AutismKB 2.0

Annotation Details for MECOM


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Basic Information Top
Gene Symbol:MECOM ( AML1-EVI-1,EVI1,MDS1,MDS1-EVI1,MGC163392,MGC97004,PRDM3 )
Gene Full Name: MDS1 and EVI1 complex locus
Band: 3q26.2
Quick LinksEntrez ID:2122; OMIM: 165215; Uniprot ID:EVI1_HUMAN; ENSEMBL ID: ENSG00000085276,ENSG00000244102; HGNC ID: 3498
Relate to Another Database: SFARIGene; denovo-db
Gene Ontology Top
GO ID Evidence Qualifier GO_term References
GO:0000118IDAcolocalizes_withhistone deacetylase complex11568182
GO:0005634IDA-nucleus15897867
GO:0005829TAS-cytosol-
GO:0016607IDA-nuclear speck11568182
GO ID Evidence Qualifier GO_term References
GO:0003677ISS-DNA binding-
GO:0003700IDA-transcription factor activity, sequence-specific DNA binding19767769
GO:0005515IPI-protein binding10856240
GO:0018024TAS-histone-lysine N-methyltransferase activity-
GO:0046872IEA-metal ion binding-
GO ID Evidence Qualifier GO_term References
GO:0006351IEA-transcription, DNA-templated-
GO:0006915IEA-apoptotic process-
GO:0030154IEA-cell differentiation-
GO:0034968IEA-histone lysine methylation-
GO:0043069IMP-negative regulation of programmed cell death10856240
GO:0045892IDA-negative regulation of transcription, DNA-templated10856240
GO:0045893IDA-positive regulation of transcription, DNA-templated11568182
GO:0046329IMP-negative regulation of JNK cascade10856240
GO:0051726IDA-regulation of cell cycle11568182
GO:0071425ISS-hematopoietic stem cell proliferation-
Protein-Protein Interaction Top
Gene Symbol Interactant Interaction ID References Description
MECOMCREBBP10777711568182 Affinity Capture-Western; Biochemical Activity
MECOMCREBBP10842311568182 Affinity Capture-Western; Biochemical Activity
MECOMCTBP110842311313276 11568182 Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex
MECOMCTBP110786911313276 11568182 Affinity Capture-Western; Phenotypic Enhancement; Phenotypic Suppression; Reconstituted Complex
SMAD3MECOM1102639665135 15849193 Affinity Capture-Western; Reconstituted Complex
SMAD3MECOM1084239665135 15849193 Affinity Capture-Western; Reconstituted Complex
HDAC1MECOM10931511552981 11568182 Affinity Capture-Western; Reconstituted Complex
HDAC1MECOM10842311552981 11568182 Affinity Capture-Western; Reconstituted Complex
HDAC4MECOM10842311568182 Affinity Capture-Western
HDAC4MECOM11510611568182 Affinity Capture-Western
KAT2BMECOM10842311568182 Affinity Capture-Western; Biochemical Activity
KAT2BMECOM11437511568182 Affinity Capture-Western; Biochemical Activity
SMAD1MECOM11026115849193 Reconstituted Complex
SMAD1MECOM10842315849193 Reconstituted Complex
SMAD2MECOM11026215849193 Reconstituted Complex
SMAD2MECOM10842315849193 Reconstituted Complex
SMAD4MECOM10842315849193 Reconstituted Complex
SMAD4MECOM11026415849193 Reconstituted Complex
MBD3MECOM10842318500823 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
MBD3MECOM11978818500823 Affinity Capture-Western; Reconstituted Complex; Two-hybrid
EHMT2MECOM10842318619962 Affinity Capture-Western
EHMT2MECOM11612318619962 Affinity Capture-Western
SUV39H1MECOM10842318619962 18655152 Affinity Capture-Western; Reconstituted Complex
SUV39H1MECOM11270618619962 18655152 Affinity Capture-Western; Reconstituted Complex
No data
No data
AlzGene, PDGene and SZGene Top
Animal Model Top
  • MGI ID: MGI:95457
  • Data Attributes: MGI curated and HomoloGene calculated
SELECT * FROM lijr_20110218_zfin_genotype_phenotype WHERE ZFIN_Gene_ID='ZDB-GENE-050208-123'