AutismKB 2.0

Annotation Details for ERBB4


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Basic Information Top
Gene Symbol:ERBB4 ( HER4,MGC138404,p180erbB4 )
Gene Full Name: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Band: 2q34
Quick LinksEntrez ID:2066; OMIM: 600543; Uniprot ID:ERBB4_HUMAN; ENSEMBL ID: ENSG00000178568; HGNC ID: 3432
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576TAS-extracellular region-
GO:0005634IDA-nucleus15534001
GO:0005654TAS-nucleoplasm-
GO:0005739IDA-mitochondrion16778220
GO:0005759TAS-mitochondrial matrix-
GO:0005829TAS-cytosol-
GO:0005886TAS-plasma membrane-
GO:0016021IEA-integral component of membrane-
GO:0016323IDA-basolateral plasma membrane12646923
GO:0043235IDA-receptor complex23382219
GO ID Evidence Qualifier GO_term References
GO:0004713IDA-protein tyrosine kinase activity18334220
GO:0004713TAS-protein tyrosine kinase activity-
GO:0004714IDA-transmembrane receptor protein tyrosine kinase activity18334220
GO:0004716IEA-signal transducer, downstream of receptor, with protein tyrosine kinase activity-
GO:0005088TAS-Ras guanyl-nucleotide exchange factor activity-
GO:0005154IPI-epidermal growth factor receptor binding8617750
GO:0005515IPI-protein binding9419975
GO:0005524IEA-ATP binding-
GO:0042803IPI-protein homodimerization activity18334220
GO:0044212IMP-transcription regulatory region DNA binding15534001
GO:0046934TAS-phosphatidylinositol-4,5-bisphosphate 3-kinase activity-
GO ID Evidence Qualifier GO_term References
GO:0000165TAS-MAPK cascade-
GO:0001755ISS-neural crest cell migration-
GO:0001934TAS-positive regulation of protein phosphorylation15534001
GO:0006351IEA-transcription, DNA-templated-
GO:0007165IDA-signal transduction10572067
GO:0007169IDA-transmembrane receptor protein tyrosine kinase signaling pathway10353604
GO:0007399ISS-nervous system development-
GO:0007507ISS-heart development-
GO:0007595IMP-lactation15534001
GO:0008283TAS-cell proliferation8383326
GO:0008284IMP-positive regulation of cell proliferation8617750
GO:0008285IMP-negative regulation of cell proliferation17120616
GO:0009880ISS-embryonic pattern specification-
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0014068IEA-positive regulation of phosphatidylinositol 3-kinase signaling-
GO:0016477IDA-cell migration9135143
GO:0018108IDA-peptidyl-tyrosine phosphorylation18334220
GO:0021551ISS-central nervous system morphogenesis-
GO:0021889ISS-olfactory bulb interneuron differentiation-
GO:0030334ISS-regulation of cell migration-
GO:0038083IEA-peptidyl-tyrosine autophosphorylation-
GO:0038128TAS-ERBB2 signaling pathway-
GO:0042531IMP-positive regulation of tyrosine phosphorylation of STAT protein16837552
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043066IEA-negative regulation of apoptotic process-
GO:0043547IEA-positive regulation of GTPase activity-
GO:0043653IMP-mitochondrial fragmentation involved in apoptotic process16778220
GO:0045165IEA-cell fate commitment-
GO:0045893IMP-positive regulation of transcription, DNA-templated15534001
GO:0046777IDA-protein autophosphorylation18334220
GO:0046854IEA-phosphatidylinositol phosphorylation-
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0060045ISS-positive regulation of cardiac muscle cell proliferation-
GO:0060644ISS-mammary gland epithelial cell differentiation-
GO:0060749ISS-mammary gland alveolus development-
GO:0061026ISS-cardiac muscle tissue regeneration-
GO:0070374IMP-positive regulation of ERK1 and ERK2 cascade10348342
GO:0071364IEA-cellular response to epidermal growth factor stimulus-
GO:1901185TAS-negative regulation of ERBB signaling pathway-
GO:2000010IEA-positive regulation of protein localization to cell surface-
GO:2000145TAS-regulation of cell motility-
GO:2000366IMP-positive regulation of STAT protein import into nucleus15534001
GO:2001223IEA-negative regulation of neuron migration-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ERBB4CD4410739811825873 Affinity Capture-Western
ERBB4CD4410837811825873 Affinity Capture-Western
ERBB4CRK10778816729043 Affinity Capture-MS
ERBB4CRK10837816729043 Affinity Capture-MS
ERBB4DLG110808312175853 Affinity Capture-Western
ERBB4DLG110837812175853 Affinity Capture-Western
ERBB4DLG210808410725395 Two-hybrid
ERBB4DLG210837810725395 Two-hybrid
ERBB4DLG310808510725395 Two-hybrid
ERBB4DLG310837810725395 Two-hybrid
ERBB4DLG410808610725395 10839362 Affinity Capture-Western; Co-fractionation; Two-hybrid
ERBB4DLG410837810725395 10839362 Affinity Capture-Western; Co-fractionation; Two-hybrid
