AutismKB 2.0

Annotation Details for AKT1


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Basic Information Top
Gene Symbol:AKT1 ( AKT,MGC99656,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA )
Gene Full Name: v-akt murine thymoma viral oncogene homolog 1
Band: 14q32.33
Quick LinksEntrez ID:207; OMIM: 164730; Uniprot ID:AKT1_HUMAN; ENSEMBL ID: ENSG00000142208; HGNC ID: 391
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005634IDA-nucleus20333297
GO:0005634TAS-nucleus21432781
GO:0005654TAS-nucleoplasm-
GO:0005737IDA-cytoplasm19203586
GO:0005737ISS-cytoplasm-
GO:0005737TAS-cytoplasm21432781
GO:0005739IEA-mitochondrion-
GO:0005819IEA-spindle-
GO:0005829IDA-cytosol21045808
GO:0005829TAS-cytosol-
GO:0005886IDA-plasma membrane14749367
GO:0005886TAS-plasma membrane21432781
GO:0005911IEA-cell-cell junction-
GO:0015630IDA-microtubule cytoskeleton-
GO:0031982IDA-vesicle16792529
GO:0036064IEA-ciliary basal body-
GO:0043234IEA-protein complex-
GO:0098794IEA-postsynapse-
GO ID Evidence Qualifier GO_term References
GO:0004672TAS-protein kinase activity10570282
GO:0004674EXP-protein serine/threonine kinase activity17030608
GO:0004674IDA-protein serine/threonine kinase activity10102273
GO:0004674TAS-protein serine/threonine kinase activity21432781
GO:0004712IDA-protein serine/threonine/tyrosine kinase activity22797923
GO:0005080IEA-protein kinase C binding-
GO:0005515IPI-protein binding11154276
GO:0005524IC-ATP binding11994271
GO:0005524IDA-ATP binding16540465
GO:0005547IDA-phosphatidylinositol-3,4,5-trisphosphate binding19203586
GO:0016301IDA-kinase activity14749367
GO:0019899ISS-enzyme binding-
GO:0030235IMP-nitric-oxide synthase regulator activity10376603
GO:0032794IEA-GTPase activating protein binding-
GO:0042802IPI-identical protein binding7891724
GO:0043325IDA-phosphatidylinositol-3,4-bisphosphate binding19203586
GO:0051721IEA-protein phosphatase 2A binding-
GO:0071889IPI-14-3-3 protein binding10102273
GO ID Evidence Qualifier GO_term References
GO:0000060IMP-protein import into nucleus, translocation16280327
GO:0000082TAS-G1/S transition of mitotic cell cycle-
GO:0001649IEA-osteoblast differentiation-
GO:0001893IEA-maternal placenta development-
GO:0001934IDA-positive regulation of protein phosphorylation19057511
GO:0001938IMP-positive regulation of endothelial cell proliferation19850054
GO:0005978IEA-glycogen biosynthetic process-
GO:0005979IMP-regulation of glycogen biosynthetic process8940145
GO:0006006IEA-glucose metabolic process-
GO:0006412IEA-translation-
GO:0006417IEA-regulation of translation-
GO:0006464TAS-cellular protein modification process10570282
GO:0006468IDA-protein phosphorylation11994271
GO:0006469IMP-negative regulation of protein kinase activity9373175
GO:0006469ISS-negative regulation of protein kinase activity-
GO:0006809TAS-nitric oxide biosynthetic process10376602
GO:0006924IMP-activation-induced cell death of T cells14749367
GO:0006954IEA-inflammatory response-
GO:0006974IEA-cellular response to DNA damage stimulus-
GO:0006979ISS-response to oxidative stress-
GO:0007165TAS-signal transduction21432781
GO:0007186TAS-G-protein coupled receptor signaling pathway10570282
GO:0007249IMP-I-kappaB kinase/NF-kappaB signaling26514923
GO:0007281IEA-germ cell development-
GO:0007568IEA-aging-
GO:0008283TAS-cell proliferation21432781
GO:0008286IMP-insulin receptor signaling pathway8978681
GO:0008637IEA-apoptotic mitochondrial changes-
