Gene Symbol:	EP300 ( KAT3B,p300 )
Gene Full Name:	E1A binding protein p300
Band:	22q13.2
Quick Links	Entrez ID:2033; OMIM: 602700; Uniprot ID:EP300_HUMAN; ENSEMBL ID: ENSG00000100393; HGNC ID: 3373
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000123	IEA	-	histone acetyltransferase complex	-
GO:0005634	IDA	-	nucleus	9194565
GO:0005654	IDA	-	nucleoplasm	-
GO:0005654	TAS	-	nucleoplasm	-
GO:0005667	IEA	-	transcription factor complex	-
GO:0005829	IDA	-	cytosol	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000979	IEA	-	RNA polymerase II core promoter sequence-specific DNA binding	-
GO:0001047	IDA	-	core promoter binding	17641689
GO:0001102	IPI	-	RNA polymerase II activating transcription factor binding	20018936
GO:0001228	IEA	-	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	-
GO:0002039	IEA	-	p53 binding	-
GO:0003677	IDA	-	DNA binding	9194565
GO:0003682	IDA	-	chromatin binding	24939902
GO:0003682	IMP	-	chromatin binding	17641689
GO:0003684	IDA	-	damaged DNA binding	24939902
GO:0003713	IDA	-	transcription coactivator activity	12435739
GO:0003713	IDA	contributes_to	transcription coactivator activity	12929931
GO:0004402	IDA	-	histone acetyltransferase activity	12040021
GO:0004402	TAS	-	histone acetyltransferase activity	-
GO:0004468	IDA	-	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	20019387
GO:0005515	IPI	-	protein binding	1331501
GO:0008013	IPI	-	beta-catenin binding	12408825
GO:0008022	IDA	-	protein C-terminus binding	17150957
GO:0008134	IPI	-	transcription factor binding	8684459
GO:0008270	IEA	-	zinc ion binding	-
GO:0016407	EXP	-	acetyltransferase activity	12456660
GO:0016407	IDA	-	acetyltransferase activity	18722353
GO:0016407	IMP	-	acetyltransferase activity	12435739
GO:0016746	IDA	-	transferase activity, transferring acyl groups	17403783
GO:0031490	IEA	-	chromatin DNA binding	-
GO:0033613	IPI	-	activating transcription factor binding	20590529
GO:0034212	TAS	-	peptide N-acetyltransferase activity	-
GO:0035257	IPI	-	nuclear hormone receptor binding	9862959
GO:0050681	IPI	-	androgen receptor binding	18487222
GO:0061733	TAS	-	peptide-lysine-N-acetyltransferase activity	-
GO:0097157	IEA	-	pre-mRNA intronic binding	-

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	IDA	-	negative regulation of transcription from RNA polymerase II promoter	10733570
GO:0001666	IDA	-	response to hypoxia	9887100
GO:0001756	IEA	-	somitogenesis	-
GO:0002223	TAS	-	stimulatory C-type lectin receptor signaling pathway	-
GO:0006283	TAS	-	transcription-coupled nucleotide-excision repair	-
GO:0006355	IDA	-	regulation of transcription, DNA-templated	15261140
GO:0006366	IEA	-	transcription from RNA polymerase II promoter	-
GO:0006473	IDA	-	protein acetylation	21030595
GO:0006473	TAS	-	protein acetylation	22013210
GO:0006475	IDA	-	internal protein amino acid acetylation	18722353
GO:0006915	IMP	-	apoptotic process	9194565
GO:0006977	TAS	-	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	-
GO:0006990	ISS	-	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response	-
GO:0007219	TAS	-	Notch signaling pathway	-
GO:0007399	TAS	-	nervous system development	10205054
GO:0007507	IEA	-	heart development	-
GO:0007519	IEA	-	skeletal muscle tissue development	-
GO:0007623	ISS	-	circadian rhythm	-
GO:0009887	IEA	-	animal organ morphogenesis	-
GO:0010506	TAS	-	regulation of autophagy	24852146
GO:0010742	IDA	-	macrophage derived foam cell differentiation	26504087
GO:0016032	IEA	-	viral process	-
GO:0016579	TAS	-	protein deubiquitination	-
GO:0018076	IDA	-	N-terminal peptidyl-lysine acetylation	12435739
GO:0018393	IDA	-	internal peptidyl-lysine acetylation	17403783
GO:0030183	IEA	-	B cell differentiation	-
GO:0030220	IEA	-	platelet formation	-
GO:0030324	IEA	-	lung development	-
GO:0032092	IEA	-	positive regulation of protein binding	-
GO:0032481	TAS	-	positive regulation of type I interferon production	-
GO:0034644	IDA	-	cellular response to UV	24939902
GO:0035855	IEA	-	megakaryocyte development	-
GO:0042771	IDA	-	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	17403783
GO:0043627	IDA	-	response to estrogen	11581164
GO:0043923	IDA	-	positive regulation by host of viral transcription	16687403
GO:0043967	IMP	-	histone H4 acetylation	16325578
GO:0043969	IDA	-	histone H2B acetylation	23415232
GO:0045444	ISS	-	fat cell differentiation	-
GO:0045815	TAS	-	positive regulation of gene expression, epigenetic	-
GO:0045944	IDA	-	positive regulation of transcription from RNA polymerase II promoter	12586840
GO:0045944	IMP	-	positive regulation of transcription from RNA polymerase II promoter	16325578
GO:0045944	TAS	-	positive regulation of transcription from RNA polymerase II promoter	-
GO:0050821	ISS	-	protein stabilization	-
GO:0051091	IDA	-	positive regulation of sequence-specific DNA binding transcription factor activity	10518217
GO:0051726	TAS	-	regulation of cell cycle	-
GO:0060765	IDA	-	regulation of androgen receptor signaling pathway	18487222
GO:0061418	TAS	-	regulation of transcription from RNA polymerase II promoter in response to hypoxia	-
GO:0090043	IDA	-	regulation of tubulin deacetylation	18722353
GO:1900034	TAS	-	regulation of cellular response to heat	-
GO:1901796	TAS	-	regulation of signal transduction by p53 class mediator	-
GO:1904837	TAS	-	beta-catenin-TCF complex assembly	-

