AutismKB 2.0

Annotation Details for ERCC4


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Basic Information Top
Gene Symbol:ERCC4 ( ERCC11,RAD1,XPF )
Gene Full Name: excision repair cross-complementing rodent repair deficiency, complementation group 4
Band: 16p13.12
Quick LinksEntrez ID:2072; OMIM: 133520; Uniprot ID:XPF_HUMAN; ENSEMBL ID: ENSG00000175595; HGNC ID: 3436
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000109IDA-nucleotide-excision repair complex10644440
GO:0000110IDA-nucleotide-excision repair factor 1 complex10413517
GO:0000781IDA-chromosome, telomeric region14690602
GO:0000784IDA-nuclear chromosome, telomeric region14690602
GO:0005634IDA-nucleus12571280
GO:0005654TAS-nucleoplasm-
GO:0005669IEA-transcription factor TFIID complex-
GO:0070522IDA-ERCC4-ERCC1 complex14690602
GO ID Evidence Qualifier GO_term References
GO:0000014IBA-single-stranded DNA endodeoxyribonuclease activity-
GO:0001094IEA-TFIID-class transcription factor binding-
GO:0003677IDAcontributes_toDNA binding14734547
GO:0003684IMP-damaged DNA binding11790111
GO:0003697IDA-single-stranded DNA binding10413517
GO:0004520IDA-endodeoxyribonuclease activity10413517
GO:0004520IDAcontributes_toendodeoxyribonuclease activity8797827
GO:0004520IMP-endodeoxyribonuclease activity17055345
GO:0005515IPI-protein binding7559382
GO:0008022IPI-protein C-terminus binding9722633
GO:0010521IDANOTtelomerase inhibitor activity18812185
GO:0047485IPI-protein N-terminus binding14734547
GO:1990599IMPcontributes_to3' overhang single-stranded DNA endodeoxyribonuclease activity14690602
GO ID Evidence Qualifier GO_term References
GO:0000712IBA-resolution of meiotic recombination intermediates-
GO:0000723IGI-telomere maintenance17055345
GO:0000723IMP-telomere maintenance14690602
GO:0000724IMP-double-strand break repair via homologous recombination14728600
GO:0006281IGI-DNA repair17055345
GO:0006281IMP-DNA repair19596235
GO:0006283TAS-transcription-coupled nucleotide-excision repair-
GO:0006289IDA-nucleotide-excision repair10644440
GO:0006289IMP-nucleotide-excision repair8797827
GO:0006293TAS-nucleotide-excision repair, preincision complex stabilization-
GO:0006295IMP-nucleotide-excision repair, DNA incision, 3'-to lesion11790111
GO:0006295TAS-nucleotide-excision repair, DNA incision, 3'-to lesion-
GO:0006296IMP-nucleotide-excision repair, DNA incision, 5'-to lesion11790111
GO:0006296TAS-nucleotide-excision repair, DNA incision, 5'-to lesion-
GO:0006303IMP-double-strand break repair via nonhomologous end joining14690602
GO:0009411IMP-response to UV16678501
GO:0009650IEA-UV protection-
GO:0032205IMP-negative regulation of telomere maintenance17055345
GO:0033683IDA-nucleotide-excision repair, DNA incision10413517
GO:0033683TAS-nucleotide-excision repair, DNA incision-
GO:0034644IGI-cellular response to UV17055345
GO:0036297TAS-interstrand cross-link repair-
GO:0051974IDANOTnegative regulation of telomerase activity18812185
GO:0061819IMP-telomeric DNA-containing double minutes formation14690602
GO:0070911TAS-global genome nucleotide-excision repair-
GO:1901255IBA-nucleotide-excision repair involved in interstrand cross-link repair-
GO:1904357IDA-negative regulation of telomere maintenance via telomere lengthening18812185
GO:1905765IMP-negative regulation of protection from non-homologous end joining at telomere14690602
GO:1905768IDA-negative regulation of double-stranded telomeric DNA binding18812185
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ERCC4ERCC11083848197175 9722633 Reconstituted Complex
ERCC4ERCC11083798197175 9722633 Reconstituted Complex
FANCAERCC410838412571280 Affinity Capture-Western
FANCAERCC410847212571280 Affinity Capture-Western
SPTA1ERCC411258612571280 Affinity Capture-Western
SPTA1ERCC410838412571280 Affinity Capture-Western
SPTAN1ERCC411258712571280 Affinity Capture-Western
SPTAN1ERCC410838412571280 Affinity Capture-Western
SUMO2ERCC411249719394292 Affinity Capture-MS
SUMO2ERCC410838419394292 Affinity Capture-MS
C20orf94ERCC410838419596235 Affinity Capture-MS
C20orf94ERCC412614719596235 Affinity Capture-MS
SLX1BERCC412247919596235 Affinity Capture-MS
SLX1BERCC410838419596235 Affinity Capture-MS
SLX4ERCC410838419596235 Affinity Capture-MS; Affinity Capture-Western
SLX4ERCC412409719596235 Affinity Capture-MS; Affinity Capture-Western
PLK1ERCC411136219596235 Affinity Capture-Western
PLK1ERCC410838419596235 Affinity Capture-Western
FANCGERCC410838420518486 Two-hybrid
FANCGERCC410848420518486 Two-hybrid
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ERCC4XPF_exon11, rs1799801, rs1799802 Gene overview in AlzGene
No data
No data
Animal Model Top
  • MGI ID: MGI:1354163
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030131-5533'