GO:0009408TAS-response to heat10958679
GO:0010507IMP-negative regulation of autophagy18387192
GO:0010629IEA-negative regulation of gene expression-
GO:0010748IMP-negative regulation of plasma membrane long-chain fatty acid transport16814735
GO:0010763IEA-positive regulation of fibroblast migration-
GO:0010765IEA-positive regulation of sodium ion transport-
GO:0010907IMP-positive regulation of glucose metabolic process16814735
GO:0010951IMP-negative regulation of endopeptidase activity18387192
GO:0010975ISS-regulation of neuron projection development-
GO:0014065IMP-phosphatidylinositol 3-kinase signaling26514923
GO:0014066TAS-regulation of phosphatidylinositol 3-kinase signaling-
GO:0015758IEA-glucose transport-
GO:0016242NAS-negative regulation of macroautophagy23778976
GO:0016310IDA-phosphorylation20333297
GO:0016567IEA-protein ubiquitination-
GO:0018105IDA-peptidyl-serine phosphorylation16139227
GO:0018105TAS-peptidyl-serine phosphorylation21711983
GO:0018107IDA-peptidyl-threonine phosphorylation20605787
GO:0021510IEA-spinal cord development-
GO:0030030IEA-cell projection organization-
GO:0030154TAS-cell differentiation21432781
GO:0030163IEA-protein catabolic process-
GO:0030168TAS-platelet activation-
GO:0030212IEA-hyaluronan metabolic process-
GO:0030307IDA-positive regulation of cell growth19203586
GO:0030334IMP-regulation of cell migration19934221
GO:0030334TAS-regulation of cell migration21432781
GO:0031018TAS-endocrine pancreas development-
GO:0031295TAS-T cell costimulation-
GO:0031641IEA-regulation of myelination-
GO:0031659IDA-positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle18483258
GO:0031663IEA-lipopolysaccharide-mediated signaling pathway-
GO:0031929NAS-TOR signaling23778976
GO:0031999IMP-negative regulation of fatty acid beta-oxidation16814735
GO:0032079IDA-positive regulation of endodeoxyribonuclease activity20605787
GO:0032094IEA-response to food-
GO:0032270ISS-positive regulation of cellular protein metabolic process-
GO:0032287IEA-peripheral nervous system myelin maintenance-
GO:0032436IEA-positive regulation of proteasomal ubiquitin-dependent protein catabolic process-
GO:0032869IMP-cellular response to insulin stimulus16814735
GO:0032869ISS-cellular response to insulin stimulus-
GO:0033138IDA-positive regulation of peptidyl-serine phosphorylation19667065
GO:0034405IMP-response to fluid shear stress10376603
GO:0034614IMP-cellular response to reactive oxygen species26514923
GO:0035556IDA-intracellular signal transduction14749367
GO:0035655IDA-interleukin-18-mediated signaling pathway21321938
GO:0035924IEA-cellular response to vascular endothelial growth factor stimulus-
GO:0038061IMP-NIK/NF-kappaB signaling26514923
GO:0042593IEA-glucose homeostasis-
GO:0043065IEA-positive regulation of apoptotic process-
GO:0043066IDA-negative regulation of apoptotic process19203586
GO:0043154ISS-negative regulation of cysteine-type endopeptidase activity involved in apoptotic process-
GO:0043276NAS-anoikis23778976
GO:0043488TAS-regulation of mRNA stability-
GO:0043491IEA-protein kinase B signaling-
GO:0043536IDA-positive regulation of blood vessel endothelial cell migration20011604
GO:0045429IMP-positive regulation of nitric oxide biosynthetic process10376603
GO:0045600IMP-positive regulation of fat cell differentiation8940145
GO:0045725IMP-positive regulation of glycogen biosynthetic process16814735