Gene Symbol	Interactant	Interaction ID	References	Description
EP300	PARP1	108347	16204234 18280497 19622798	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
EP300	PARP1	106652	16204234 18280497 19622798	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
EP300	AKT1	108347	18182168	Affinity Capture-Western
EP300	AKT1	106710	18182168	Affinity Capture-Western
EP300	AR	108347	18487222	Affinity Capture-Western
EP300	AR	106862	18487222	Affinity Capture-Western
EP300	ARNTL	108347	14645221	Reconstituted Complex
EP300	ARNTL	106899	14645221	Reconstituted Complex
EP300	ASCL1	108347	11564735	Affinity Capture-Western
EP300	ASCL1	106921	11564735	Affinity Capture-Western
EP300	ATF4	106958	16219772	Affinity Capture-Western; Reconstituted Complex
EP300	ATF4	108347	16219772	Affinity Capture-Western; Reconstituted Complex
EP300	CCND1	108347	11788592	Reconstituted Complex
EP300	CCND1	107067	11788592	Reconstituted Complex
EP300	BCL3	108347	10497212	Reconstituted Complex; Two-hybrid
EP300	BCL3	107074	10497212	Reconstituted Complex; Two-hybrid
EP300	BCL6	107076	12402037	Affinity Capture-Western; Biochemical Activity
EP300	BCL6	108347	12402037	Affinity Capture-Western; Biochemical Activity
EP300	BRCA1	108347	10655477 11782371	Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
EP300	BRCA1	107140	10655477 11782371	Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex
EP300	KLF5	108347	14612398 15668237	Affinity Capture-Western; Reconstituted Complex
EP300	KLF5	107153	14612398 15668237	Affinity Capture-Western; Reconstituted Complex
EP300	RUNX2	108347	16613856 16728531	Affinity Capture-Western
EP300	RUNX2	107308	16613856 16728531	Affinity Capture-Western
EP300	RUNX1	108347	16917507	Affinity Capture-Western
EP300	RUNX1	107309	16917507	Affinity Capture-Western
EP300	RUNX3	108347	15138260	Affinity Capture-Western
EP300	RUNX3	107312	15138260	Affinity Capture-Western
EP300	CDC20	108347	16319895	Affinity Capture-Western
EP300	CDC20	107427	16319895	Affinity Capture-Western
EP300	CDH1	108347	16319895	Affinity Capture-Western
EP300	CDH1	107434	16319895	Affinity Capture-Western
EP300	CDKN1A	108347	18263614	Affinity Capture-Western; Reconstituted Complex
EP300	CDKN1A	107460	18263614	Affinity Capture-Western; Reconstituted Complex
EP300	CDX2	108347	10506141	Affinity Capture-Western; Reconstituted Complex
EP300	CDX2	107475	10506141	Affinity Capture-Western; Reconstituted Complex
EP300	CEBPA	108347	12861022	Phenotypic Enhancement
EP300	CEBPA	107479	12861022	Phenotypic Enhancement
EP300	CEBPB	108347	9343424	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
EP300	CEBPB	107480	9343424	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid

AutismKB 2.0

Annotation Details for EP300