Gene Symbol:	ESR1 ( DKFZp686N23123,ER,ESR,ESRA,Era,NR3A1 )
Gene Full Name:	estrogen receptor 1
Band:	6q25.1-q25.2
Quick Links	Entrez ID:2099; OMIM: 133430; Uniprot ID:ESR1_HUMAN; ENSEMBL ID: ENSG00000091831; HGNC ID: 3467
Relate to Another Database:	SFARIGene; denovo-db

GO ID	Evidence	Qualifier	GO_term	References
GO:0000790	IDA	-	nuclear chromatin	15831516
GO:0005634	IDA	-	nucleus	9841876
GO:0005654	TAS	-	nucleoplasm	-
GO:0005737	IDA	-	cytoplasm	17505058
GO:0005794	IEA	-	Golgi apparatus	-
GO:0005886	IDA	-	plasma membrane	15569929
GO:0016020	NAS	-	membrane	11960618
GO:0016021	IEA	-	integral component of membrane	-
GO:0035327	IDA	-	transcriptionally active chromatin	17505058
GO:0043234	IMP	-	protein complex	11595744
GO:0097550	IDA	-	transcriptional preinitiation complex	9841876

GO ID	Evidence	Qualifier	GO_term	References
GO:0000978	IDA	-	RNA polymerase II core promoter proximal region sequence-specific DNA binding	12047722
GO:0001046	IDA	-	core promoter sequence-specific DNA binding	15345745
GO:0001077	IDA	-	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	12047722
GO:0001093	IPI	-	TFIIB-class transcription factor binding	9841876
GO:0003682	IDA	-	chromatin binding	17505058
GO:0003700	NAS	-	transcription factor activity, sequence-specific DNA binding	12552091
GO:0003707	TAS	-	steroid hormone receptor activity	10749889
GO:0005496	ISS	-	steroid binding	-
GO:0005515	IPI	-	protein binding	7641693
GO:0008013	IPI	-	beta-catenin binding	15304487
GO:0008134	IPI	-	transcription factor binding	17505058
GO:0008270	IEA	-	zinc ion binding	-
GO:0017025	IPI	-	TBP-class protein binding	11595744
GO:0019899	IPI	-	enzyme binding	12039952
GO:0019901	IPI	-	protein kinase binding	28068668
GO:0030235	NAS	-	nitric-oxide synthase regulator activity	12389206
GO:0030284	IDA	-	estrogen receptor activity	9841876
GO:0030284	NAS	-	estrogen receptor activity	3753802
GO:0030284	TAS	-	estrogen receptor activity	11004670
GO:0030331	IPI	-	estrogen receptor binding	9841876
GO:0034056	IDA	-	estrogen response element binding	9841876
GO:0038052	IDA	-	RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	15831516
GO:0038052	IGI	-	RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding	18722177
GO:0042802	IPI	-	identical protein binding	11265755
GO:0051117	IDA	-	ATPase binding	12058073

GO ID	Evidence	Qualifier	GO_term	References
GO:0000122	IMP	-	negative regulation of transcription from RNA polymerase II promoter	20388878
GO:0001547	IEA	-	antral ovarian follicle growth	-
GO:0002064	IEA	-	epithelial cell development	-
GO:0006338	NAS	-	chromatin remodeling	12351687
GO:0006351	TAS	-	transcription, DNA-templated	2040605
GO:0006355	NAS	-	regulation of transcription, DNA-templated	3753802
GO:0006357	TAS	-	regulation of transcription from RNA polymerase II promoter	-
GO:0006366	IDA	-	transcription from RNA polymerase II promoter	15831516
GO:0006367	TAS	-	transcription initiation from RNA polymerase II promoter	-
GO:0007165	TAS	-	signal transduction	10749889
GO:0007200	ISS	-	phospholipase C-activating G-protein coupled receptor signaling pathway	-
GO:0007204	ISS	-	positive regulation of cytosolic calcium ion concentration	-
GO:0008209	IEA	-	androgen metabolic process	-
GO:0008584	IEA	-	male gonad development	-
GO:0010629	IDA	-	negative regulation of gene expression	21695196
GO:0010863	ISS	-	positive regulation of phospholipase C activity	-
GO:0016579	TAS	-	protein deubiquitination	-
GO:0030518	ISS	-	intracellular steroid hormone receptor signaling pathway	-
GO:0030520	IDA	-	intracellular estrogen receptor signaling pathway	9841876
GO:0030520	NAS	-	intracellular estrogen receptor signaling pathway	3753802
GO:0032355	IDA	-	response to estradiol	15304487
GO:0034121	IEA	-	regulation of toll-like receptor signaling pathway	-
GO:0042981	IEA	-	regulation of apoptotic process	-
GO:0043124	IDA	-	negative regulation of I-kappaB kinase/NF-kappaB signaling	7651415
GO:0043433	IDA	-	negative regulation of sequence-specific DNA binding transcription factor activity	10816575
GO:0043627	IDA	-	response to estrogen	11581164
GO:0045893	IDA	-	positive regulation of transcription, DNA-templated	9841876
GO:0045899	IDA	-	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly	9841876
GO:0045944	IDA	-	positive regulation of transcription from RNA polymerase II promoter	11544182
GO:0048146	IEA	-	positive regulation of fibroblast proliferation	-
GO:0048863	IEA	-	stem cell differentiation	-
GO:0050727	IEA	-	regulation of inflammatory response	-
GO:0051091	IDA	-	positive regulation of sequence-specific DNA binding transcription factor activity	9328340
GO:0060065	IEA	-	uterus development	-
GO:0060068	IEA	-	vagina development	-
GO:0060523	IEA	-	prostate epithelial cord elongation	-
GO:0060527	IEA	-	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis	-
GO:0060687	IEA	-	regulation of branching involved in prostate gland morphogenesis	-
GO:0060745	IEA	-	mammary gland branching involved in pregnancy	-
GO:0060749	IEA	-	mammary gland alveolus development	-
GO:0060750	IEA	-	epithelial cell proliferation involved in mammary gland duct elongation	-
GO:0071168	IMP	-	protein localization to chromatin	20388878
GO:0071391	IEA	-	cellular response to estrogen stimulus	-
GO:0071392	IDA	-	cellular response to estradiol stimulus	15831516
GO:0071392	ISS	-	cellular response to estradiol stimulus	-
GO:1903799	IMP	-	negative regulation of production of miRNAs involved in gene silencing by miRNA	20388878