GO:0045725NAS-positive regulation of glycogen biosynthetic process17925406
GO:0045742TAS-positive regulation of epidermal growth factor receptor signaling pathway-
GO:0045792IEA-negative regulation of cell size-
GO:0045861IMP-negative regulation of proteolysis18387192
GO:0045893IMP-positive regulation of transcription, DNA-templated26514923
GO:0045907IEA-positive regulation of vasoconstriction-
GO:0045944IEA-positive regulation of transcription from RNA polymerase II promoter-
GO:0046326IMP-positive regulation of glucose import8940145
GO:0046329IEA-negative regulation of JNK cascade-
GO:0046622IEA-positive regulation of organ growth-
GO:0046777TAS-protein autophosphorylation16280327
GO:0046889IMP-positive regulation of lipid biosynthetic process8940145
GO:0048009IMP-insulin-like growth factor receptor signaling pathway8978681
GO:0048015TAS-phosphatidylinositol-mediated signaling-
GO:0048661IDA-positive regulation of smooth muscle cell proliferation21321938
GO:0050999TAS-regulation of nitric-oxide synthase activity-
GO:0051000IMP-positive regulation of nitric-oxide synthase activity10376603
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity19057511
GO:0051146IEA-striated muscle cell differentiation-
GO:0060416ISS-response to growth hormone-
GO:0060644TAS-mammary gland epithelial cell differentiation21432781
GO:0060709IEA-glycogen cell differentiation involved in embryonic placenta development-
GO:0060716IEA-labyrinthine layer blood vessel development-
GO:0061024TAS-membrane organization-
GO:0070141IDA-response to UV-A18483258
GO:0071260IEA-cellular response to mechanical stimulus-
GO:0071276IMP-cellular response to cadmium ion26514923
GO:0071364IEA-cellular response to epidermal growth factor stimulus-
GO:0071380IEA-cellular response to prostaglandin E stimulus-
GO:0071407IEA-cellular response to organic cyclic compound-
GO:0071456IEA-cellular response to hypoxia-
GO:0072655IMP-establishment of protein localization to mitochondrion23962723
GO:0072656IMP-maintenance of protein location in mitochondrion23962723
GO:0090004IMP-positive regulation of establishment of protein localization to plasma membrane8940145
GO:0090201ISS-negative regulation of release of cytochrome c from mitochondria-
GO:0097011IEA-cellular response to granulocyte macrophage colony-stimulating factor stimulus-
GO:0097194IEA-execution phase of apoptosis-
GO:0099565NAS-chemical synaptic transmission, postsynaptic21711983
GO:0100002TAS-negative regulation of protein kinase activity by protein phosphorylation21711983
GO:1900182IMP-positive regulation of protein localization to nucleus20605787
GO:1901215NAS-negative regulation of neuron death18221368
GO:1901796TAS-regulation of signal transduction by p53 class mediator-
GO:1901976TAS-regulation of cell cycle checkpoint21432781
GO:1902176NAS-negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway16604263
GO:1903721IMP-positive regulation of I-kappaB phosphorylation26514923
GO:1990090IMP-cellular response to nerve growth factor stimulus20605787
GO:1990418ISS-response to insulin-like growth factor stimulus-
GO:2001240TAS-negative regulation of extrinsic apoptotic signaling pathway in absence of ligand10748004
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
AKT1ACTA110657316568092 Affinity Capture-Western
AKT1ACTA110671016568092 Affinity Capture-Western
ARFIP2AKT11171749312003 Two-hybrid
ARFIP2AKT11067109312003 Two-hybrid
