isoform of EGFR. This interaction was modeled on a demonstrated interaction between human GRB2, and rat EGFR. |
SHC1 | EGFR | 180620 | 8887653 | EGF-R interacts with Shc. This interaction was modelled on a demonstrated interaction between human EGF-R and mouse Shc. |
YWHAZ | EGFR | 185503 | 15225635 | EGFR interacts with 14-3-3-zeta. |
No data |
No data |
No data |
Gene Symbol | Poly Names | Gene overview in SZGene |
---|---|---|
EGFR | rs10241451, rs12538371, rs1344307, rs1525642, rs2072454, rs2075106, rs2075107, rs2075112, rs2110290, rs2192293, rs2241054, rs2293347, rs2293348, rs2740762, rs3823585, rs4245566, rs524529, rs6593210, rs6947594, rs6964705, rs6969564, rs6970262, rs729969, rs759160, rs759162, rs759170, rs7787739, rs7806790, rs845551, rs883117, rs884225 | Gene overview in SZGene |
- MGI ID: MGI:95294
- Data Attributes: MGI curated and HomoloGene calculated
- ZFIN ID: ZDB-GENE-030918-1