AutismKB 2.0

Annotation Details for EIF4E


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Basic Information Top
Gene Symbol:EIF4E ( CBP,EIF4E1,EIF4EL1,EIF4F,MGC111573 )
Gene Full Name: eukaryotic translation initiation factor 4E
Band: 4q23
Quick LinksEntrez ID:1977; OMIM: 133440; Uniprot ID:IF4E_HUMAN; ENSEMBL ID: ENSG00000151247; HGNC ID: 3287
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000932IDA-P-body20616046
GO:0005737IDA-cytoplasm19393246
GO:0005829IDA-cytosol19750007
GO:0005829TAS-cytosol-
GO:0005845IDA-mRNA cap binding complex16271312
GO:0010494IDA-cytoplasmic stress granule21883093
GO:0016281IDA-eukaryotic translation initiation factor 4F complex22578813
GO:0016442IDA-RISC complex20616046
GO:0033391IEA-chromatoid body-
GO:0048471IDA-perinuclear region of cytoplasm23814182
GO:0070062IDA-extracellular exosome20458337
GO ID Evidence Qualifier GO_term References
GO:0000339TAS-RNA cap binding3469651
GO:0000340IDA-RNA 7-methylguanosine cap binding19750007
GO:0003723IDA-RNA binding22681889
GO:0003743IDA-translation initiation factor activity22578813
GO:0003743ISS-translation initiation factor activity-
GO:0005515IPI-protein binding7651417
GO:0019899IDA-enzyme binding23814182
GO:0031370IDA-eukaryotic initiation factor 4G binding23814182
GO:0070491IDA-repressing transcription factor binding23814182
GO ID Evidence Qualifier GO_term References
GO:0000082IMP-G1/S transition of mitotic cell cycle14673156
GO:0000289TAS-nuclear-transcribed mRNA poly(A) tail shortening-
GO:0001662IEA-behavioral fear response-
GO:0006405TAS-RNA export from nucleus-
GO:0006406TAS-mRNA export from nucleus-
GO:0006413TAS-translational initiation-
GO:0006417IDA-regulation of translation22578813
GO:0010507IMPNOTnegative regulation of autophagy18426977
GO:0016032IEA-viral process-
GO:0017148IEA-negative regulation of translation-
GO:0019827IEA-stem cell population maintenance-
GO:0030324IEA-lung development-
GO:0045665IEA-negative regulation of neuron differentiation-
GO:0045931IMP-positive regulation of mitotic cell cycle14673156
GO:0071549IEA-cellular response to dexamethasone stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF4EEIF4A110828916648488 17353931 Affinity Capture-MS; Affinity Capture-Western
EIF4EEIF4A110829216648488 17353931 Affinity Capture-MS; Affinity Capture-Western
EIF4EEIF4A210829017353931 Affinity Capture-MS
EIF4EEIF4A210829217353931 Affinity Capture-MS
EIF4EBP1EIF4E1082927651417 10364159 10405182 10698949 10753870 11605658 12071973 16189514 16242075 16648488 16824195 17353931 18957614 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
EIF4EBP1EIF4E1082937651417 10364159 10405182 10698949 10753870 11605658 12071973 16189514 16242075 16648488 16824195 17353931 18957614 Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
EIF4G1EIF4E1082927651417 10600798 10753870 16541103 16648488 16720573 Affinity Capture-Western; Far Western
EIF4G1EIF4E1082967651417 10600798 10753870 16541103 16648488 16720573 Affinity Capture-Western; Far Western
EIF4EBP2EIF4E1082927651417 7935836 Reconstituted Complex
EIF4EBP2EIF4E1082947651417 7935836 Reconstituted Complex
EIF4G2EIF4E1082979418880 Affinity Capture-Western; Far Western
EIF4G2EIF4E1082929418880 Affinity Capture-Western; Far Western
EIF4EBP3EIF4E1141909593750 12482586 Affinity Capture-Western
EIF4EBP3EIF4E1082929593750 12482586 Affinity Capture-Western
MKNK1EIF4E1141389878069 Affinity Capture-Western
MKNK1EIF4E1082929878069 Affinity Capture-Western
EIF4ENIF1EIF4E12114810856257 Affinity Capture-Western; Far Western
EIF4ENIF1EIF4E10829210856257 Affinity Capture-Western; Far Western
PMLEIF4E11138411500381 Reconstituted Complex
PMLEIF4E10829211500381 Reconstituted Complex
EIF3BEIF4E11421116541103 Affinity Capture-Western
EIF3BEIF4E10829216541103 Affinity Capture-Western
EIF4EEIF4E10829216648488 Affinity Capture-Western
STUB1EIF4E10829216720573 Affinity Capture-Western
STUB1EIF4E11556316720573 Affinity Capture-Western
UBCEIF4E11316416720573 Affinity Capture-Western
UBCEIF4E10829216720573 Affinity Capture-Western
EIF3FEIF4E11421419615732 Affinity Capture-MS
EIF3FEIF4E10829219615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95305
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-040413-1'