AutismKB 2.0

Annotation Details for A2M


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Basic Information Top
Gene Symbol:A2M ( CPAMD5,DKFZp779B086,S863-7 )
Gene Full Name: alpha-2-macroglobulin
Band: 12p13.31
Quick LinksEntrez ID:2; OMIM: 103950; Uniprot ID:A2MG_HUMAN; ENSEMBL ID: ENSG00000175899; HGNC ID: 7
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576NAS-extracellular region14718574
GO:0005576TAS-extracellular region-
GO:0005829TAS-cytosol-
GO:0031093TAS-platelet alpha granule lumen-
GO:0070062IDA-extracellular exosome20458337
GO:0072562IDA-blood microparticle22516433
GO ID Evidence Qualifier GO_term References
GO:0002020IPI-protease binding18485748
GO:0004867IDA-serine-type endopeptidase inhibitor activity12538697
GO:0005096TAS-GTPase activator activity-
GO:0005102IMP-receptor binding15226301
GO:0005515IPI-protein binding6698368
GO:0019838IDA-growth factor binding9398211
GO:0019899IPI-enzyme binding11435418
GO:0019959IPI-interleukin-8 binding10880251
GO:0019966IDA-interleukin-1 binding9714181
GO:0043120IDA-tumor necrosis factor binding9714181
GO:0048306IPI-calcium-dependent protein binding15226301
GO ID Evidence Qualifier GO_term References
GO:0001869IDA-negative regulation of complement activation, lectin pathway12538697
GO:0002576TAS-platelet degranulation-
GO:0007597TAS-blood coagulation, intrinsic pathway-
GO:0010951IEA-negative regulation of endopeptidase activity-
GO:0022617TAS-extracellular matrix disassembly-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0048863IEA-stem cell differentiation-
GO:0051056TAS-regulation of small GTPase mediated signal transduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
AMBPA2M1065241697852 7519849 Affinity Capture-Western
AMBPA2M1067571697852 7519849 Affinity Capture-Western
KLK3A2M1068501702714 Affinity Capture-Western
KLK3A2M1065241702714 Affinity Capture-Western
CPB2A2M1077538662763 Reconstituted Complex
CPB2A2M1065248662763 Reconstituted Complex
MMP2A2M1065249344465 Reconstituted Complex
MMP2A2M1104579344465 Reconstituted Complex
LEPA2M1101439724081 Reconstituted Complex
LEPA2M1065249724081 Reconstituted Complex
APOEA2M1065249831625 Affinity Capture-Western; Reconstituted Complex
APOEA2M1068459831625 Affinity Capture-Western; Reconstituted Complex
ADAMTS1A2M11488810373500 Affinity Capture-Western
ADAMTS1A2M10652410373500 Affinity Capture-Western
LRP1A2M11021510652313 Co-crystal Structure
LRP1A2M10652410652313 Co-crystal Structure
NGFA2M11086910681572 Reconstituted Complex
NGFA2M10652410681572 Reconstituted Complex
IL4A2M10652410714547 Reconstituted Complex
IL4A2M10977910714547 Reconstituted Complex
IL10A2M10652410714547 Reconstituted Complex
IL10A2M10980010714547 Reconstituted Complex
B2MA2M10652410731476 Reconstituted Complex
B2MA2M10704410731476 Reconstituted Complex
PAEPA2M10652411023837 Co-purification; Reconstituted Complex
PAEPA2M11108411023837 Co-purification; Reconstituted Complex
LCATA2M10652411435418 Affinity Capture-Western; Reconstituted Complex
LCATA2M11012311435418 Affinity Capture-Western; Reconstituted Complex
HSPA5A2M10954112194978 Reconstituted Complex
HSPA5A2M10652412194978 Reconstituted Complex
KLK13A2M11753814687906 Reconstituted Complex
KLK13A2M10652414687906 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
A2Mrs10842898, rs1800433, rs1805654, rs226379, rs226380, rs3759277, rs3832852, rs669 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
A2Mrs226380, rs3759277, rs3832852, rs669 Gene overview in PDGene
No data
Animal Model Top
  • MGI ID: MGI:2449119
  • Data Attributes: MGI curated and HomoloGene calculated
No data
No data

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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