ILKAKT11098249736715 11313365 11825911 Affinity Capture-Western; Biochemical Activity
ILKAKT11067109736715 11313365 11825911 Affinity Capture-Western; Biochemical Activity
PRKCZAKT111157610085094 Affinity Capture-Western
PRKCZAKT110671010085094 Affinity Capture-Western
CHUKAKT110671010485710 10485711 15800029 Affinity Capture-Western; Biochemical Activity
CHUKAKT110756910485710 10485711 15800029 Affinity Capture-Western; Biochemical Activity
IRS1AKT110987410497255 Affinity Capture-Western
IRS1AKT110671010497255 Affinity Capture-Western
BRCA1AKT110671010542266 19074868 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BRCA1AKT110714010542266 19074868 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
RAF1AKT110671010576742 Affinity Capture-Western; Biochemical Activity
RAF1AKT111183110576742 Affinity Capture-Western; Biochemical Activity
BRAFAKT110671010869359 Affinity Capture-Western; Biochemical Activity
BRAFAKT110714110869359 Affinity Capture-Western; Biochemical Activity
MTORAKT110671010910062 14970221 15718470 Protein-peptide; Reconstituted Complex
MTORAKT110875710910062 14970221 15718470 Protein-peptide; Reconstituted Complex
PKN2AKT110671010926925 Affinity Capture-Western; Two-hybrid
PKN2AKT111157210926925 Affinity Capture-Western; Two-hybrid
IMPDH2AKT110982810930578 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
IMPDH2AKT110671010930578 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MTCP1AKT111061810983986 11707444 Affinity Capture-Western
MTCP1AKT110671010983986 11707444 Affinity Capture-Western
TCL1BAKT111498310983986 Affinity Capture-Western
TCL1BAKT110671010983986 Affinity Capture-Western
TCL1AAKT111378310983986 11707444 12009899 Affinity Capture-Western; Reconstituted Complex
TCL1AAKT110671010983986 11707444 12009899 Affinity Capture-Western; Reconstituted Complex
HSP90AA1AKT110955210995457 12176997 12586360 15843522 Affinity Capture-Western
HSP90AA1AKT110671010995457 12176997 12586360 15843522 Affinity Capture-Western
HSP90AB1AKT110955810995457 Affinity Capture-Western
HSP90AB1AKT110671010995457 Affinity Capture-Western
HSPB1AKT110671011042204 Affinity Capture-Western
HSPB1AKT110954711042204 Affinity Capture-Western
MAPKAPK2AKT111468311042204 Affinity Capture-Western
MAPKAPK2AKT110671011042204 Affinity Capture-Western
MAPK14AKT110671011042204 Affinity Capture-Western; Biochemical Activity
MAPK14AKT110781911042204 Affinity Capture-Western; Biochemical Activity
KTN1AKT110671011162552 Two-hybrid
KTN1AKT111009211162552 Two-hybrid
NR4A1AKT110671011274386 Affinity Capture-Western; Biochemical Activity
NR4A1AKT110940711274386 Affinity Capture-Western; Biochemical Activity
CHN2AKT110671011278894 Reconstituted Complex
CHN2AKT110754811278894 Reconstituted Complex
PDPK1AKT111119611313365 11825911 Affinity Capture-Western
PDPK1AKT110671011313365 11825911 Affinity Capture-Western
ARAKT110671011404460 Affinity Capture-Western; Reconstituted Complex
ARAKT110686211404460 Affinity Capture-Western; Reconstituted Complex
PRKCQAKT111157411410591 Affinity Capture-Western; Reconstituted Complex
PRKCQAKT110671011410591 Affinity Capture-Western; Reconstituted Complex
BADAKT110671011500364 Reconstituted Complex
BADAKT110704811500364 Reconstituted Complex
KRT10AKT111005611585925 Affinity Capture-Western; Two-hybrid
KRT10AKT110671011585925 Affinity Capture-Western; Two-hybrid
THEM4AKT110671011598301 Affinity Capture-Western