ERBB4ERBB210837610839362 Affinity Capture-Western
ERBB4ERBB210837810839362 Affinity Capture-Western
NRG1ERBB41093329168115 Reconstituted Complex
NRG1ERBB41083789168115 Reconstituted Complex
NRG2ERBB41149179168115 Reconstituted Complex
NRG2ERBB41083789168115 Reconstituted Complex
EREGERBB41083819419975 Affinity Capture-Luminescence
EREGERBB41083789419975 Affinity Capture-Luminescence
SNTB2ERBB411252810725395 Two-hybrid
SNTB2ERBB410837810725395 Two-hybrid
MUC1ERBB411066911278868 Affinity Capture-Western
MUC1ERBB410837811278868 Affinity Capture-Western
RNF41ERBB411548811867753 Reconstituted Complex
RNF41ERBB410837811867753 Reconstituted Complex
YAP1ERBB411568415023535 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
YAP1ERBB410837815023535 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
LRIG1ERBB411748915282549 15345710 Affinity Capture-Western
LRIG1ERBB410837815282549 15345710 Affinity Capture-Western
UBCERBB411316415345710 17463226 18334649 Affinity Capture-Western
UBCERBB410837815345710 17463226 18334649 Affinity Capture-Western
STAT5AERBB411265315534001 16729043 Affinity Capture-MS; Affinity Capture-Western
STAT5AERBB410837815534001 16729043 Affinity Capture-MS; Affinity Capture-Western
GRB2ERBB410914216729043 Affinity Capture-MS
GRB2ERBB410837816729043 Affinity Capture-MS
NCK1ERBB411077016729043 Affinity Capture-MS
NCK1ERBB410837816729043 Affinity Capture-MS
PIK3R2ERBB411131416729043 Affinity Capture-MS
PIK3R2ERBB410837816729043 Affinity Capture-MS
PTPN11ERBB411174516729043 Affinity Capture-MS
PTPN11ERBB410837816729043 Affinity Capture-MS
SHC1ERBB411236116729043 Affinity Capture-MS
SHC1ERBB410837816729043 Affinity Capture-MS
ITCHERBB412374717463226 18334649 Affinity Capture-Western; Far Western; Reconstituted Complex
ITCHERBB410837817463226 18334649 Affinity Capture-Western; Far Western; Reconstituted Complex
HDAC6ERBB411533020029029 PCA
HDAC6ERBB410837820029029 PCA
Gene Symbol Interactant Interaction ID References Description
ERBB4DLG214976110725395 ErbB-4 interacts with CHAPSYN-110.
No data
AlzGene, PDGene and SZGene Top
No data
No data
Gene Symbol Poly Names Gene overview in SZGene
ERBB4ERBB4_3228A>G, ERBB4_IVS10+60C>T, ERBB4_IVS12-15C>T, ERBB4_IVS16+23T>C, ERBB4_IVS16-24[A], ERBB4_IVS17-102[G], ERBB4_IVS2+67G>C, ERBB4_IVS20-50G>A, ERBB4_IVS25+63A>G, ERBB4_IVS25-92C>T, ERBB4_IVS3+58A>G, ERBB4_IVS5-67A>G, rs-GSK8116805, rs10164682, rs10166403, rs10166993, rs10167304, rs10172563, rs10172698, rs10173674, rs10175273, rs10176489, rs10180494, rs10184205, rs10190653, rs10198466, rs10200047, rs10201617, rs10205553, rs1026882, rs10497945, rs10497947, rs10497952, rs10497965, rs10932390, rs11679499, rs11891107, rs12052288, rs12475812, rs12478950, rs12623444, rs1351593, rs1357137, rs1357139, rs1357142, rs1384292, rs1394781, rs1394795, rs1394796, rs1482378, rs1482381, rs1505345, rs1505368, rs1505377, rs1521537, rs1521542, rs1521546, rs1521642, rs1521654, rs1521657, rs1521661, rs1595066, rs16846873, rs16846896, rs1816532, rs1836720, rs1836724, rs1836750, rs1851169, rs1851185, rs1851194, rs1851196, rs1879635, rs1905139, rs1910866, rs1915745, rs1948875, rs1976834, rs2030474, rs2054617, rs2062930, rs2062937, rs2135155, rs2170529, rs2272024, rs2289086, rs2371275, rs2371276, rs2371277, rs2371312, rs2371439, rs2371476, rs2371481, rs2579980, rs2888051, rs3748952, rs3748962, rs3791682, rs3791702, rs3791703, rs3791707, rs3791709, rs3923755, rs4132462, rs4145961, rs4292044, rs4404216, rs4411644, rs4500888, rs4539738, rs4597456, rs4599046, rs4627509, rs4672620, rs4672635, rs4672643, rs4673615, rs4673628, rs4673629, rs4673659, rs6435659, rs6435660, rs6435661, rs6435665, rs6435670, rs6435671, rs6435675, rs6435706, rs6435711, rs6435870, rs6705698, rs6706010, rs6711487, rs6719664, rs6725181, rs6726567, rs6727114, rs6727447, rs6729362, rs6730119, rs6731193, rs6731471, rs6734634, rs6738304, rs6743565, rs6743763, rs6745717, rs6749448, rs6752616, rs6754674, rs6758038, rs707284, rs7419259, rs7419602, rs7421820, rs7422774, rs7422996, rs7423708, rs7424835, rs7425341, rs7425448, rs7426206, rs7560730, rs7564771, rs7565192, rs7568740, rs7571561, rs7582903, rs7588431, rs7588440, rs7592809, rs7593315, rs7595439, rs7596285, rs7597007, rs7598440, rs7599312, rs839504, rs839513, rs839519, rs839523, rs839530, rs839533, rs839541, rs9288435, rs9288436, rs9288438, rs939223, rs9653257, rs979042, rs987320, rs991495 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:104771
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030918-4'