AutismKB 2.0

Annotation Details for ESR2


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Basic Information Top
Gene Symbol:ESR2 ( ER-BETA,ESR-BETA,ESRB,ESTRB,Erb,NR3A2 )
Gene Full Name: estrogen receptor 2 (ER beta)
Band: 14q23.2-q23.3
Quick LinksEntrez ID:2100; OMIM: 601663; Uniprot ID:ESR2_HUMAN; ENSEMBL ID: ENSG00000140009; HGNC ID: 3468
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0005576IEA-extracellular region-
GO:0005634IDA-nucleus19126643
GO:0005634TAS-nucleus11181953
GO:0005654TAS-nucleoplasm-
GO:0005739IDA-mitochondrion15024130
GO ID Evidence Qualifier GO_term References
GO:0001046IDA-core promoter sequence-specific DNA binding15345745
GO:0003677TAS-DNA binding9636657
GO:0003700TAS-transcription factor activity, sequence-specific DNA binding8769313
GO:0003707TAS-steroid hormone receptor activity10749889
GO:0003713TAS-transcription coactivator activity8769313
GO:0004879NAS-RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding9671811
GO:0005496ISS-steroid binding-
GO:0005496TAS-steroid binding11181953
GO:0005515IPI-protein binding11279242
GO:0008270IEA-zinc ion binding-
GO:0019899IPI-enzyme binding12039952
GO:0030284TAS-estrogen receptor activity11181953
GO:0034056IDA-estrogen response element binding15345745
GO:0038052IDA-RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding19126643
GO:0048019NAS-receptor antagonist activity9671811
GO ID Evidence Qualifier GO_term References
GO:0000122IDA-negative regulation of transcription from RNA polymerase II promoter15345745
GO:0006355TAS-regulation of transcription, DNA-templated11181953
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0007165TAS-signal transduction8769313
GO:0007267TAS-cell-cell signaling8769313
GO:0030308NAS-negative regulation of cell growth11181953
GO:0030520TAS-intracellular estrogen receptor signaling pathway11181953
GO:0045893IDA-positive regulation of transcription, DNA-templated20074560
GO:0051091IDA-positive regulation of sequence-specific DNA binding transcription factor activity10681512
GO:1900116IEA-extracellular negative regulation of signal transduction-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ESR2SERPINH110840411500849 FRET
ESR2SERPINH110731811500849 FRET
ESR2CCNC10840411867769 Reconstituted Complex
ESR2CCNC10733311867769 Reconstituted Complex
ESR2CDK810840411867769 Reconstituted Complex
ESR2CDK810745811867769 Reconstituted Complex
ESR2CREBBP10840418765668 Affinity Capture-Western
ESR2CREBBP10777718765668 Affinity Capture-Western
ESR2DDX510840411250900 Reconstituted Complex
ESR2DDX510802111250900 Reconstituted Complex
ESR2EP30010834711500849 18765668 Affinity Capture-Western; FRET
ESR2EP30010840411500849 18765668 Affinity Capture-Western; FRET
ESR2ESR11084049473491 10706629 Affinity Capture-Western; Reconstituted Complex
ESR2ESR11084039473491 10706629 Affinity Capture-Western; Reconstituted Complex
NCOA3ESR211384110681591 11389589 11500849 FRET; Reconstituted Complex
NCOA3ESR210840410681591 11389589 11500849 FRET; Reconstituted Complex
MAD2L1ESR210840410706629 Reconstituted Complex; Two-hybrid
MAD2L1ESR211026010706629 Reconstituted Complex; Two-hybrid
MED1ESR210840410770935 11500849 11867769 FRET; Reconstituted Complex; Two-hybrid
MED1ESR211146510770935 11500849 11867769 FRET; Reconstituted Complex; Two-hybrid
NCOA1ESR211420010809226 11500849 14715875 Affinity Capture-Western; FRET; Two-hybrid
NCOA1ESR210840410809226 11500849 14715875 Affinity Capture-Western; FRET; Two-hybrid
DAP3ESR211358710903152 Reconstituted Complex
DAP3ESR210840410903152 Reconstituted Complex
REXO4ESR212137510908561 Reconstituted Complex
REXO4ESR210840410908561 Reconstituted Complex
SRCESR211259211013076 11032808 Affinity Capture-Western; Two-hybrid
SRCESR210840411013076 11032808 Affinity Capture-Western; Two-hybrid
MKNK2ESR210840411013076 Two-hybrid
