AutismKB 2.0

Annotation Details for EIF4G1


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Basic Information Top
Gene Symbol:EIF4G1 ( DKFZp686A1451,EIF-4G1,EIF4F,EIF4G,EIF4GI,P220 )
Gene Full Name: eukaryotic translation initiation factor 4 gamma, 1
Band: 3q27.1
Quick LinksEntrez ID:1981; OMIM: 600495; Uniprot ID:IF4G1_HUMAN; ENSEMBL ID: ENSG00000114867; HGNC ID: 3296
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IMP-nucleus18426977
GO:0005737IDA-cytoplasm23814182
GO:0005737IMP-cytoplasm18426977
GO:0005829TAS-cytosol-
GO:0005844IMP-polysome18426977
GO:0016020IDA-membrane19946888
GO:0016281IDA-eukaryotic translation initiation factor 4F complex25255371
GO:0022627TAScolocalizes_withcytosolic small ribosomal subunit25765080
GO ID Evidence Qualifier GO_term References
GO:0003723IDA-RNA binding22658674
GO:0003723TAS-RNA binding25255371
GO:0003729IDA-mRNA binding24092755
GO:0003743TAS-translation initiation factor activity8961935
GO:0005515IPI-protein binding10523622
GO:0005524IDA-ATP binding25255371
GO:0008135IMP-translation factor activity, RNA binding18426977
GO:0008190IDA-eukaryotic initiation factor 4E binding23814182
GO:0008190TAS-eukaryotic initiation factor 4E binding25765080
GO:0031369TAS-translation initiation factor binding25765080
GO:0032947TAS-protein complex scaffold25255371
GO:0045296IDA-cadherin binding25468996
GO ID Evidence Qualifier GO_term References
GO:0000184TAS-nuclear-transcribed mRNA catabolic process, nonsense-mediated decay-
GO:0000289TAS-nuclear-transcribed mRNA poly(A) tail shortening-
GO:0001662IEA-behavioral fear response-
GO:0002191TAS-cap-dependent translational initiation25765080
GO:0006412IMP-translation18426977
GO:0006412IPI-translation24092755
GO:0006413NAS-translational initiation25255371
GO:0006413TAS-translational initiation18426977
GO:0006446IMP-regulation of translational initiation19648179
GO:0006446NAS-regulation of translational initiation8961935
GO:0007005IMP-mitochondrion organization18426977
GO:0008284IMP-positive regulation of cell proliferation18426977
GO:0010507IMP-negative regulation of autophagy18426977
GO:0010801IMP-negative regulation of peptidyl-threonine phosphorylation18426977
GO:0016032IEA-viral process-
GO:0030307IMP-positive regulation of cell growth18426977
GO:0032270IMP-positive regulation of cellular protein metabolic process18426977
GO:0032502TAS-developmental process25765080
GO:0033138IMP-positive regulation of peptidyl-serine phosphorylation18426977
GO:0034645IGI-cellular macromolecule biosynthetic process18426977
GO:0043488TAS-regulation of mRNA stability-
GO:0045666IEA-positive regulation of neuron differentiation-
GO:0060964TAS-regulation of gene silencing by miRNA25765080
GO:0080135TAS-regulation of cellular response to stress25765080
GO:1900087IMP-positive regulation of G1/S transition of mitotic cell cycle18426977
GO:1901215TAS-negative regulation of neuron death25765080
GO:1905537IMP-positive regulation of eukaryotic translation initiation factor 4F complex assembly18426977
GO:1905606IGI-regulation of presynapse assembly25533483
GO:1905612IDA-positive regulation of mRNA cap binding23409027
GO:1905618IDA-positive regulation of miRNA mediated inhibition of translation23409027
GO:1905696IMP-regulation of polysome binding18426977
GO:2000507IMP-positive regulation of energy homeostasis18426977
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EIF4G1EIF4A110828916541103 16648488 17353931 Affinity Capture-MS; Affinity Capture-Western
EIF4G1EIF4A110829616541103 16648488 17353931 Affinity Capture-MS; Affinity Capture-Western
EIF4G1EIF4A210829017353931 Affinity Capture-MS
EIF4G1EIF4A210829617353931 Affinity Capture-MS
EIF4G1EIF4E1082927651417 10600798 10753870 16541103 16648488 16720573 Affinity Capture-Western; Far Western
EIF4G1EIF4E1082967651417 10600798 10753870 16541103 16648488 16720573 Affinity Capture-Western; Far Western
PABPC1EIF4G11082969857202 Affinity Capture-Western; Reconstituted Complex
PABPC1EIF4G11179399857202 Affinity Capture-Western; Reconstituted Complex
MKNK1EIF4G11141389878069 Affinity Capture-Western; Reconstituted Complex
MKNK1EIF4G11082969878069 Affinity Capture-Western; Reconstituted Complex
NCBP1EIF4G111076611340157 Affinity Capture-Western
NCBP1EIF4G110829611340157 Affinity Capture-Western
PDCD4EIF4G110829612054647 Affinity Capture-Western
PDCD4EIF4G111809812054647 Affinity Capture-Western
MKNK2EIF4G110913012897141 Affinity Capture-Western; Biochemical Activity
MKNK2EIF4G110829612897141 Affinity Capture-Western; Biochemical Activity
EIF3AEIF4G111421016541103 Affinity Capture-Western
EIF3AEIF4G110829616541103 Affinity Capture-Western
EIF3BEIF4G111421116541103 Affinity Capture-Western
EIF3BEIF4G110829616541103 Affinity Capture-Western
EIF3IEIF4G111421716541103 Affinity Capture-Western
EIF3IEIF4G110829616541103 Affinity Capture-Western
GABARAPL2EIF4G111647317353931 Affinity Capture-MS
GABARAPL2EIF4G110829617353931 Affinity Capture-MS
MAGEA6EIF4G111027917353931 Affinity Capture-MS
MAGEA6EIF4G110829617353931 Affinity Capture-MS
TH1LEIF4G111957217353931 Affinity Capture-MS
TH1LEIF4G110829617353931 Affinity Capture-MS
HNRNPDEIF4G110942518573886 Affinity Capture-Western
HNRNPDEIF4G110829618573886 Affinity Capture-Western
G3BP1EIF4G110829619615732 Affinity Capture-MS
G3BP1EIF4G111544819615732 Affinity Capture-MS
EIF3FEIF4G111421419615732 Affinity Capture-MS
EIF3FEIF4G110829619615732 Affinity Capture-MS
EIF3HEIF4G110829619615732 Affinity Capture-MS
EIF3HEIF4G111421619615732 Affinity Capture-MS
USP10EIF4G110829619615732 Affinity Capture-MS
USP10EIF4G111455419615732 Affinity Capture-MS
USP3EIF4G110829619615732 Affinity Capture-MS
USP3EIF4G111528519615732 Affinity Capture-MS
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:2384784
  • Data Attributes: MGI curated and HomoloGene calculated
No data