Annotation Details for MLKL

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Basic Information Top

Gene Symbol:	MLKL ( FLJ34389 )
Gene Full Name:	mixed lineage kinase domain-like
Band:	16q22.3
Quick Links	Entrez ID:197259; OMIM: NA; Uniprot ID:MLKL_HUMAN; ENSEMBL ID: ENSG00000168404; HGNC ID: 26617
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:3 results
Molecular Function:7 results
Biological Process:5 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005737	IDA	-	cytoplasm	24316671
GO:0005829	TAS	-	cytosol	-
GO:0005886	IDA	-	plasma membrane	24316671

GO ID	Evidence	Qualifier	GO_term	References
GO:0004672	IBA	NOT	protein kinase activity	-
GO:0004672	ISS	NOT	protein kinase activity	-
GO:0004871	IBA	-	signal transducer activity	-
GO:0005515	IPI	-	protein binding	22265413
GO:0005524	IDA	-	ATP binding	24219132
GO:0019901	IEA	-	protein kinase binding	-
GO:0032403	IDA	-	protein complex binding	22265414

GO ID	Evidence	Qualifier	GO_term	References
GO:0006468	IBA	NOT	protein phosphorylation	-
GO:0035556	IBA	-	intracellular signal transduction	-
GO:0070207	IDA	-	protein homotrimerization	24316671
GO:0070266	IMP	-	necroptotic process	22265413
GO:0070266	TAS	-	necroptotic process	-

Protein-Protein Interaction

BioGRID:2 results
BIND:0 results
HPRD:0 results

Gene Symbol	Interactant	Interaction ID	References	Description
MLKL	PITPNA	128244	17353931	Affinity Capture-MS
MLKL	PITPNA	111323	17353931	Affinity Capture-MS

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:1921818
Data Attributes: HomoloGene calculated

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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