THEM4AKT112555711598301 Affinity Capture-Western
MAP2K4AKT110671011707464 Affinity Capture-Western; Biochemical Activity
MAP2K4AKT111231511707464 Affinity Capture-Western; Biochemical Activity
MDM2AKT110671011715018 11923280 12145204 Affinity Capture-Western; Biochemical Activity
MDM2AKT111035811715018 11923280 12145204 Affinity Capture-Western; Biochemical Activity
PAK6AKT112125111773441 Reconstituted Complex
PAK6AKT110671011773441 Reconstituted Complex
GAB2AKT110671011782427 Affinity Capture-Western; Biochemical Activity
GAB2AKT111518111782427 Affinity Capture-Western; Biochemical Activity
UBCAKT111316411923280 12750378 18292230 Affinity Capture-Western
UBCAKT110671011923280 12750378 18292230 Affinity Capture-Western
YWHAZAKT111336611956222 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
YWHAZAKT110671011956222 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
IRAK1AKT110986311976320 Affinity Capture-Western
IRAK1AKT110671011976320 Affinity Capture-Western
CDKN1BAKT110746112042314 Affinity Capture-Western; Biochemical Activity
CDKN1BAKT110671012042314 Affinity Capture-Western; Biochemical Activity
MAP3K8AKT110671012138205 Affinity Capture-Western; Biochemical Activity
MAP3K8AKT110771912138205 Affinity Capture-Western; Biochemical Activity
TSC1AKT111309912167664 15342917 Affinity Capture-Western
TSC1AKT110671012167664 15342917 Affinity Capture-Western
TSC2AKT111310012167664 15342917 Affinity Capture-Western; Reconstituted Complex
TSC2AKT110671012167664 15342917 Affinity Capture-Western; Reconstituted Complex
CDC37AKT111631212176997 Affinity Capture-Western
CDC37AKT110671012176997 Affinity Capture-Western
MAPK8IP1AKT111486412194869 Affinity Capture-Western
MAPK8IP1AKT110671012194869 Affinity Capture-Western
ARHGAP32AKT111509112446789 Biochemical Activity
ARHGAP32AKT110671012446789 Biochemical Activity
MAP3K11AKT111044212458207 Affinity Capture-Western; Reconstituted Complex
MAP3K11AKT110671012458207 Affinity Capture-Western; Reconstituted Complex
HSPA4AKT110671012750378 Affinity Capture-Western
HSPA4AKT110954012750378 Affinity Capture-Western
TRIB3AKT112175612791994 Affinity Capture-Western; Reconstituted Complex
TRIB3AKT110671012791994 Affinity Capture-Western; Reconstituted Complex
FANCAAKT110671014499622 Two-hybrid
FANCAAKT110847214499622 Two-hybrid
XIAPAKT110682814645242 Affinity Capture-Western; Biochemical Activity
XIAPAKT110671014645242 Affinity Capture-Western; Biochemical Activity
AKTIPAKT112215714749367 Affinity Capture-Western; Reconstituted Complex
AKTIPAKT110671014749367 Affinity Capture-Western; Reconstituted Complex
ARHGAP29AKT110671014749388 Two-hybrid
ARHGAP29AKT111480614749388 Two-hybrid
PAK1AKT110671014749719 Reconstituted Complex
PAK1AKT111109514749719 Reconstituted Complex
RPS6KB1AKT111211215149849 Co-purification
RPS6KB1AKT110671015149849 Co-purification
PLXNA1AKT110671015187088 Reconstituted Complex; Two-hybrid
PLXNA1AKT111137515187088 Reconstituted Complex; Two-hybrid
RICTORAKT112896215718470 Reconstituted Complex
RICTORAKT110671015718470 Reconstituted Complex
TERTAKT111287415843522 Affinity Capture-Western
TERTAKT110671015843522 Affinity Capture-Western
IKBKBAKT110976715856005 Affinity Capture-Western
IKBKBAKT110671015856005 Affinity Capture-Western
CARHSP1AKT110671015910284 Reconstituted Complex
CARHSP1AKT111712415910284 Reconstituted Complex
GSK3BAKT110671016009706 Reconstituted Complex