MKNK2ESR210913011013076 Two-hybrid
PIAS2ESR211452311117529 Reconstituted Complex
PIAS2ESR210840411117529 Reconstituted Complex
NCOA6ESR211669111158331 11773444 Reconstituted Complex; Two-hybrid
NCOA6ESR210840411158331 11773444 Reconstituted Complex; Two-hybrid
DDX17ESR211577611250900 Reconstituted Complex
DDX17ESR210840411250900 Reconstituted Complex
YWHAQESR211616811266503 Reconstituted Complex
YWHAQESR210840411266503 Reconstituted Complex
MAPK1ESR210840411358671 Biochemical Activity
MAPK1ESR211158011358671 Biochemical Activity
NCOA2ESR211576111500849 FRET
NCOA2ESR210840411500849 FRET
JMJD1CESR212867711500849 FRET
JMJD1CESR210840411500849 FRET
NFKBIBESR210840411500849 FRET
NFKBIBESR211086011500849 FRET
NRIP1ESR211384311500849 FRET
NRIP1ESR210840411500849 FRET
TRIM24ESR211433311500849 FRET
TRIM24ESR210840411500849 FRET
TRIP4ESR211473511500849 FRET
TRIP4ESR210840411500849 FRET
ZNHIT3ESR211473611500849 FRET
ZNHIT3ESR210840411500849 FRET
STAT5AESR211265311682624 Reconstituted Complex
STAT5AESR210840411682624 Reconstituted Complex
RBM39ESR211495211704680 Reconstituted Complex; Two-hybrid
RBM39ESR210840411704680 Reconstituted Complex; Two-hybrid
MED6ESR211531911867769 Reconstituted Complex
MED6ESR210840411867769 Reconstituted Complex
MED16ESR210840411867769 Reconstituted Complex
MED16ESR211534211867769 Reconstituted Complex
MED10ESR212397411867769 Reconstituted Complex
MED10ESR210840411867769 Reconstituted Complex
MED14ESR211469911867769 Reconstituted Complex
MED14ESR210840411867769 Reconstituted Complex
MED21ESR211480711867769 Reconstituted Complex
MED21ESR210840411867769 Reconstituted Complex
MED23ESR211482911867769 Reconstituted Complex
MED23ESR210840411867769 Reconstituted Complex
MED17ESR211483011867769 Reconstituted Complex
MED17ESR210840411867769 Reconstituted Complex
MED7ESR211483311867769 Reconstituted Complex
MED7ESR210840411867769 Reconstituted Complex
MED20ESR211486211867769 Reconstituted Complex
MED20ESR210840411867769 Reconstituted Complex
MED24ESR211519611867769 Reconstituted Complex
MED24ESR210840411867769 Reconstituted Complex
MED12ESR211529311867769 Reconstituted Complex
MED12ESR210840411867769 Reconstituted Complex
RBFOX2ESR211708711875103 Reconstituted Complex
RBFOX2ESR210840411875103 Reconstituted Complex
SMARCE1ESR211248912145209 Reconstituted Complex
SMARCE1ESR210840412145209 Reconstituted Complex
DDX54ESR212250312466272 Reconstituted Complex
DDX54ESR210840412466272 Reconstituted Complex
NCOR2ESR211497414715875 Affinity Capture-Western
NCOR2ESR210840414715875 Affinity Capture-Western
DNTTIP2ESR211905215047147 Reconstituted Complex
DNTTIP2ESR210840415047147 Reconstituted Complex
MSH2ESR211057315886699 Affinity Capture-Western; Reconstituted Complex
MSH2ESR210840415886699 Affinity Capture-Western; Reconstituted Complex
UBCESR211316417962381 Affinity Capture-Western
UBCESR210840417962381 Affinity Capture-Western
UBE3AESR211318517962381 Affinity Capture-Western
UBE3AESR210840417962381 Affinity Capture-Western
MYOD1ESR210840418765668 Affinity Capture-Western
MYOD1ESR211073718765668 Affinity Capture-Western
SP1ESR210840418765668 Affinity Capture-Western
SP1ESR211255018765668 Affinity Capture-Western
No data
No data
AlzGene, PDGene and SZGene Top
Gene Symbol Poly Names Gene overview in AlzGene
ESR23'UTR AluI, IVS31842A>G, p[CA] (intron 5), rs1255953, rs1255998, rs1256043, rs1271573, rs4986938 Gene overview in AlzGene
Gene Symbol Poly Names Gene overview in PDGene
ESR2rs1152579, rs1255998, rs1256030, rs1256049, rs4986938, rs928554 Gene overview in PDGene
Gene Symbol Poly Names Gene overview in SZGene
ESR2rs1152588, rs1255998, rs1256030, rs1256063, rs1269056, rs1887994, rs1952585, rs1952586, rs2987983, rs4986938, rs915057, rs944052 Gene overview in SZGene
Animal Model Top
  • MGI ID: MGI:109392
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-030116-1'