AutismKB 2.0

Annotation Details for EPAS1


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Basic Information Top
Gene Symbol:EPAS1 ( ECYT4,HIF2A,HLF,MOP2,PASD2,bHLHe73 )
Gene Full Name: endothelial PAS domain protein 1
Band: 2p21
Quick LinksEntrez ID:2034; OMIM: 603349; Uniprot ID:EPAS1_HUMAN; ENSEMBL ID: ENSG00000116016; HGNC ID: 3374
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005654TAS-nucleoplasm-
GO:0005667IDA-transcription factor complex9000051
GO:0005667IPI-transcription factor complex9576906
GO:0005829TAS-cytosol-
GO:0016607IEA-nuclear speck-
GO ID Evidence Qualifier GO_term References
GO:0000981IBA-RNA polymerase II transcription factor activity, sequence-specific DNA binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003677IGI-DNA binding9000051
GO:0005515IPI-protein binding15231748
GO:0008134IPI-transcription factor binding9079689
GO:0035035IPI-histone acetyltransferase binding15261140
GO:0043565IDAcontributes_tosequence-specific DNA binding9079689
GO:0046982IPI-protein heterodimerization activity9079689
GO ID Evidence Qualifier GO_term References
GO:0001525IEA-angiogenesis-
GO:0001666IDA-response to hypoxia11782478
GO:0001892IEA-embryonic placenta development-
GO:0001974IEA-blood vessel remodeling-
GO:0002027IEA-regulation of heart rate-
GO:0006366TAS-transcription from RNA polymerase II promoter9079689
GO:0007005IEA-mitochondrion organization-
GO:0007165TAS-signal transduction9079689
GO:0007601IEA-visual perception-
GO:0016567TAS-protein ubiquitination-
GO:0030218IEA-erythrocyte differentiation-
GO:0030324IEA-lung development-
GO:0035019TAS-somatic stem cell population maintenance-
GO:0042415IEA-norepinephrine metabolic process-
GO:0043129IEA-surfactant homeostasis-
GO:0043619IEA-regulation of transcription from RNA polymerase II promoter in response to oxidative stress-
GO:0043687TAS-post-translational protein modification-
GO:0045944IDA-positive regulation of transcription from RNA polymerase II promoter11573933
GO:0045944IGI-positive regulation of transcription from RNA polymerase II promoter9000051
GO:0048469IEA-cell maturation-
GO:0048625ISS-myoblast fate commitment-
GO:0055072IEA-iron ion homeostasis-
GO:0061418TAS-regulation of transcription from RNA polymerase II promoter in response to hypoxia-
GO:0071456IDA-cellular response to hypoxia11573933
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
EPAS1APC10682120936779 Two-hybrid
EPAS1APC10834820936779 Two-hybrid
EPAS1ARNT1068989079689 Reconstituted Complex; Two-hybrid
EPAS1ARNT1083489079689 Reconstituted Complex; Two-hybrid
EPAS1ARNTL1083489576906 Reconstituted Complex; Two-hybrid
EPAS1ARNTL1068999576906 Reconstituted Complex; Two-hybrid
VHLEPAS110834812604794 17967880 Affinity Capture-Western
VHLEPAS111326912604794 17967880 Affinity Capture-Western
PSMC3EPAS110834814556007 Affinity Capture-Western
PSMC3EPAS111167514556007 Affinity Capture-Western
EGLN1EPAS110834816407130 Reconstituted Complex
EGLN1EPAS112006016407130 Reconstituted Complex
MAXEPAS110834817418410 Affinity Capture-Western
MAXEPAS111031917418410 Affinity Capture-Western
ARNT2EPAS110834820211142 Two-hybrid
ARNT2EPAS111524420211142 Two-hybrid
MEF2CEPAS111037220936779 Two-hybrid
MEF2CEPAS110834820936779 Two-hybrid
Gene Symbol Interactant Interaction ID References Description
EPAS1ARNT1931729113979 HLF interacts with Arnt. This interaction was modeled on a demonstrated interaction between mouse HLF and human Arnt.
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:109169
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-4490'