Annotation Details for NLRC3

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Basic Information Top

Gene Symbol:	NLRC3 ( CLR16.2,FLJ00348,NOD3 )
Gene Full Name:	NLR family, CARD domain containing 3
Band:	16p13.3
Quick Links	Entrez ID:197358; OMIM: NA; Uniprot ID:NLRC3_HUMAN; ENSEMBL ID: ENSG00000167984; HGNC ID: 29889
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

AlzGene, PDGene and SZGene

Gene Ontology

Cellular Component:4 results
Molecular Function:4 results
Biological Process:18 results

GO ID	Evidence	Qualifier	GO_term	References
GO:0005737	IDA	-	cytoplasm	15705585
GO:0005815	IDA	-	microtubule organizing center	-
GO:0005829	IDA	-	cytosol	-
GO:0048471	IDA	-	perinuclear region of cytoplasm	24560620

GO ID	Evidence	Qualifier	GO_term	References
GO:0003674	ND	-	molecular_function	-
GO:0005515	IPI	-	protein binding	24560620
GO:0005524	IEA	-	ATP binding	-
GO:0036312	ISS	-	phosphatidylinositol 3-kinase regulatory subunit binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0007249	IDA	-	I-kappaB kinase/NF-kappaB signaling	15705585
GO:0014067	ISS	-	negative regulation of phosphatidylinositol 3-kinase signaling	-
GO:0032088	IDA	-	negative regulation of NF-kappaB transcription factor activity	15705585
GO:0032687	ISS	-	negative regulation of interferon-alpha production	-
GO:0032688	ISS	-	negative regulation of interferon-beta production	-
GO:0032715	IDA	-	negative regulation of interleukin-6 production	22863753
GO:0032715	IMP	-	negative regulation of interleukin-6 production	22863753
GO:0032720	IDA	-	negative regulation of tumor necrosis factor production	22863753
GO:0032720	IMP	-	negative regulation of tumor necrosis factor production	22863753
GO:0042110	IEP	-	T cell activation	15705585
GO:0043124	IMP	-	negative regulation of I-kappaB kinase/NF-kappaB signaling	22863753
GO:0045824	ISS	-	negative regulation of innate immune response	-
GO:0048147	ISS	-	negative regulation of fibroblast proliferation	-
GO:0050680	ISS	-	negative regulation of epithelial cell proliferation	-
GO:0050728	IDA	-	negative regulation of inflammatory response	25277106
GO:1900016	ISS	-	negative regulation of cytokine production involved in inflammatory response	-
GO:1900226	IDA	-	negative regulation of NLRP3 inflammasome complex assembly	25277106
GO:1901223	IDA	-	negative regulation of NIK/NF-kappaB signaling	25277106

Protein-Protein Interaction

AlzGene, PDGene and SZGene

Animal Model

Mouse:1 results
Fruit Fly:0 results

MGI ID: MGI:2444070
Data Attributes: HomoloGene calculated