AutismKB 2.0

Annotation Details for ESRRA


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Basic Information Top
Gene Symbol:ESRRA ( ERR1,ERRa,ERRalpha,ESRL1,NR3B1 )
Gene Full Name: estrogen-related receptor alpha
Band: 11q13.1
Quick LinksEntrez ID:2101; OMIM: 601998; Uniprot ID:ERR1_HUMAN; ENSEMBL ID: ENSG00000173153; HGNC ID: 3471
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0001650IDA-fibrillar center-
GO:0005634IDA-nucleus-
GO:0005654TAS-nucleoplasm-
GO:0015630IDA-microtubule cytoskeleton-
GO:0045171IDA-intercellular bridge-
GO ID Evidence Qualifier GO_term References
GO:0000978IEA-RNA polymerase II core promoter proximal region sequence-specific DNA binding-
GO:0001077IEA-transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0001078IEA-transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding-
GO:0003677TAS-DNA binding9286700
GO:0003707IEA-steroid hormone receptor activity-
GO:0004879TAS-RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding9286700
GO:0005496IEA-steroid binding-
GO:0005515IPI-protein binding18331830
GO:0008270IEA-zinc ion binding-
GO:0019904IPI-protein domain specific binding11984006
GO:0043565IDA-sequence-specific DNA binding23836911
GO ID Evidence Qualifier GO_term References
GO:0000122IEA-negative regulation of transcription from RNA polymerase II promoter-
GO:0006355IMP-regulation of transcription, DNA-templated23836911
GO:0006367TAS-transcription initiation from RNA polymerase II promoter-
GO:0007005TAS-mitochondrion organization-
GO:0030522IEA-intracellular receptor signaling pathway-
GO:0032355IEA-response to estradiol-
GO:0042127IEA-regulation of cell proliferation-
GO:0043401IEA-steroid hormone mediated signaling pathway-
GO:0045667IEA-regulation of osteoblast differentiation-
GO:0045670IEA-regulation of osteoclast differentiation-
GO:0045944ISS-positive regulation of transcription from RNA polymerase II promoter-
GO:0051216IEA-cartilage development-
GO:1900078IEA-positive regulation of cellular response to insulin stimulus-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
ESRRALYST10755211984006 Two-hybrid
ESRRALYST10840511984006 Two-hybrid
NCOA3ESRRA11384110598588 Reconstituted Complex
NCOA3ESRRA10840510598588 Reconstituted Complex
PPARGC1AESRRA11609715337744 Co-crystal Structure
PPARGC1AESRRA10840515337744 Co-crystal Structure
SP1ESRRA11255016439465 Reconstituted Complex
SP1ESRRA10840516439465 Reconstituted Complex
NRIP1ESRRA11384316439465 Reconstituted Complex
NRIP1ESRRA10840516439465 Reconstituted Complex
ESRRGESRRA10840517157980 17488637 Affinity Capture-Western; Reconstituted Complex
ESRRGESRRA10840717157980 17488637 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:1346831
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-990415-68'