GSK3BAKT110918716009706 Reconstituted Complex
FOXO1AKT110671016076959 Biochemical Activity
FOXO1AKT110859716076959 Biochemical Activity
PPA1AKT110671016186112 Affinity Capture-Western
PPA1AKT111146016186112 Affinity Capture-Western
EZH2AKT110671016224021 Affinity Capture-Western; Biochemical Activity
EZH2AKT110844616224021 Affinity Capture-Western; Biochemical Activity
SMAD2AKT110671016362038 Affinity Capture-Western
SMAD2AKT111026216362038 Affinity Capture-Western
SMAD3AKT110671016362038 Affinity Capture-Western
SMAD3AKT111026316362038 Affinity Capture-Western
SMAD4AKT110671016362038 Affinity Capture-Western
SMAD4AKT111026416362038 Affinity Capture-Western
SMAD7AKT111026716362038 Affinity Capture-Western
SMAD7AKT110671016362038 Affinity Capture-Western
SMARCC2AKT111248516568092 Affinity Capture-Western
SMARCC2AKT110671016568092 Affinity Capture-Western
SMARCB1AKT110671016568092 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SMARCB1AKT111248216568092 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SMARCC1AKT110671016568092 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
SMARCC1AKT111248316568092 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
NCOR2AKT111497416613989 Biochemical Activity; Reconstituted Complex
NCOR2AKT110671016613989 Biochemical Activity; Reconstituted Complex
MAPKAP1AKT112255116962653 Affinity Capture-Western
MAPKAP1AKT110671016962653 Affinity Capture-Western
USP8AKT111455517210635 Affinity Capture-Western
USP8AKT110671017210635 Affinity Capture-Western
PIAS1AKT111412417533377 Two-hybrid
PIAS1AKT110671017533377 Two-hybrid
PIAS2AKT111452317533377 Two-hybrid
PIAS2AKT110671017533377 Two-hybrid
NF2AKT110671017891137 Affinity Capture-Western; Reconstituted Complex
NF2AKT111084417891137 Affinity Capture-Western; Reconstituted Complex
EP300AKT110834718182168 Affinity Capture-Western
EP300AKT110671018182168 Affinity Capture-Western
STUB1AKT110671018292230 Affinity Capture-Western
STUB1AKT111556318292230 Affinity Capture-Western
MARK2AKT110671018292230 Affinity Capture-Western
MARK2AKT110832618292230 Affinity Capture-Western
NOTCH1AKT111091318440314 Biochemical Activity
NOTCH1AKT110671018440314 Biochemical Activity
NPM1AKT110671018931307 Affinity Capture-Western; Reconstituted Complex
NPM1AKT111092918931307 Affinity Capture-Western; Reconstituted Complex
MXD1AKT110671019526459 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
MXD1AKT111025919526459 Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
PLXNB1AKT110671019805522 Affinity Capture-Western
PLXNB1AKT111137719805522 Affinity Capture-Western
HDAC3AKT111436820026773 Affinity Capture-Western
HDAC3AKT110671020026773 Affinity Capture-Western
IKBKGAKT111408920098747 Reconstituted Complex
IKBKGAKT110671020098747 Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
No data
Gene Symbol Poly Names Gene overview in PDGene
AKT1rs1130214, rs2494738, rs2494743, rs2494746, rs2494750, rs2498788, rs3803304 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
AKT1D14S260, rs10149779, rs1130214, rs1130233, rs11847866, rs2494731, rs2494732, rs2494734, rs2494738, rs2494743, rs2494746, rs2494747, rs2494750, rs2494752, rs2498784, rs2498794, rs2498796, rs2498802, rs2498804, rs3001371, rs3730344, rs3730358, rs3803300, rs3803304, rs8192700 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:87986
  • Data Attributes: MGI curated and HomoloGene calculated
No data