Gene Symbol	Interactant	Interaction ID	References	Description
ESR1	PARP1	106652	16794079	Affinity Capture-Western
ESR1	PARP1	108403	16794079	Affinity Capture-Western
ESR1	AHR	106699	10620335 12612060	Affinity Capture-Western
ESR1	AHR	108403	10620335 12612060	Affinity Capture-Western
ESR1	BAG1	107049	8524784 15538384	Affinity Capture-Western; Reconstituted Complex
ESR1	BAG1	108403	8524784 15538384	Affinity Capture-Western; Reconstituted Complex
ESR1	CCND1	107067	9039267 16061635	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ESR1	CCND1	108403	9039267 16061635	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ESR1	BRCA1	107140	11244506 11493692 11782371 12400015 16061635 16260778 16860316	Affinity Capture-Western; Co-localization; Reconstituted Complex
ESR1	BRCA1	108403	11244506 11493692 11782371 12400015 16061635 16260778 16860316	Affinity Capture-Western; Co-localization; Reconstituted Complex
ESR1	KLF5	107153	19569049	Affinity Capture-Western; Reconstituted Complex
ESR1	KLF5	108403	19569049	Affinity Capture-Western; Reconstituted Complex
ESR1	CAV1	107305	11563984	Affinity Capture-Western; Reconstituted Complex
ESR1	CAV1	108403	11563984	Affinity Capture-Western; Reconstituted Complex
ESR1	CCNC	107333	11867769	Affinity Capture-Western; Reconstituted Complex
ESR1	CCNC	108403	11867769	Affinity Capture-Western; Reconstituted Complex
ESR1	CCNH	107342	12527756	Affinity Capture-Western
ESR1	CCNH	108403	12527756	Affinity Capture-Western
ESR1	CDC25B	107429	11689696	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ESR1	CDC25B	108403	11689696	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ESR1	CDK7	107457	10949034	Biochemical Activity
ESR1	CDK7	108403	10949034	Biochemical Activity
ESR1	CDK8	107458	11867769	Reconstituted Complex
ESR1	CDK8	108403	11867769	Reconstituted Complex
ESR1	CDKN1A	107460	15743834	Reconstituted Complex
ESR1	CDKN1A	108403	15743834	Reconstituted Complex
ESR1	CEBPA	107479	9817600	Reconstituted Complex
ESR1	CEBPA	108403	9817600	Reconstituted Complex
ESR1	CEBPB	107480	7651415 9817600 16651265 19652226	Affinity Capture-Western; Co-localization; Reconstituted Complex
ESR1	CEBPB	108403	7651415 9817600 16651265 19652226	Affinity Capture-Western; Co-localization; Reconstituted Complex
ESR1	CREBBP	107777	9192902 11113179 11782371 14766010 17400812 18765668	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ESR1	CREBBP	108403	9192902 11113179 11782371 14766010 17400812 18765668	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
ESR1	CTNNB1	107880	15304487	Affinity Capture-Western
ESR1	CTNNB1	108403	15304487	Affinity Capture-Western
ESR1	GADD45A	108014	10872826	Affinity Capture-Western
ESR1	GADD45A	108403	10872826	Affinity Capture-Western
ESR1	DDX5	108021	10409727 11250900	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
ESR1	DDX5	108403	10409727 11250900	Affinity Capture-Western; Phenotypic Enhancement; Reconstituted Complex; Two-hybrid
ESR1	EP300	108347	11782371 11867769 12479814 12574227 12714702 16645043 18765668 19838210	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid
ESR1	EP300	108403	11782371 11867769 12479814 12574227 12714702 16645043 18765668 19838210	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex; Two-hybrid

AutismKB 2.0

Annotation Details for ESR1